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Dietary supplement

Malic Acid Powder 500 mg Ingredients & Drug Interactions

by BulkSupplements.com

Malic Acid Powder 500 mg label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Malic Acid Powder 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Malic Acid Powder 500 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for fibromyalgia symptoms, muscle pain and fatigue, dry mouth (used in some lozenges).Based on those ingredients, 172 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are DL-Malic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Malic Acid Powder 500 mg by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Malic Acid Powder 500 mg by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Malic Acid Powder 500 mg by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: DL-malic acid at 500 mg per serving. Malic acid is an organic compound found naturally in fruits — it's a key part of how cells produce energy and plays a role in muscle metabolism.

There are no inactive ingredients listed for this powder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Malic acid dietary supplement.
  • We looked for evidence on: Dry mouth, Fatigue, Fibromyalgia, Muscle pain, Energy support.
  • The strongest evidence on file: Malic Acid is rated "Possibly Effective" for Dry mouth (Natural Medicines).
  • Also on file: Malic Acid is rated "Insufficient Reliable Evidence To Rate" for Fatigue, Fibromyalgia.

The evidence for malic acid is mixed. It's possibly effective for dry mouth, based on available studies.

For acne, gastroesophageal reflux disease (acid reflux or GERD), fatigue, fibromyalgia, and psoriasis, the evidence is insufficient — we don't yet have reliable data to say whether it works for these uses.

The evidence, ingredient by ingredient Malic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Malic acid taken by mouth appears to be well tolerated overall. However, the safety data we hold focuses mainly on the amounts found in food; supplement doses have not been well studied.

The facts advise caution with supplement-level doses unless your doctor recommends it. When applied to skin, malic acid can cause irritation and peeling, and a few people have experienced allergic skin reactions.

Some individuals taking a supplement combination containing malic acid and magnesium reported diarrhea and nausea, though it's unclear whether the malic acid or the magnesium was responsible — magnesium is known to have a laxative effect at higher doses.

Side effects, ingredient by ingredient Malic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Malic Acid.
  • The most serious interaction on file is rated Moderate.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood pressure medications (antihypertensives) are the main concern — malic acid may increase the blood-pressure-lowering effect, raising your risk of low blood pressure. Check your exact medications before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Malic acid may help with dry mouth. If you take blood pressure medication, check your specific drugs with the tool below before starting — your doctor may need to monitor your blood pressure more closely.

Talk to your pharmacist about whether this product is right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Malic Acid Powder 500 mg, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X003VUGGFF
Net contents 1 KG(s); 35.3 Ounce(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 329891
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Malic Acid Powder 500 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
2000
UPC/BARCODE
X003VUGGFF
IngredientAmount% DV
DL-Malic Acid500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Malic Acid Powder 500 mg per serving

DL-Malic Acid

Brand IP Statement(s)

BulkSupplements.com Clean & pure bulk supplements

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation

Free of: added sugar, soy, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 500 mg (about 1/5 tsp) up to three times daily with meals, or as directed by a physician.

General Statements

Use an accurate milligram scale. New

Storage

Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Malic Acid Powder 500 mg by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Malic Acid Powder 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Malic Acid Powder 500 mg by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Servings per container2000 Amounts shown are per serving.

DL-Malic Acid

Interacts with
172 drugs
500 mg per serving

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain....

DL-Malic Acid monograph & interactions
Interaction report

Malic Acid Powder 500 mg by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Malic Acid Powder 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Moderate

Ingredients driving the most interactions

DL-Malic Acid 172

Individual Drug Interactions

The ingredients in Malic Acid Powder 500 mg interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in Malic Acid Powder 500 mg interact with drugs. Each result below shows which ingredient is responsible. DL-Malic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Malic Acid Powder 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

DL-Malic Acid1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that malic acid isolated from tagetes roots can reduce mean arterial blood pressure.

Likelihood Possible Evidence D
DL-Malic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Malic Acid Powder 500 mg, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Malic Acid Powder 500 mg by BulkSupplements.com: Common Questions

Does Malic Acid Powder 500 mg by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Malic Acid Powder 500 mg has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Malic Acid Powder 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does malic acid really help with dry mouth?
It's possibly effective based on available evidence. That said, the research isn't conclusive, so results may vary. If you try it and don't see improvement after a reasonable time, talk with your pharmacist.
Can I take this while pregnant or breastfeeding?
Malic acid is rated likely safe during pregnancy and lactation. That said, any supplement decision during pregnancy or nursing is a conversation between you and your doctor or midwife — they know your full picture.
What side effects should I watch for?
Taken by mouth, malic acid is generally well tolerated. Diarrhea and nausea have been reported in some people, though in studies it was unclear whether malic acid or another ingredient in the product was responsible. If you experience these, stop and let your pharmacist know.
Is this supplement safe since malic acid is in fruit?
Food amounts are likely fine, but we don't have solid safety data on supplement doses. That's why the caution applies — you're taking much more than you'd get from eating an apple. If you have health concerns, check with your doctor first.
Will this powder interact with my other supplements?
The data we hold covers only malic acid's interactions with medications, not other supplements. Your pharmacist can help you check for interactions between all your supplements and medications together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Malic Acid Powder 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Malic Acid Powder 500 mg label
Go deeper

The Full Monographs Behind Malic Acid Powder 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Malic Acid

Interacts with 172 drugs

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain. The evidence for its health benefits is...

Read the full Malic Acid monograph →
Sources

Sources & How We Checked

Malic Acid Powder 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Malic Acid 7 references
  1. Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol 1995;22:953-8.
  2. Fiume, Z. Final report on the safety assessment of malic acid and sodium malate. Int J Toxicol 2001;20 Suppl 1:47-55. PubMed
  3. Electronic Code of Federal Regulations. Title 21. Part 184 - Direct Food Substances Affirmed as Generally Recognized as Safe. Available at: http://www.ecfr.gov/cgi-bin/text-idx?c=ecfr&sid=786bafc6f6343634fbf79fcdca7061e1&rgn=div5&view=text&node=21:3.0.1.1
  4. Saleem R, Ahmad M, Naz A, et al. Hypotensive and toxicological study of citric acid and other constituents from Tagetes patula roots. Arch Pharm Res 2004;27(10):1037-42.
  5. Chiriac A, Brzezinski P. Topical malic acid in combination with citric acid: an option to treat recalcitrant warts. Dermatol Ther. 2015;28(6):336-8. PubMed
  6. CFR - Code of Federal Regulations Title 21 SUBCHAPTER B. 184.1069 Malic Acid. Food and Drug Administration Department Of Health And Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1069.
  7. Amended Safety Assessment of Malic Acid and Sodium Malate as Used in Cosmetics. Cosmetic Ingredient Review Expert Panel. Updated May 19, 2017. http://www.cir-safety.org/sites/default/files/malic%20acid.pdf. Accessed January 24, 2018.

See these in context on the Malic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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