Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor Ingredients & Drug Interactions

by Aurora Nutrascience

Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor is a dietary supplement by Aurora Nutrascience with 2 active ingredients. Its ingredients are commonly taken for liver health, memory and brain support, ulcerative colitis.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor by Aurora Nutrascience

Ask about any prescription or over-the-counter medication and we check it for interactions with Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor by Aurora Nutrascience — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor by Aurora Nutrascience

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients. Vitamin D3 is the primary nutrient — 9,000 IU per serving — used to support bone health and calcium absorption, especially in conditions like rickets and osteomalacia.

Phosphatidylcholine is a fatty substance from cell membranes that may help with ulcerative colitis and possibly has a role in liver and brain health, though the evidence for some of those uses is still being studied. The liquid also includes inactive ingredients like distilled water, phospholipids, stevia leaf extract for flavor, maltodextrin, cultured dextrose, citric acid, sodium citrate, and xanthan gum as a thickener.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Vitamin D supplementation for bone and immune health.
  • We looked for evidence on: Osteoporosis, Fall prevention, Fractures.
  • The strongest evidence on file: Vitamin D is rated "Likely Effective" for Corticosteroid-induced osteoporosis (Natural Medicines).
  • Also on file: Vitamin D is rated "Possibly Ineffective" for Fractures.
  • Also on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Fall prevention.

Vitamin D3 is proven effective for several bone and mineral conditions — familial hypophosphatemia, osteomalacia (soft bones), renal bone disease, rickets, and hypoparathyroidism. Phosphatidylcholine is possibly effective for ulcerative colitis.

For other conditions phosphatidylcholine is studied for — like Alzheimer's disease, anxiety, fatty liver disease, and alcohol-related liver damage — the evidence in our data is insufficient to rate it one way or the other.

The evidence, ingredient by ingredient Phosphatidylcholine Vitamin D

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D3 is generally well tolerated at recommended doses, though very high doses over time can cause vitamin D toxicity with symptoms like high blood calcium, bone loss, and eye problems. Phosphatidylcholine is generally well tolerated, but high doses (around 30 grams per day) may cause bloating, diarrhea, nausea, vomiting, or altered taste.

It may also increase sweating or itching when taken by mouth. For pregnancy, vitamin D3 is rated likely safe and is often used at recommended amounts, though your doctor should guide your use.

Choline (part of phosphatidylcholine) is needed in pregnancy, but supplement safety beyond food sources isn't well studied — talk with your doctor before starting. For breastfeeding, vitamin D3 is likely safe at recommended doses; data on higher amounts of phosphatidylcholine while breastfeeding is insufficient, so ask your healthcare provider first.

Side effects, ingredient by ingredient Phosphatidylcholine Vitamin D

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 716 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting, double-check with your doctor or pharmacist if you take digoxin, thiazide diuretics, verapamil, diltiazem, atorvastatin, calcipotriene, or medications broken down by liver enzyme CYP3A4. High-dose vitamin D can raise blood calcium and interfere with how some of these drugs work, especially heart medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is useful for supporting bone health with vitamin D3, and the phosphatidylcholine may help if you have ulcerative colitis. If you take heart rhythm medications (digoxin, verapamil, diltiazem), water pills, cholesterol drugs, or psoriasis creams, check with your doctor or pharmacist before adding this — the vitamin D content can interact with those.

Likewise, if you have kidney disease, discuss it first because of aluminum concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor, straight from the product label.

Brand Aurora Nutrascience
Barcode (UPC) 040232521300
Net contents 16 fl. Oz.; 480 mL
Market status On market
Date entered into DSLD Jul 25, 2017
DSLD ID 75780
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor by Aurora Nutrascience, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tbsp
Maximum serving Sizes:
1 Tbsp
Servings per container
32
UPC/BARCODE
040232521300
IngredientAmount% DV
Calories30 Calorie(s)--
Total Fat3 Gram(s)5%
Phosphatidylcholine1.2 Gram(s)--
Vitamin D39000 IU2250%

Other ingredients: distilled Water, Phospholipids, Stevia leaf extract, organic Flavors, Maltodextrin, Cultured Dextrose, Citric Acid, Sodium Citrate, Xanthan Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Dosing cup inside Tear hear

Liposomal delivery technology

Recycle

This helps to protect the Vitamin D-3 nutrients while facilitating a more efficient transition through the digestive system and into the body's bloodstream.

Formula

Mega-Liposomal Vitamin D-3 9000 IU per dose

We use only 100% organic fruit flavoring and stevia to give our product a great taste that everyone can enjoy.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Gluten Free

Non GMO Ingredients

Sugar Free

Formulation

Gluten Free

Sugar Free

Non GMO

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Shake well

Suggested Use As a dietary supplement, take 1 tablespoon (15mL) daily or as directed by your healthcare professional. Shake well before each use. Take on an empty stomach. Drink straight or mix with cold water, juice or yogurt. Do not blend.

Best if consumed within 45 days of opening.

Storage

Refrigerate after opening

Store in a cool dry place away from sunlight and refrigerate after opening.

Brand IP Statement(s)

Why use Mega-Liposomal Vitamin D-3? Our Mega-Liposomal Vitamin D-3 is Vitamin D-3 encapsulated into all-natural lipospheres.

Vida Lifescience

Precautions

Keep out of reach of children.

Consult your healthcare provider if you are pregnant or breastfeeding before consuming this product.

Tamper Evident Customer Protection: Do not use if this tamper evident shrink seal is broken or missing from over the cap, or if the inner cap safety seal is not intact.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor by Aurora Nutrascience label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor by Aurora Nutrascience

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tbsp Dosage formLiquid Servings per container32 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phosphatidylcholine

No known
interactions
1.2 Gram(s) per serving

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, bu...

Phosphatidylcholine monograph & interactions

Vitamin D3

Interacts with
715 drugs
9000 IU per serving

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D3 monograph & interactions

Other (inactive) ingredients: Distilled Water, Phospholipids, Stevia leaf extract, Organic Flavors, Maltodextrin, Cultured Dextrose, Citric Acid, Sodium Citrate, Xanthan Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor by Aurora Nutrascience Drug Interactions

Want to check YOUR meds against Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
715Drugs
80 Moderate 635 Minor

Ingredients driving the most interactions

Vitamin D3 715

Individual Drug Interactions

The ingredients in Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor interact with 715 drugs. Click any drug to see the details.

1 of the 2 ingredients in Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor interact with drugs. Each result below shows which ingredient is responsible. Vitamin D3

Each ingredient & the kinds of drugs it affects

For each ingredient in Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D38 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D3 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor, from the product label.

Aurora Nutrascience

See all Aurora Nutrascience products
Name
Aurora NutraScience
City
Vaughan, ON.
State
CA
Phone Number
1 800-924-6810
Web Address
www.AuroraNutraScience.com
Pharmacist Counseling Corner

Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor by Aurora Nutrascience: Common Questions

Does Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor by Aurora Nutrascience interact with any medications?
Yes. Based on its ingredients, Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor has a known interaction with 715 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does phosphatidylcholine do in this product?
Phosphatidylcholine is a fatty compound from cell membranes that's possibly effective for ulcerative colitis. It may also support liver and brain health, though the evidence for those uses is still being studied.
Is 9,000 IU of vitamin D safe?
Vitamin D is generally well tolerated at recommended doses. This dose is above the standard daily recommendation but below the upper safe limit of 4,000 IU daily that's mentioned in the interaction data. If you have concerns about whether this dose is right for you, talk with your doctor.
Can I take this if I'm pregnant or breastfeeding?
Vitamin D3 is likely safe during pregnancy at recommended amounts and is often used under doctor's guidance. For phosphatidylcholine, choline is needed in pregnancy, but supplement safety beyond food sources isn't well studied — speak with your doctor before taking it. While breastfeeding, vitamin D is likely safe at recommended doses, but check with your healthcare provider about higher amounts.
What side effects might I experience?
Phosphatidylcholine may cause bloating, diarrhea, nausea, altered taste, or increased sweating, especially at higher doses. Vitamin D toxicity is rare at normal doses but can occur with very high amounts over time, causing high blood calcium, bone loss, and eye problems.
Does this interact with my medications?
Yes — if you take heart rhythm drugs like digoxin, verapamil, or diltiazem, water pills, cholesterol medications, or psoriasis creams, this product's vitamin D content can interact. Use the search tool on this page to check your exact medications, then discuss with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor label
Go deeper

The Full Monographs Behind Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylcholine

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...

Read the full Phosphatidylcholine monograph → Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph →
Sources

Sources & How We Checked

Mega-Liposomal Vitamin D-3 9000 IU Organic Fruit Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 41 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylcholine 15 references
  1. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
  3. Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
  4. Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
  5. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
  6. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
  7. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

See these in context on the Phosphatidylcholine monograph →

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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