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Dietary supplement

Melissa Lemon Balm Leaf 1,500 mg Ingredients & Drug Interactions

by Nature's Way

Melissa Lemon Balm Leaf 1,500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Melissa Lemon Balm Leaf 1,500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Melissa Lemon Balm Leaf 1,500 mg is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 264 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lemon Balm. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Melissa Lemon Balm Leaf 1,500 mg by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Melissa Lemon Balm Leaf 1,500 mg by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Melissa Lemon Balm Leaf 1,500 mg by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lemon balm leaf at 1,500 mg per capsule. Lemon balm is a leafy herb traditionally used to support calm and emotional balance.

The capsule itself contains hypromellose, a common inactive ingredient that helps hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Traditional sleep support.
  • We looked for evidence on: Insomnia, Anxiety, Stress, Restlessness, Sleep quality.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia.

The evidence we have suggests lemon balm is possibly effective for cold sores (herpes labialis), stress, and mood support (depression). That means some clinical trials point to a benefit, but the research isn't yet robust enough to call it proven.

If you're considering lemon balm for any of these uses, talk with your pharmacist or doctor about whether the current evidence fits your situation.

The evidence, ingredient by ingredient Lemon Balm

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lemon balm is generally well tolerated for short-term use in healthy adults, though long-term safety and high-dose safety haven't been thoroughly studied. Common side effects like dizziness or sedation don't appear to happen more often with lemon balm than with placebo in trials.

One rare case of heart rhythm abnormality was reported in a product containing lemon balm plus other ingredients, but it's unclear lemon balm alone caused it. The safety data advises against use during pregnancy unless your doctor says otherwise.

If you're breastfeeding, there isn't enough safety information — talk with your doctor before use.

Side effects, ingredient by ingredient Lemon Balm

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lemon Balm.
  • The most serious interaction on file is rated Moderate.
  • For scale: 264 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check whether you take any CNS depressants (sedatives, sleep aids, anxiety medications, or pain drugs that cause drowsiness) or thyroid hormone replacement — these are the two medication categories with documented Moderate interactions with lemon balm.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Lemon balm is a reasonable choice if you're exploring herbal support for stress or cold sores and don't take sedating drugs or thyroid medication. If you do take either, check with your pharmacist first.

It's generally well tolerated short-term, but long-term safety isn't well established, and pregnancy use should be cleared with your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Melissa Lemon Balm Leaf 1,500 mg, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674146507
Net contents 100 Vegan Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 332956
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Melissa Lemon Balm Leaf 1,500 mg by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
33
UPC/BARCODE
033674146507
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Total Sugars1 Gram(s)--
Lemon Balm1.5 Gram(s)--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Traditional sleep support Botanicals are sourced where they grow best Made with the quality you trust

Gluten free. No salt, wheat, corn, soy, dairy, gelatin, or artificial colors, flavors, or preservatives.

Bottled and tested in the USA

Vegan Gelatin free

Vegan Gelatin free

Traditional sleep support Plant powered

Non GMO Project Verified nongmoproject.org

Formula

Melissa Lemon Balm Leaf With 1,500 mg lemon balm leaf per 3-capsule serving

Melissa Lemon Balm Leaf 1,500 mg per 3-capsule serving

General Statements

Explore more products at Naturesway.com

Questions? 1-800-962-8873 / naturesway.com 50% Bottle made from50% post-consumer recycled plastic

Brand IP Statement(s)

Copyright 2024 Nature's Way Brands, LLC

Seals/Symbols

Vegan Gelatin free

Non GMO Project Verified nongmoproject.org

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 3 capsules daily.

Precautions

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Melissa Lemon Balm Leaf 1,500 mg by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Melissa Lemon Balm Leaf 1,500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Melissa Lemon Balm Leaf 1,500 mg by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container33 Amounts shown are per serving.

Lemon Balm

Interacts with
264 drugs
1.5 Gram(s) per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm monograph & interactions

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Melissa Lemon Balm Leaf 1,500 mg by Nature's Way Drug Interactions

Want to check YOUR meds against Melissa Lemon Balm Leaf 1,500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
264Drugs
264 Moderate

Ingredients driving the most interactions

Lemon Balm 264

Individual Drug Interactions

The ingredients in Melissa Lemon Balm Leaf 1,500 mg interact with 264 drugs. Click any drug to see the details.

1 of the 1 ingredient in Melissa Lemon Balm Leaf 1,500 mg interact with drugs. Each result below shows which ingredient is responsible. Lemon Balm

Each ingredient & the kinds of drugs it affects

For each ingredient in Melissa Lemon Balm Leaf 1,500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lemon Balm2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Melissa Lemon Balm Leaf 1,500 mg, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Melissa Lemon Balm Leaf 1,500 mg by Nature's Way: Common Questions

Does Melissa Lemon Balm Leaf 1,500 mg by Nature's Way interact with any medications?
Yes. Based on its ingredients, Melissa Lemon Balm Leaf 1,500 mg has a known interaction with 264 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Melissa Lemon Balm Leaf 1,500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will lemon balm make me drowsy?
Dizziness and sedation have been reported with lemon balm, but clinical trials show these side effects don't occur more often with the herb than with placebo. That said, lemon balm may add to the sedating effects of drugs like sleep aids or anti-anxiety medications, so that's worth checking on with your pharmacist.
Can I take this if I'm pregnant?
There isn't enough reliable safety data, so the data advises against use during pregnancy unless your doctor says it's okay for you. Have that conversation with your doctor or pharmacist before you start.
Is it safe to use while breastfeeding?
Limited safety information exists for breastfeeding, so use caution and talk with your doctor before taking it. We don't have enough data to know one way or the other for certain.
What does lemon balm actually do?
Research suggests lemon balm is possibly effective for cold sores, stress, and mood support. The evidence is promising but not yet definitive, so think of it as a reasonable option to explore alongside other strategies.
Can I take this long-term?
Lemon balm is generally well tolerated for short-term use, but long-term safety and high-dose safety haven't been thoroughly studied. If you're thinking about using it for months, check with your pharmacist about what we do and don't know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Melissa Lemon Balm Leaf 1,500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Melissa Lemon Balm Leaf 1,500 mg label
Go deeper

The Full Monographs Behind Melissa Lemon Balm Leaf 1,500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph →
Sources

Sources & How We Checked

Melissa Lemon Balm Leaf 1,500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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