Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

MenoSense Ingredients & Drug Interactions

by Natural Factors WS WomenSense

MenoSense label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MenoSense against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

MenoSense is a dietary supplement by Natural Factors WS WomenSense with 5 active ingredients. Its ingredients are commonly taken for menopause symptoms, menstrual cramps and irregular periods, premenstrual syndrome (pms).Based on those ingredients, 1,171 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Hesperidin Bioflavonoid extract, Black Cohosh extract, Dong Quai extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against MenoSense by Natural Factors WS WomenSense

Ask about any prescription or over-the-counter medication and we check it for interactions with MenoSense by Natural Factors WS WomenSense — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of MenoSense by Natural Factors WS WomenSense

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

MenoSense contains five active ingredients formulated to address menopausal symptoms. Dong quai extract and black cohosh extract are traditional botanicals used to help ease hot flashes and hormonal shifts.

Chasteberry extract (also called vitex) is included for its potential effects on premenstrual and menstrual health. Gamma oryzanol and hesperidin bioflavonoid extract are added for their antioxidant properties.

The capsule itself is vegetarian, and the product also contains microcrystalline cellulose, magnesium stearate, and silica as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support for menopause symptoms like hot flashes.
  • We looked for evidence on: Menopausal symptoms, Breast cancer-related hot flashes, Night sweats, Vasomotor symptoms.
  • The strongest evidence on file: Black Cohosh is rated "Possibly Effective" for Menopausal symptoms (Natural Medicines).
  • Also on file: Gamma-oryzanol is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms.
  • Also on file: Black Cohosh is rated "Insufficient Reliable Evidence To Rate" for Breast cancer-related hot flashes, Breast cancer.

Evidence for this product's ingredients is mixed. Black cohosh is rated possibly effective for menopausal symptoms like hot flashes.

Chasteberry is rated possibly effective for premenstrual syndrome (PMS) and breast tenderness (mastalgia). Gamma oryzanol is rated possibly effective for high cholesterol (dyslipidemia).

For the other uses mentioned on product labels—such as dong quai for anemia, osteoporosis, or migraines, or black cohosh for anxiety and sexual dysfunction—the evidence in our data is rated insufficient to say whether they work. Hesperidin is rated possibly ineffective for obesity and high cholesterol.

The evidence, ingredient by ingredient Dong Quai Vitex Agnus-castus Black Cohosh Gamma-oryzanol Hesperidin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Dong quai, chasteberry, and black cohosh are generally well tolerated in the short term, though some people report burping, flatulence, diarrhea, fatigue, headache, nausea, and skin irritation. Black cohosh rarely may cause liver concerns, and there is a case report of serotonin syndrome when combined with certain antidepressants.

Hesperidin is generally well tolerated at food levels and in short-term supplement use. Long-term safety data for all ingredients is limited.

During pregnancy, dong quai, chasteberry, and black cohosh are rated possibly unsafe due to possible effects on the uterus and limited safety data—avoid use. Breastfeeding is not recommended with dong quai, chasteberry, or black cohosh because safety is unclear or hormones may be affected.

Gamma oryzanol and hesperidin lack enough safety information in pregnancy and lactation, so they should be avoided as supplements during these times.

Side effects, ingredient by ingredient Dong Quai Vitex Agnus-castus Black Cohosh Gamma-oryzanol Hesperidin

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Black Cohosh, Dong Quai, Vitex Agnus-castus, Hesperidin.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 1,172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take MenoSense, check with your doctor or pharmacist if you're on warfarin or any blood thinner—dong quai carries a Major risk of increased bleeding. Also double-check Moderate interactions: antithrombin or antiplatelet drugs (blood thinners besides warfarin), estrogen or hormone replacement therapy, oral contraceptives, metoclopramide (Reglan), antipsychotic drugs, dopamine agonists, drugs metabolized by CYP2D6 enzymes, hepatotoxic or liver-stressing medications, atorvastatin (Lipitor), cisplatin, serotonergic antidepressants (such as duloxetine and sertraline), CNS depressants (sedatives, sleeping pills), antihypertensive blood pressure drugs, verapamil and diltiazem (heart medications), and celiprolol.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

MenoSense may be worth considering if you're dealing with menopausal hot flashes, especially if black cohosh appeals to you, or if you have premenstrual symptoms and want to try chasteberry. However, you need to be cautious if you take warfarin, other blood thinners, estrogen therapy, antidepressants, antipsychotics, or heart medications—these warrant a careful conversation with your doctor or pharmacist before you start.

Avoid this product during pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MenoSense, straight from the product label.

Brand Natural Factors WS WomenSense
Barcode (UPC) 068958049502
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2017
DSLD ID 76566
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Menopause, Seniors/Mature (>50 Years) - Women ONLY, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MenoSense by Natural Factors WS WomenSense, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
45
UPC/BARCODE
068958049502
IngredientAmount% DV
Dong Quai extract200 mg--
Chasteberry extract160 mg--
Black Cohosh extract160 mg--
Gamma Oryzanol150 mg--
Hesperidin Bioflavonoid extract150 mg--

Other ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

isura Non-GMO - Mass Spec Documentation - Lab tested

Purity & potency guaranteed

Suggested/Recommended/Usage/Directions

Suggested Usage: 2 capsules with breakfast or as directed by a health professional. For nighttime support, add 2 capsules at bedtime.

Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Formula

WomenSense is a line of products dedicated to helping women reach their full health potential.

MenoSense is designed to provide support for symptoms associated with menopause, such as hot flashes and night sweets.

Menopause formula

General Statements

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Reduces hot flashes, night sweats, and other symptoms of menopause.

Product of Canada Recyclable container and label.

Formulation

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish,animal parts, salt, tree nuts, or GMOs.

Suitable for vegetarians/vegans.

Non GMO - Gluten free

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

R8

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MenoSense by Natural Factors WS WomenSense label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MenoSense label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MenoSense by Natural Factors WS WomenSense

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dong Quai extract

Interacts with
163 drugs
200 mg per serving

Dong Quai is a traditional Chinese herb often called "female ginseng" and is mostly used for menstrual and menopausal complaints. High-quality scienti...

Dong Quai extract monograph & interactions

Chasteberry extract

Interacts with
121 drugs
160 mg per serving Form: Aucubin

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS sympto...

Chasteberry extract monograph & interactions

Black Cohosh extract

Interacts with
652 drugs
160 mg per serving Form: Triterpene Glycosides

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It...

Black Cohosh extract monograph & interactions

Gamma Oryzanol

No known
interactions
150 mg per serving Form: Rice extract

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The...

Gamma Oryzanol monograph & interactions

Hesperidin Bioflavonoid extract

Interacts with
702 drugs
150 mg per serving Form: Citrus sinensis, Hesperidin

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and v...

Hesperidin Bioflavonoid extract monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

MenoSense by Natural Factors WS WomenSense Drug Interactions

Want to check YOUR meds against MenoSense?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,171Drugs
2 Major 1,160 Moderate 9 Minor

Ingredients driving the most interactions

Hesperidin Bioflavonoid extract 702
Black Cohosh extract 652
Dong Quai extract 163
Chasteberry extract 121

Individual Drug Interactions

The ingredients in MenoSense interact with 1,171 drugs. Click any drug to see the details.

4 of the 5 ingredients in MenoSense interact with drugs. Each result below shows which ingredient is responsible. Hesperidin Bioflavonoid extract Black Cohosh extract Dong Quai extract Chasteberry extract

Each ingredient & the kinds of drugs it affects

For each ingredient in MenoSense with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Hesperidin Bioflavonoid extract7 drug types · 702 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.

Likelihood Possible Evidence D
Celiprolol (Celicard)

Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.

Likelihood Possible Evidence D
Verapamil (Calan, Others)

Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans

Likelihood Possible Evidence D
Hesperidin Bioflavonoid extract full monograph & interactions

Black Cohosh extract7 drug types · 652 drugs

Atorvastatin (Lipitor)

Taking black cohosh with atorvastatin might increase the risk for elevated liver function tests.
In one case report, a patient taking atorvastatin (Lipitor) developed significantly elevated liver function enzymes after starting black cohosh 100 mg four times daily. Liver enzymes returned to normal when black cohosh was discontinued. It is unclear whether the elevated liver enzymes were due to black cohosh itself or an interaction between atorvastatin and black cohosh.

Likelihood Possible Evidence D
Cisplatin (Platinol-Aq)

Theoretically, black cohosh may reduce the clinical effects of cisplatin.
Animal research suggests that black cohosh might decrease the cytotoxic effect of cisplatin on breast cancer cells.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Some clinical research suggests that black cohosh might modestly inhibit CYP2D6 and increase levels of drugs metabolized by this enzyme. However, contradictory clinical research shows a specific black cohosh product (Remifemin, Enzymatic Therapy) 40 mg twice daily does not significantly inhibit metabolism of a CYP2D6 substrate in healthy study volunteers. Until more is known, use black cohosh cautiously in patients taking drugs metabolized by CYP2D6.

Likelihood Possible Evidence B
Estrogens

Theoretically, black cohosh may alter the effects of estrogen therapy.
Some research suggests that black cohosh has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
There is concern that black cohosh might be linked to cases of liver failure and autoimmune hepatitis.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.
Black cohosh might increase the risk of serotonin syndrome when combined with other serotonergic drugs. Black cohosh acts as an agonist at several serotonin receptor subtypes and might interact with other serotonergic medications. In one case, a 55-year-old female who had been on stable treatment with sertraline 50 mg and duloxetine 60 mg daily developed serotonin syndrome after taking black cohosh extract 40 mg daily for 3 days.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Black cohosh may inhibit one form of OATP, OATP2B1, which could reduce the bioavailability and clinical effects of OATP2B1 substrates.
In vitro research shows that black cohosh modestly inhibits OATP2B1. OATPs are expressed in the small intestine and liver and are responsible for the uptake of drugs and other compounds into the body. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Black Cohosh extract full monograph & interactions

Dong Quai extract3 drug types · 163 drugs

Warfarin (Coumadin)

Dong quai may increase the risk of bleeding when used with warfarin.
Case reports suggest that concomitant use of dong quai with warfarin can increase the anticoagulant effects of warfarin and increase the risk of bleeding. In one case, after 4 weeks of taking dong quai 565 mg once or twice daily, the international normalized ratio (INR) increased to 4.9. The INR normalized 4 weeks after discontinuation of dong quai.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Animal studies suggest that dong quai has antithrombin activity and inhibits platelet aggregation due to its coumarin components. Additionally, some case reports in humans suggest that dong quai can increase the anticoagulant effects of warfarin. However, clinical research in healthy adults shows that taking 1 gram of dong quai root daily for 3 weeks does not significantly inhibit platelet aggregation or cause bleeding. Until more is known, use dong quai with caution in patients taking antiplatelet/anticoagulant drugs.

Likelihood Possible Evidence D
Estrogens

Theoretically, dong quai may reduce the effects of estrogens.
Dong quai has estrogenic effects. Theoretically, concomitant use of large amounts of dong quai might interfere with hormone replacement therapy due to competition for estrogen receptors.

Likelihood Possible Evidence D
Dong Quai extract full monograph & interactions

Chasteberry extract5 drug types · 121 drugs

Antipsychotic Drugs

Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as antipsychotic drugs due to its dopamine agonist effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Vitex agnus-castus might interfere with the efficacy of oral contraceptives due to possible hormone modulating activity.

Likelihood Possible Evidence B
Dopamine Agonists

Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Vitex agnus-castus might potentiate the actions of dopaminergic agonists due to possible dopaminergic effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Vitex agnus-castus has hormone modulating activity that can interfere with the efficacy of hormone replacement therapy.

Likelihood Probable Evidence D
Metoclopramide (Reglan)

Theoretically, dopaminergic effects of vitex agnus-castus could interfere with metoclopramide.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as metoclopramide due to its possible dopaminergic effects.

Likelihood Possible Evidence D
Chasteberry extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MenoSense, from the product label.

Natural Factors WS WomenSense

See all Natural Factors WS WomenSense products
Name
Natural Factors Canada
Pharmacist Counseling Corner

MenoSense by Natural Factors WS WomenSense: Common Questions

Does MenoSense by Natural Factors WS WomenSense interact with any medications?
Yes. Based on its ingredients, MenoSense has a known interaction with 1,171 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MenoSense contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take MenoSense if I'm on warfarin or a blood thinner?
No—dong quai in this product carries a Major interaction with warfarin and a Moderate interaction with other blood thinners, and can increase your bleeding risk significantly. Talk with your doctor or pharmacist before taking it; they may need to adjust your medication or recommend a different approach.
Will MenoSense interfere with my birth control pills?
Possibly. Chasteberry in this product may theoretically interfere with oral contraceptives due to its hormone-modulating effects. Check with your doctor or pharmacist to see whether this product is right for you while on birth control.
Can I take MenoSense while pregnant or breastfeeding?
No. Dong quai, chasteberry, and black cohosh are all rated possibly unsafe in pregnancy and should be avoided because of possible uterine effects and limited safety data. During breastfeeding, safety is unclear for all three, so it's best avoided. Talk with your doctor or pharmacist about safer options.
Is black cohosh in MenoSense safe for my liver?
Black cohosh is generally well tolerated, but there is rare concern about liver damage. If you take other medications that stress the liver, or if you take atorvastatin (Lipitor), check with your doctor or pharmacist first—there's a case report of elevated liver enzymes when the two were combined.
Will MenoSense actually help my hot flashes?
Black cohosh, one of the main ingredients, is rated possibly effective for menopausal hot flashes. Chasteberry is possibly effective for premenstrual symptoms. Results vary from person to person, and you may not notice a difference for several weeks.
What are the most common side effects?
The ingredients are generally well tolerated. Most common side effects include burping, flatulence, diarrhea, fatigue, headache, nausea, and skin irritation. Some people report irregular menstruation. Serious side effects are rare.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MenoSense label
Go deeper

The Full Monographs Behind MenoSense’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Dong Quai

Interacts with 163 drugs

Dong Quai is a traditional Chinese herb often called "female ginseng" and is mostly used for menstrual and menopausal complaints. High-quality scientific evidence that it works for these use...

Read the full Dong Quai monograph → Herb & supplement monograph

Vitex Agnus-castus

Interacts with 121 drugs

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS symptoms. It is generally well tolerated by ma...

Read the full Vitex Agnus-castus monograph → Herb & supplement monograph

Black Cohosh

Interacts with 652 drugs

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It is generally well tolerated for short-t...

Read the full Black Cohosh monograph → Herb & supplement monograph

Gamma-oryzanol

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes fro...

Read the full Gamma-oryzanol monograph → Herb & supplement monograph

Hesperidin

Interacts with 702 drugs

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and varicose veins. Some evidence supports th...

Read the full Hesperidin monograph →
Sources

Sources & How We Checked

MenoSense's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 124 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Dong Quai 19 references
  1. Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981-6. PubMed
  2. Page RL II, Lawrence JD. Potentiation of warfarin by dong quai. Pharmacotherapy 1999;19:870-6. PubMed
  3. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
  4. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  5. Dr. Duke's Phytochemical and Ethnobotanical Databases. Available at: http://www.ars-grin.gov/duke/.
  6. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145-50. PubMed
  7. Shi M, Chang L, He G. [Stimulating action of Carthamus tinctorius L., Angelica sinensis (Oliv.) Diels and Leonurus sibiricus L. on the uterus]. Zhongguo Zhong Yao Za Zhi 1995;20:173-5, 192.
  8. Hoult JR, Paya M. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmacol 1996;27:713-22.. PubMed
  9. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  10. Chang CJ, Chiu JH, Tseng LM, et al. Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells. Eur J Clin Invest 2006;36:588-96. PubMed
  11. Chuang CH, Doyle P, Wang JD, et al. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug Saf 2006;29:537-48. PubMed
  12. Lau CBS, Ho TCY, Chan TWL, Kim SCF. Use of dong quai (Angelica sinensis) to treat peri- and postmenopausal symptoms in women with breast cancer: is it appropriate? Menopause 2005;12:734-40.
  13. Ellis GR, Stephens MR. Untitled (photograph and a brief case report). BMJ 1999;319:650.
  14. Nambiar, S., Schwartz, R. H., and Constantino, A. Hypertension in mother and baby linked to ingestion of Chinese herbal medicine. West J Med 1999;171(3):152.
  15. Lee, S. K., Cho, H. K., Cho, S. H., Kim, S. S., Nahm, D. H., and Park, H. S. Occupational asthma and rhinitis caused by multiple herbal agents in a pharmacist. Ann.Allergy Asthma Immunol. 2001;86(4):469-474. PubMed
  16. Xu, J. and Li, G. [Observation on short-term effects of Angelica injection on chronic obstructive pulmonary disease patients with pulmonary hypertension]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2000;20(3):187-189.
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Vitex Agnus-castus 23 references
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Black Cohosh 68 references
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Hesperidin 14 references
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