Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

Microbiome Protect Ingredients & Drug Interactions

by Douglas Laboratories

Microbiome Protect label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Microbiome Protect against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Microbiome Protect is a dietary supplement by Douglas Laboratories with 4 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are LactoSpore. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Microbiome Protect by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Microbiome Protect by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Microbiome Protect by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 3 active ingredients.

Microbiome Protect contains 3 active ingredients: LactoSpore (a source of Bacillus coagulans, a live probiotic organism), IgY Max, and BioEcolians. These are mixed with natural French Vanilla flavor and Monk Fruit extract as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Bacillus Coagulans's overall clinical evidence instead.

Moderate

Some clinical evidence supports Bacillus Coagulans for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Constipation — rated "Possibly Effective" (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Natural Medicines).

Bacillus coagulans in this product is possibly effective for constipation and irritable bowel syndrome (IBS). For antibiotic-associated diarrhea, athletic performance, cancer prevention, and fatty liver disease (NAFLD), the evidence isn't strong enough yet to say whether it helps.

The data we hold doesn't cover effectiveness claims for IgY Max or BioEcolians.

The evidence, ingredient by ingredient Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus coagulans is generally well tolerated in healthy adults, but the evidence and quality of probiotic products vary widely. There isn't enough reliable safety data to say it's safe for everyone — talk to your doctor before using it.

There's a theoretical concern that live probiotic organisms could cause serious infection in people with weakened immune systems, central lines (medical catheters), or severe illness, though this is rare in people with healthy, intact immune systems. We don't have safety information on file for IgY Max or BioEcolians.

Side effects, ingredient by ingredient Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, space them several hours apart from this product so the antibiotics don't kill the live organisms. Check your exact medications with the tool on this page before you start, especially if you're immunocompromised or have a serious underlying illness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with constipation or IBS if you tolerate probiotics well. If you take antibiotics, have a weakened immune system, a central line, or are severely ill, talk with your doctor or pharmacist before starting — they can tell you whether it's right for you and how to time it with your medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Microbiome Protect, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539978436
Net contents 120 Gram(s); 4.2 Ounce(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232646
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Microbiome Protect by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Gram(s)
Maximum serving Sizes:
8 Gram(s)
Servings per container
15
UPC/BARCODE
310539978436
IngredientAmount% DV
Calories30 Calorie(s), 15 Calorie(s)--
Protein2 Gram(s), 1 Gram(s)4%, 2%
Cholesterol75 mg, 37.5 mg25%, 13%
Total Fat2 Gram(s), 1 Gram(s)3%, 1%
Saturated Fat0.5 Gram(s), 0.25 Gram(s)3%, 1%
LactoSpore0 NP, 0 NP--
IgY Max4.5 Gram(s), 2.25 Gram(s)--
BioEcolians2 Gram(s), 1 Gram(s)--

Other ingredients: natural French Vanilla flavor, Monk Fruit extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1-2 scoops daily blended in 4-8 oz. of water or cold beverage, or as directed by a health professional. For best results, start with 2 scoops daily for the first 4-12 weeks, then continue with 1 scoop daily for maintenance .

Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

Contains: Egg

Brand IP Statement(s)

LactoSpore is a registered trademark of Sabinsa Corporation IgY Max is a registered trademark of IgY Nutrition, LLC BioEcolians is a registered trademark of Solabia

Storage

Store in a cool, dry place.

Formulation

Gluten-free, Dairy-free, Non-GMO

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Packaged by weight, not volume. Settling may occur. Scan to learn about our manufacturing excellence

Servings per container 30 15

FDA Statement of Identity

Dietary Supplement

Formula

IgY Max immunoglobulins, prebiotic and probiotic for intestinal health

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Microbiome Protect by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Microbiome Protect label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Microbiome Protect by Douglas Laboratories

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Gram(s) Dosage formPowder Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

2 Gram(s) per serving

LactoSpore

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

LactoSpore monograph & interactions

IgY Max

4.5 Gram(s) per serving

BioEcolians

2 Gram(s) per serving Form: Alpha-gluco-oligosaccharides

Other (inactive) ingredients: Natural French Vanilla flavor, Monk Fruit extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Microbiome Protect by Douglas Laboratories Drug Interactions

Want to check YOUR meds against Microbiome Protect?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

LactoSpore 182

Individual Drug Interactions

The ingredients in Microbiome Protect interact with 182 drugs. Click any drug to see the details.

1 of the 4 ingredients in Microbiome Protect interact with drugs. Each result below shows which ingredient is responsible. LactoSpore

Each ingredient & the kinds of drugs it affects

For each ingredient in Microbiome Protect with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

LactoSpore1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
LactoSpore full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Microbiome Protect, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Phone Number
1.800.245.4440
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

Microbiome Protect by Douglas Laboratories: Common Questions

Does Microbiome Protect by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, Microbiome Protect has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Microbiome Protect contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this work if I'm taking an antibiotic right now?
The antibiotic might reduce how well the probiotic works by killing some of the live organisms. Ask your doctor or pharmacist how to time them — they may suggest taking them several hours apart.
Is this safe for me if I have a weak immune system?
There's a theoretical concern that live probiotics could cause serious infection in people with weakened immunity, severe illness, or central lines. Talk to your doctor or pharmacist first — they can advise you based on your specific situation.
Can I take this while pregnant or breastfeeding?
We don't have enough safety data on file to say either way for any of these ingredients. Talk to your doctor or pharmacist for personalized advice.
What is Bacillus coagulans, and what does it do?
It's a live probiotic bacterium that may help with constipation and irritable bowel syndrome. The evidence is solid enough to suggest it possibly works for those two conditions, but more research is needed for other uses.
Are there any fillers or other junk in here?
The inactive ingredients are natural French Vanilla flavor and Monk Fruit extract — no unnecessary fillers.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Microbiome Protect is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Microbiome Protect label
Go deeper

The Full Monographs Behind Microbiome Protect’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Microbiome Protect's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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