Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Mood Balance Ingredients & Drug Interactions

by Country Life Gut Connection

Mood Balance label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mood Balance against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mood Balance is a dietary supplement by Country Life Gut Connection with 3 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 415 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bluenesse, Adomix. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mood Balance by Country Life Gut Connection

Ask about any prescription or over-the-counter medication and we check it for interactions with Mood Balance by Country Life Gut Connection — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mood Balance by Country Life Gut Connection

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Mood Balance contains 3 active ingredients. Bluenesse is a branded form of lemon balm extract, traditionally used for stress and mood.

Adomix is the supplement form of SAMe (S-adenosylmethionine), a compound your body makes naturally and that's used for joint health, mood, and liver function. EpiCor is a fermented yeast ingredient.

The capsule also contains inactive ingredients: cellulose, rice bran extract, vegetable glaze, sunflower oil, and silica.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support digestive health and gut microbiome balance.
  • We looked for evidence on: Dyspepsia, Irritable bowel syndrome (IBS), Colic, Gut dysbiosis, Intestinal barrier function, Microbiota composition.
  • The closest evidence on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Irritable bowel syndrome (IBS), Colic.

Bluenesse (lemon balm) is possibly effective for cold sores and stress, and shows possibly effective evidence for depression. Adomix (SAMe) is likely effective for osteoarthritis and possibly effective for depression and cholestasis (a liver condition).

For Alzheimer's disease and ADHD, the evidence for SAMe isn't established enough to rate. We don't have effectiveness data on file for EpiCor.

The evidence, ingredient by ingredient Lemon Balm Same

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bluenesse is generally well tolerated for short-term use in healthy adults, though long-term safety isn't well studied. Dizziness and sedation are reported in the medical literature, but they don't occur more often with lemon balm than placebo.

Adomix (SAMe) is often well tolerated short-term, but can cause stomach upset—nausea, diarrhea, constipation, and headache are the most common side effects, especially at higher doses. SAMe may trigger mania in people with bipolar disorder.

One rare case of heart rhythm changes was reported with a product containing lemon balm and other ingredients, but the cause wasn't clear. During pregnancy, the safety data on lemon balm advises against use unless your doctor says otherwise.

For breastfeeding, talk to your doctor first—there's limited safety information. We don't have pregnancy or breastfeeding safety data on file for SAMe or EpiCor.

Side effects, ingredient by ingredient Lemon Balm Same

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lemon Balm, Same.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 415 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before you take this: serotonergic drugs (antidepressants, anti-anxiety medications, and some pain relievers) — risk of serotonin syndrome; CNS depressants (sedatives, sleeping pills); thyroid hormone replacement therapy; and levodopa (Parkinson's disease). No interactions are documented in our data for EpiCor.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is worth considering if you're looking for natural support for mood and stress and don't take serotonergic antidepressants, sleeping pills, anxiety medications, thyroid hormone, or levodopa. If you take any prescription medication, run it through the checker on this page first.

Talk to your pharmacist before starting, especially if you have bipolar disorder or are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mood Balance, straight from the product label.

Brand Country Life Gut Connection
Barcode (UPC) 015794030171
Net contents 60 Vegan Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 333237
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mood Balance by Country Life Gut Connection, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
015794030171
IngredientAmount% DV
EpiCor630 mg--
Bluenesse300 mg--
Adomix100 mg--

Other ingredients: Cellulose, Rice Bran Extract, Vegetable Glaze, Sunflower Oil, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Good health starts in your gut.

This product has been manufactured at a GMP Registered Facility.

Why? Supports healthy shift in gut microbiotca composition Helps maintain the gut lining Maintains gut barrier function Stimulates healthy bacteria in the gut Supports overall gut microbiome Based on results from a study using a dynamic model representing GI digestion.

Money back guarantee You'll love it. If not completely satisfied, request a refund within 60 days of purchase. See details at www.GutConnectionRebate.com or call 877-322-8355.

It's all connected. Good digestion starts in the gut, but so does a good mood, a healthy immune system, energy levels and sleep.

Money back guarantee

Probiotic free

Improves gut microbiome health Maintains a positive mood Promotes calmness Our pledge of integrity Authenticity Cleanliness Freshness Consistency Accuracy

Yes Certified gluten-free by GFCO.org No GMOs No wheat, soy or milk No salt, sugar or preservatives No artificial colors, flavors or sweeteners No magnesium stearate

Yes Certified vegan by the AVA

Yes manufacturing supports wind power

Formula

Gut connection Mood Balance by Country Life is specially and scientifically formulated to help improve your digestive health. Our clinically tested ingredients together are "Balanced Inside" for your digestive health. EpiCor helps maintain good digestive and immune health. EpiCor is a registered trademark of Embria Health Sciences, LLC SAM-e helps maintain neurotransmitters that support mood. Bluenesse helps support and maintain a positive mood. Bluenesse is a trademark of Vital Solutions GmbH, Germany.

Gut Connection contains 630 mg of clinically researched EpiCor. Epicor

EpiCor is a whole food fermentate prebiotic that balances and strengthens your gut by boosting its levels of good bacteria to promote health every day. Made using a fermented whole food yeast (Saccharomyces cervisiae), it captures a complex array of beneficial nutrients through the process of fermentation. Each daily serving will improve your gut and your health-it's all connected! A healthy gut has more than 10 trillion bacteria! Gut Connection is different because it does not provide probiotics, so you can take it alone or with your favorite probiotic. This allows your body to create its own healthy bacteria.

Gut Connection by Country Life is scientifically formulated range of supplements that connects the gut to individual health issues that matter.

Clinically studied ingredients

Yes Kosher-Parve

General Statements

For more information on EpiCor and on Country Life's Gut Connection Go to CountryLifeVitamins.com Digestivebalance Sleepbalance Weightbalance Cognitivebalance

Stressbalance Moodbalance Immunebalance

Yes recyclable packaging

Seals/Symbols

Certified B Corporation Certified Gluten Free GFCO.org (Gluten-Free Certification Organization) KOF-K (Kosher) Parve

Brand IP Statement(s)

Country Life Established 1971

EpiCor is a registered trademark of Embria Health Sciences, LLC Adomix is a registered trademark of Gnosis S.p.A. Bluenesse is a trademark of Vital Solutions GmbH, Germany. Copyright 2022 Country Life

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults take two (2) capsules daily with food.

Precautions

As a reminder, discuss the supplements and medications that you take with your health care providers.

Caution: If you are pregnant, nursing, or taking medication, have a medical condition or planning surgery, consult a doctor before using this product.

Stop using and consult a doctor if any adverse reactions occur. Do not accept if seal is broken.

Keep out of the reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a dry place between 59 degrees - 86 degrees F.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mood Balance by Country Life Gut Connection label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mood Balance label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mood Balance by Country Life Gut Connection

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

EpiCor

630 mg per serving Form: Yeast Fermentate, Dried

Bluenesse

Interacts with
264 drugs
300 mg per serving Form: Lemon Balm Leaf Extract

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Bluenesse monograph & interactions

Adomix

Interacts with
189 drugs
100 mg per serving Form: SAM-e

SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it ma...

Adomix monograph & interactions

Other (inactive) ingredients: Cellulose, Rice Bran Extract, Vegetable Glaze, Sunflower Oil, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mood Balance by Country Life Gut Connection Drug Interactions

Want to check YOUR meds against Mood Balance?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
415Drugs
415 Moderate

Ingredients driving the most interactions

Bluenesse 264
Adomix 189

Individual Drug Interactions

The ingredients in Mood Balance interact with 415 drugs. Click any drug to see the details.

2 of the 3 ingredients in Mood Balance interact with drugs. Each result below shows which ingredient is responsible. Bluenesse Adomix

Each ingredient & the kinds of drugs it affects

For each ingredient in Mood Balance with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bluenesse2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Bluenesse full monograph & interactions

Adomix2 drug types · 189 drugs

Levodopa

SAMe might reduce the effectiveness of levodopa.
SAMe methylates levodopa, which might reduce its effectiveness for treating Parkinson disease.

Likelihood Possible Evidence D
Serotonergic Drugs

Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
SAMe has serotonergic effects. Theoretically, combining serotonergic drugs with SAMe might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. In one case report, SAMe 100 mg intramuscularly was given daily with clomipramine (Anafranil) 25 mg per day. When the clomipramine dose was increased to 75 mg per day the patient experienced serotonin syndrome about 48-72 hours later, requiring hospitalization.

Likelihood Possible Evidence D
Adomix full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mood Balance, from the product label.

Country Life Gut Connection

See all Country Life Gut Connection products
Name
Country Life, LLC
Street Address
180 Vanderbilt Motor Parkway
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
877-322-8355
Web Address
CountryLifeVitamins.com
Pharmacist Counseling Corner

Mood Balance by Country Life Gut Connection: Common Questions

Does Mood Balance by Country Life Gut Connection interact with any medications?
Yes. Based on its ingredients, Mood Balance has a known interaction with 415 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mood Balance contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
Lemon balm can cause dizziness and sedation, especially if you're also taking sleep aids or sedatives. However, the medical literature shows these effects don't happen more often with lemon balm than with placebo. If you notice drowsiness, take it at bedtime or talk to your pharmacist.
Is SAMe the same as the amino acid that sounds similar?
No—SAMe (S-adenosylmethionine) is a compound your body naturally makes, not an amino acid. It's used for joint health, mood, and liver function. It's different from other supplements that support mood.
Can I take this if I'm on an antidepressant?
Not without checking first. SAMe can interact with antidepressants and raise the risk of serotonin syndrome. Use the medication checker on this page with your exact drug name, or talk to your pharmacist before starting.
What's EpiCor?
EpiCor is a fermented yeast ingredient in this product. We don't have interaction or effectiveness data on file for it, so we can't tell you how it works or whether it affects your medications.
Can I take this while pregnant?
Lemon balm is best avoided during pregnancy unless your doctor advises otherwise—there isn't enough safety data. We also don't have pregnancy safety information on file for SAMe or EpiCor. Talk to your doctor before starting.
What's the most common side effect?
SAMe most often causes stomach upset—nausea, diarrhea, constipation, or headache—and these happen more with higher doses. Lemon balm is generally well tolerated, though dizziness is reported in some cases. Start low and watch how you feel.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mood Balance is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mood Balance label
Go deeper

The Full Monographs Behind Mood Balance’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Same

Interacts with 189 drugs

SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it may help with these conditions, but the qu...

Read the full Same monograph →
Sources

Sources & How We Checked

Mood Balance's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 43 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Same 31 references
  1. Perna AF, Castaldo P, Ingrosso D, et al. Homocysteine, a new cardiovascular risk factor, is also a powerful uremic toxin. J Nephrol 1999;12:230-40.
  2. Mato JM, Camara J, Fernandez de Paz J, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30:1081-9. PubMed
  3. Iruela LM, Minguez L, Merino J, Monedero G. Toxic interaction of S-adenosylmethionine and clomipramine. Am J Psychiatry 1993;150:522. PubMed
  4. Bradley JD, Flusser D, Katz BP, et al. A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis. J Rheumatol 1994;21:905-11.
  5. Berlanga C, Ortega-Soto HA, Ontiveros M, Senties H. Efficacy of S-adenosyl-L-methionine in speeding the onset of action of imipramine. Psychiatry Res 1992;44:257-62. PubMed
  6. Kagan BL, Sultzer DL, Rosenlicht N, Gerner RH. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry 1990;147:591-5. PubMed
  7. Rosenbaum JF, Fava M, Falk WE, et al. The antidepressant potential of oral S-adenosyl-l-methionine. Acta Psychiatr Scand 1990;81:432-6. PubMed
  8. Domljan Z, Vrhovac B, Durrigl T, Pucar I. A double-blind trial of ademetionine vs naproxen in activated gonarthrosis. Int J Clin Pharmacol Ther Toxicol 1989;27:329-33.
  9. Konig B. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med 1987;83:89-94. PubMed
  10. Lipinski JF, Cohen BM, Frankenburg F, et al. Open trial of S-adenosylmethionine for treatment of depression. Am J Psychiatry 1984;141:448-50.
  11. Almasio P, Bortolini M, Pagliaro L, Coltorti M. Role of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis. Drugs 1990;40:111-23. PubMed
  12. Friedel HA, Goa KL, Benfield P. S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 1989;38:389-416. PubMed
  13. Bottiglieri T, Hyland K, Reynolds EH. The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Drugs 1994;48:137-52. PubMed
  14. Frezza M, Centini G, Cammareri G, et al. S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. Hepatogastroenterology 1990;37:122-5.
  15. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  16. Charlton CG, Crowell B Jr. Parkinson's disease-like effects of S-adenosyl-L-methionine: effects of L-dopa. Pharmacol Biochem Behav 1992;43:423-31..
  17. Goren JL, Stoll AL, Damico KE, et al. Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans. Pharmacotherapy 2004;24:1501-7. PubMed
  18. Arnold O, Saletu B, Anderer P, et al. Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine (SAMe) in elderly subjects, utilizing EEG mapping and psychometry. Eur Neuropsychopharmacol 2005; PubMed
  19. Nelson JC. S-adenosyl methionine (SAMe) augmentation in major depressive disorder. (Editorial). Am J Psychiatry 2010;167:889-91.
  20. Kim J, Lee EY, Koh EM, et al. Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients. Clin Ther 2009; PubMed
  21. Manzillo G, Piccinino F, Surrenti C, et al. Multicentre double-blind placebo-controlled study of intravenous and oral S-adenosyl-L-methionine (SAMe) in cholestatic patients with liver disease. Drug Invest 1992;4 (Suppl 4):90-100. DOI
  22. Carrieri PB, Indaco A, Gentile S, et al. S-adenosylmethionine treatment of depressioin in patients with Parkinson's disease: a double-blind, crossover study versus placebo. Curr Ther Res 1990;48(1):154-60.
  23. Pancheri P, Scapicchio P, Delle Chiaie R. A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder. Int J Neuro PubMed
  24. Medici V., Virata M. C., Peerson J. M., Stabler S. P., French S. W., Gregory J. F. III, Albanese A., Bowlus C. L., Devaraj S., Panacek E. A., Richards J. R., Halsted C. H. S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, ra
  25. Chitiva, H., Audivert, F., and Alvarez, C. Suicide attempt by self-burning associated with ingestion of S-adenosylmethionine: a review of the literature and case report. J.Nerv.Ment.Dis. 2012;200(1):99-101. PubMed
  26. Carney, M. W., Edeh, J., Bottiglieri, T., Reynolds, E. M., and Toone, B. K. Affective illness and S-adenosyl methionine: a preliminary report. Clin Neuropharmacol. 1986;9(4):379-385. PubMed
  27. Miccoli, L., Porro, V., and Bertolino, A. Comparison between the antidepressant activity and of S- adenosylmethionine (SAMe) and that of some tricyclic drugs. Acta Neurol (Napoli) 1978;33 (3):243-255.
  28. Bacci, Ballerini F., Lopez, Anguera A., Alcaraz, P., and Hernandez, Reyes N. [SAMe in the management of postconcussional syndrome]. Medicina Clinica (Barc.) 1983;80(4):161-164.
  29. Muscettola G, Galzenati M, Balbi A. SAMe versus placebo: a double blind comparison in major depressive disorders. Advances in Biochemical Psychopharmacology 1982;32:151-6.
  30. Capretto C, Cremona C, and Canaparo L. A double-blind controlled study of S-adenosylmethionine (SAMe) v. ibuprofen in gonarthrosis, coxarthrosis and spondylarthrosis. Clin Trials J 1985;22(1):15-24.
  31. Ancarani E, Biondi B, Bolletta A, et al. Major depression complicating hemodialysis in patients with chronic renal failure: a multicenter, double-blind, controlled clinical trial of S-adenosyl-L-methionine versus placebo. Curr Ther Res 1993;54(6):680-6. DOI

See these in context on the Same monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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