Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Stress Balance Ingredients & Drug Interactions

by Country Life Gut Connection

Stress Balance label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Stress Balance against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Stress Balance is a dietary supplement by Country Life Gut Connection with 4 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 1,377 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril, Suntheanine, L-Tyrosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Stress Balance by Country Life Gut Connection

Ask about any prescription or over-the-counter medication and we check it for interactions with Stress Balance by Country Life Gut Connection — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Stress Balance by Country Life Gut Connection

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Sensoril” is listed as a grouped ingredient — the label gives one combined amount (125 mg) without saying how much of each component you get.

Stress Balance contains 4 active ingredients. Suntheanine (the branded form of theanine) is an amino acid that may support relaxation and focus.

L-Tyrosine is another amino acid involved in brain chemistry and stress response. Withanolide Glycosides (the active compounds from ashwagandha, which appear to be part of the Sensoril blend) and EpiCor (a fermented yeast ingredient) round out the formula.

The capsules also contain inactive ingredients — cellulose, rice bran extract, vegetable glaze, sunflower oil, and silica — which serve as fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: help improve digestive health and deal with stress.
  • We looked for evidence on: Stress, Anxiety, Generalized anxiety disorder (GAD), Fatigue, Insomnia, Depression — and 4 related terms.
  • The strongest evidence on file: Tyrosine is rated "Possibly Effective" for Cognitive function (Natural Medicines).
  • Also on file: Theanine is rated "Possibly Effective" for Cognitive function.
  • Also on file: Tyrosine is rated "Insufficient Reliable Evidence To Rate" for Depression, Fatigue, Stress.

Theanine is possibly effective for cognitive function, though the evidence for age-related memory loss, Alzheimer's disease, and anxiety disorders like GAD and OCD is not yet established in the data we hold. L-Tyrosine is possibly effective for cognitive function and memory, and is effective for the rare genetic condition phenylketonuria (PKU).

However, it appears possibly ineffective for athletic performance. The evidence for the other ingredients and conditions listed isn't established in our data.

The evidence, ingredient by ingredient Theanine Ashwagandha Tyrosine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Theanine and L-Tyrosine are generally well tolerated in healthy adults, though long-term safety for Theanine hasn't been well studied. Common side effects of Theanine include headaches, drowsiness, and increased dream activity.

L-Tyrosine may cause fatigue, headache, heartburn, and nausea, especially at higher doses. Neither ingredient has enough safety data during pregnancy, so it's best to avoid them if you're pregnant.

Theanine should also be avoided while breastfeeding due to insufficient data. For L-Tyrosine, caution is advised while breastfeeding.

If you're planning pregnancy or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Theanine Ashwagandha Tyrosine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Tyrosine, Theanine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 586 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on levodopa (a Parkinson's drug) or thyroid hormone medication — both have moderate interactions with L-Tyrosine that need careful timing or dosing. If you take blood pressure medications, Theanine may strengthen their effect, which your doctor should know about.

Similarly, if you're on sedating medications or supplements, let your pharmacist know about the minor interaction with Theanine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Stress Balance may help with focus and cognitive function if Theanine and L-Tyrosine are right for your situation, but it's not for everyone. If you take levodopa, antihypertensive drugs, thyroid medication, or sedating medications, check with your pharmacist first.

Pregnant or breastfeeding individuals should avoid it. Talk to your pharmacist about whether this product fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Stress Balance, straight from the product label.

Brand Country Life Gut Connection
Barcode (UPC) 015794030119
Net contents 60 Vegan Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 333235
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Stress Balance by Country Life Gut Connection, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
015794030119
IngredientAmount% DV
Withanolide Glycosides10 mg--
Suntheanine100 mg--
Sensoril125 mg--
L-Tyrosine250 mg--
EpiCor630 mg--

Other ingredients: Cellulose, Rice Bran Extract, Vegetable Glaze, Sunflower Oil, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Good health starts in your gut. Gut Connection Stress Balance by Country Life is specially and scientifically formulated to help improve your digestive health. Our clinically tested ingredients together are "Balanced Inside" for your digestive health. EpiCor helps maintain good digestive and immune health. Sensoril shown to equip the body to deal with stress, irritability and fatigue. L-Theanine promotes relaxation. L-Tyrosine supports the product of brain neurotransmitters dopamine and norepinephrine. This product has been manufactured at a GMP Registered facility.

Gut Connection contains 630 mg of clinically researched EpiCor. Why? Supports healthy shift in gut microbiota composition Helps maintain the gut lining Supports overall gut microbiome Maintains gut barrier function Stimulates healthy bacteria in the gut EpiCor is a whole food fermentate prebiotic that balances and strengthens your gut by boosting its levels of good bacteria to promote health every day. Each daily serving will improve your gut and your health- it's all connected! A healthy gut has more than 10 trillion bacteria! Gut Connection is different because it does not provide probiotics, so you can take it alone or with your favorite probiotic. This allows your body to create its own healthy bacteria. Based on results from a study using a dynamic model representing GI digestion.

Money back guarantee You'll love it. If not completely satisfied, request a refund within 60 days of purchase. See details at www.GutConnectionRebate.com or call 877-322-8355.

Certified Gluten Free GFCO.org

It's all connected. Good digestion starts in the gut, but so does a good mood, a healthy immune system, energy levels and sleep. Gut Connection by Country Life is a scientifically formulated range of supplements that connects the gut to individual health issues that matter.

Money back guarantee

Probiotic free

Improves gut microbiome health Promotes mental calmness Diminishes occasional tension Clinically studied ingredients

Yes Certified Gluten-free by GFCO.org NO GMOs No Wheat, soy or milk No Salt, sugar or preservatives No Artificial colors, flavors, or sweeteners No Magnesium Stearate

Certified Vegan by the AVA

Yes Manufacturing supports wind power

Formula

EpiCor helps maintain good digestive and immune health. Sensoril shown to equip the body to deal with stress, irritability and fatigue. L-Theanine promotes relaxation. L-Tyrosine supports the product of brain neurotransmitters dopamine and norepinephrine.

Gut Connection contains 630 mg of clinically researched EpiCor.

EpiCor

Made using a fermented whole food yeast (Saccharomyces cerevisiae), it captures a complex array of beneficial nutrients through the process of fermentation.

K Parve (Kosher)

Yes Kosher-Parve

General Statements

For more information on EpiCor and on Country Life's Gut Connection Go to CountryLifeVitamins.com

digestivebalance sleepbalance weightbalance cognitivebalance stressbalance moodbalance immunebalance

Our Pledge of Integrity Authenticity Cleanliness Freshness Consistency Accuracy

Yes recyclable packaging

Seals/Symbols

Certified B Corporation Certified Gluten Free GFCO.org K Parve (Kosher)

Brand IP Statement(s)

Country Life Established 1971

Suntheanine is a registered trademark of Taiyo International, Inc. Sensoril is a trademark of Natreon, Inc. EpiCor is a registered trademark of Embria Health Sciences, LLC. Copyright 2022 Country Life

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults take two (2) capsules daily with food.

Precautions

As a reminder, discuss the supplements and medications that you take with your health care providers.

Caution: Not to be used during pregnancy. If you are nursing, taking medication, have a medical condition or planning surgery, consult a doctor before using this product.

May potentiate the effects of barbiturates. Stop using and consult a doctor if any adverse reactions occur. Do not accept if seal is broken.

Keep out of the reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a dry place between 59 degrees - 86 degrees F.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Stress Balance by Country Life Gut Connection label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Stress Balance label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Stress Balance by Country Life Gut Connection

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Suntheanine

Interacts with
565 drugs
100 mg per serving Form: L-Theanine

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

Suntheanine monograph & interactions

Sensoril

Interacts with
1,372 drugs
125 mg per serving Form: Ashwagandha Leaf, Root Extract

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Sensoril monograph & interactions
  • › Withanolide Glycosides

L-Tyrosine

Interacts with
21 drugs
250 mg per serving

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...

L-Tyrosine monograph & interactions

EpiCor

630 mg per serving Form: Yeast Fermentate, Dried

Other (inactive) ingredients: Cellulose, Rice Bran Extract, Vegetable Glaze, Sunflower Oil, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Stress Balance by Country Life Gut Connection Drug Interactions

Want to check YOUR meds against Stress Balance?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,377Drugs
921 Moderate 456 Minor

Ingredients driving the most interactions

Sensoril 1,372
Suntheanine 565
L-Tyrosine 21

Individual Drug Interactions

The ingredients in Stress Balance interact with 1,377 drugs. Click any drug to see the details.

3 of the 4 ingredients in Stress Balance interact with drugs. Each result below shows which ingredient is responsible. Sensoril Suntheanine L-Tyrosine

Each ingredient & the kinds of drugs it affects

For each ingredient in Stress Balance with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Sensoril full monograph & interactions

Suntheanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
Suntheanine full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Stress Balance, from the product label.

Country Life Gut Connection

See all Country Life Gut Connection products
Name
Country Life, LLC
Street Address
180 Vanderbilt Motor Parkway
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
877-322-8355
Web Address
CountryLifeVitamins.com
Pharmacist Counseling Corner

Stress Balance by Country Life Gut Connection: Common Questions

Does Stress Balance by Country Life Gut Connection interact with any medications?
Yes. Based on its ingredients, Stress Balance has a known interaction with 1,377 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Stress Balance contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No — there isn't enough safety data for either Theanine or L-Tyrosine during pregnancy, so it's best to avoid them. Talk with your doctor or pharmacist about what's safe for you right now.
Can I take this while breastfeeding?
Theanine should be avoided while breastfeeding due to lack of safety data. L-Tyrosine carries a caution during breastfeeding. Speak with your pharmacist or doctor for personalized advice.
What are the most common side effects?
Theanine may cause headaches, drowsiness, or increased dream activity. L-Tyrosine may cause fatigue, headache, heartburn, and nausea. Most people tolerate it well, but if you notice any of these, lower the dose or stop and talk to your pharmacist.
Does this actually work for stress and focus?
Theanine is possibly effective for cognitive function based on current evidence. L-Tyrosine is possibly effective for cognitive function and memory. The evidence isn't rock-solid for stress itself, so individual results vary.
What is L-Tyrosine used for in this product?
L-Tyrosine is an amino acid your body uses to make dopamine and norepinephrine — neurotransmitters involved in mood, focus, and stress response. It's included to support mental clarity and resilience.
What about the ashwagandha in the Sensoril blend — does it interact with medications?
We hold no interaction data on file for Withanolide Glycosides or the Sensoril blend itself. If you're on other medications, check the tool on this page or ask your pharmacist to be sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Stress Balance is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Stress Balance label
Go deeper

The Full Monographs Behind Stress Balance’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph →
Sources

Sources & How We Checked

Stress Balance's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 42 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Ashwagandha 32 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
  3. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
  4. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
  5. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
  6. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
  7. Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
  8. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
  9. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
  10. Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
  11. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
  12. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
  13. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
  14. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
  15. Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059.
  16. Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. PubMed
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See these in context on the Ashwagandha monograph →

Tyrosine 4 references
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See these in context on the Tyrosine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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