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Dietary supplement

Mulberry Leaf Extract 500 mg Ingredients & Drug Interactions

by Best Naturals

Mulberry Leaf Extract 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mulberry Leaf Extract 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mulberry Leaf Extract 500 mg is a dietary supplement by Best Naturals with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, weight management.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mulberry Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mulberry Leaf Extract 500 mg by Best Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Mulberry Leaf Extract 500 mg by Best Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mulberry Leaf Extract 500 mg by Best Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: mulberry leaf extract at 500 mg per capsule. Mulberry leaf has been studied for its effects on blood sugar and other metabolic markers.

The capsule itself is filled with inactive ingredients — cellulose, silica, and vegetable stearate — which help bind and deliver the extract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see White Mulberry's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports healthy blood sugar and cardiovascular health.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Hyperlipidemia, Hypertension, metabolic syndrome, dyslipidemia.
  • The closest evidence on file: White Mulberry is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: White Mulberry is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertension, Impaired glucose tolerance (prediabetes).

The evidence for mulberry leaf extract isn't established in our data. We hold insufficient reliable evidence to rate its use for androgenic alopecia (hair loss), bone health (osteoporosis), cold symptoms, blood sugar control (diabetes), or cholesterol levels (hyperlipidemia).

If you're considering this supplement for any of these reasons, talk with your doctor about what the current research actually shows and whether it makes sense for your situation.

The evidence, ingredient by ingredient White Mulberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Mulberry leaf extract is generally well tolerated when taken by mouth. The most common side effects — bloating, gas, loose stools, and constipation — are mild and digestive; in one clinical study, they affected roughly half the participants at the start but tended to improve over the 12-week period, suggesting your body may adjust over time.

During pregnancy and breastfeeding, there isn't enough safety data on concentrated supplements to know either way. The safety notes advise against medicinal amounts in both cases.

Talk with your doctor or pharmacist about whether this is right for you if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient White Mulberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — White Mulberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 87 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take diabetes medications (there's a moderate risk of low blood sugar) or any OCT2 substrate drugs, particularly metformin, which may accumulate in your body if taken with mulberry leaf. Your provider can help you weigh the risks and plan any monitoring you might need.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Mulberry leaf extract is generally easy on the stomach, though a few weeks of mild bloating or loose stools is common at first. The real decision point is whether you take diabetes medication or drugs cleared through your kidneys — if you do, check those exact medications with your doctor or pharmacist before adding this supplement.

If you're pregnant or breastfeeding, the safety data just isn't there yet, so bring this question to your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mulberry Leaf Extract 500 mg, straight from the product label.

Brand Best Naturals
Barcode (UPC) 817716013008
Net contents 120 Vcap(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 269916
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mulberry Leaf Extract 500 mg by Best Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vcap(s)
Maximum serving Sizes:
2 Vcap(s)
Servings per container
60
UPC/BARCODE
817716013008
IngredientAmount% DV
Mulberry Leaf Extract1000 mg--

Other ingredients: Cellulose, Silica, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Mulberry Leaf has been used as a health-promoting tonic in Asia for many years. Mulberry is a rich source of antioxidants, proteins and fibers. Mulberry extract contains moranoline, a key active that delays carbohydrate absorption and promotes healthy blood sugar levels.

Formulation

Supports healthy blood sugar level Supports appetite control Supports cardiovascular health Supports energy and muscle endurance

Weight management

Supports healthy blood sugar level

No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no corn, no soy, no egg, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take two (2) capsules one to two times daily, preferably with meals, or as directed by your qualified healthcare professional.

Precautions

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur.

Storage

Keep in cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to cure, prevent, treat or diagnose any disease.

Seals/Symbols

Made in USA

GMP Good Manufacturing Practice Product

FDA Statement of Identity

Dietary Supplement

General Statements

For additional information call 1-877-659-6004

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mulberry Leaf Extract 500 mg by Best Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mulberry Leaf Extract 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mulberry Leaf Extract 500 mg by Best Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vcap(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Mulberry Leaf Extract

Interacts with
87 drugs
1000 mg per serving Form: Alkaloids, Flavonoids

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is gen...

Mulberry Leaf Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mulberry Leaf Extract 500 mg by Best Naturals Drug Interactions

Want to check YOUR meds against Mulberry Leaf Extract 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Mulberry Leaf Extract 87

Individual Drug Interactions

The ingredients in Mulberry Leaf Extract 500 mg interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Mulberry Leaf Extract 500 mg interact with drugs. Each result below shows which ingredient is responsible. Mulberry Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Mulberry Leaf Extract 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mulberry Leaf Extract2 drug types · 87 drugs

Antidiabetes Drugs

Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that white mulberry leaf can lower blood glucose levels. Advise patients to monitor glucose levels closely.

Likelihood Possible Evidence D
Organic Cation Transporter 2 (Oct2) Substrates

Theoretically, white mulberry leaf might slow the elimination and increase the adverse effects of drugs which are OCT2 substrates.
Animal research shows that coadministration of white mulberry leaf extract with metformin, an OCT2 substrate, slows the renal elimination of metformin via inhibition of OCT2 activity. OCT2 is expressed in the kidneys and is responsible for transporting cationic drugs into tubular epithelial cells in order to be excreted in the urine.

Likelihood Possible Evidence D
Mulberry Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mulberry Leaf Extract 500 mg, from the product label.

Best Naturals

See all Best Naturals products
Name
Best Naturals
Street Address
PO Box 394
City
Kenilworth
State
NJ
ZipCode
07033
Phone Number
1-877-659-6004
Web Address
www.shopbestnaturals.com
Pharmacist Counseling Corner

Mulberry Leaf Extract 500 mg by Best Naturals: Common Questions

Does Mulberry Leaf Extract 500 mg by Best Naturals interact with any medications?
Yes. Based on its ingredients, Mulberry Leaf Extract 500 mg has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mulberry Leaf Extract 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this lower my blood sugar if I don't have diabetes?
Mulberry leaf can lower blood glucose in general, so theoretically there's a risk — though the safety data we hold doesn't detail what happens in people without diabetes. If you don't take diabetes medication and you're concerned, mention it to your doctor before starting, especially if you have a family history of blood sugar problems.
Is it safe during pregnancy or while breastfeeding?
There isn't enough safety data on concentrated mulberry leaf supplements during pregnancy or breastfeeding. The safety information advises against medicinal amounts in both cases. Talk with your doctor or pharmacist for personalized advice if you're pregnant, planning to become pregnant, or nursing.
What side effects should I watch for?
Mild digestive upset — bloating, gas, loose stools, or constipation — is the main thing. One study showed about half of people had bloating or gas early on, a quarter had loose stools, and a fifth had constipation, but these effects often eased as people continued taking it.
Does mulberry leaf really work for blood sugar or cholesterol?
The evidence we hold doesn't establish that it works for diabetes, high cholesterol, or any of the other conditions it's marketed for. If you're thinking about using it for blood sugar control, ask your doctor what the current research actually shows.
Is metformin safe to take with this?
Metformin and mulberry leaf interact at a moderate level. Animal studies show mulberry leaf can slow your kidneys' clearance of metformin, potentially raising it to higher levels in your blood. Don't add this supplement without checking with your doctor or pharmacist first — they can decide if it's okay for you and whether you need extra monitoring.
Why does the interaction list mention 87 medications if there's only one ingredient?
One ingredient can interact with many drugs, and mulberry leaf affects two entire drug categories — diabetes medications and a group of kidney-transport drugs (OCT2 substrates) — which together include 87 individual drugs. That's why the count is higher than you'd expect.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mulberry Leaf Extract 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mulberry Leaf Extract 500 mg label
Go deeper

The Full Monographs Behind Mulberry Leaf Extract 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

White Mulberry

Interacts with 87 drugs

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is generally well tolerated as a food and tea,...

Read the full White Mulberry monograph →
Sources

Sources & How We Checked

Mulberry Leaf Extract 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

White Mulberry 6 references
  1. Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. PubMed
  2. Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. PubMed
  3. Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. PubMed
  4. Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. 2020;12(1):49. PubMed
  5. Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292. PubMed
  6. Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 2021;18(1):41. PubMed

See these in context on the White Mulberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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