Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Multi-Acidophilus Powder Ingredients & Drug Interactions

by Solgar

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Multi-Acidophilus Powder is a dietary supplement by Solgar with 4 active ingredients. Its ingredients are commonly taken for diarrhea relief, constipation and digestive health, cholesterol support.Based on those ingredients, 188 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L. acidophilus LA-5, B. bifidum BB-12, Citrus Pectin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Multi-Acidophilus Powder by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 4 active ingredients.
  • “Multi-Acidophilus Complex” is a proprietary blend — the label gives one combined amount (1.50 Gram(s)) without saying how much of each component you get.

This powder contains four active ingredients: citrus pectin (a soluble fiber from citrus fruit) and three probiotic strains — L. acidophilus LA-5, L. rhamnosus LGG, and B. bifidum BB-12 — all of which are live beneficial bacteria meant to support gut health. The product also contains two inactive ingredients, maltodextrin and silica, which help stabilize and mix the powder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: maintain normal intestinal flora and digestive health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Diarrhea — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The citrus pectin in this blend is possibly effective for high cholesterol, though the evidence isn't ironclad. The three probiotic strains have varying support in the data.

L. acidophilus and B. bifidum are each possibly effective for irritable bowel syndrome, and L. acidophilus is additionally possibly effective for antibiotic-associated diarrhea, bacterial vaginosis, and H. pylori infection. B. bifidum is possibly effective for respiratory tract infections.

For other uses like hay fever, anxiety, or Alzheimer's disease, the evidence either isn't there yet or is too limited to say whether these probiotics help.

The evidence, ingredient by ingredient Pectin Lactobacillus Acidophilus Bifidobacterium Bifidum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Citrus pectin is generally well tolerated at typical supplement doses, though some people experience mild gas, loose stools, diarrhea, or cramping. Allergic reactions are rare but can happen in sensitive individuals.

The two probiotics we checked — L. acidophilus and B. bifidum — are generally well tolerated in healthy adults and children. Uncommon side effects from probiotics include bloating, gas, abdominal discomfort, and diarrhea.

Because these are live organisms, there's a theoretical risk of infection in people with severely weakened immune systems, though this is very rare. For pregnancy and breastfeeding, pectin from food and typical amounts are likely safe, but concentrated supplement safety hasn't been well studied — check with your doctor.

We don't have pregnancy or breastfeeding data on file for the probiotic strains, so talk with your pharmacist for personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Pectin Lactobacillus Acidophilus Bifidobacterium Bifidum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Pectin, Lactobacillus Acidophilus, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 188 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check if you're on lovastatin, tetracycline antibiotics, or digoxin — citrus pectin can reduce how well your body absorbs these. If you're taking any antibiotics, space them out from this supplement by a couple of hours, since the live probiotics can be killed off by the drugs.

Run your complete medication list through the checker on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic and fiber blend may help with digestive issues like IBS or antibiotic-associated diarrhea, and the pectin may support cholesterol management. If you take lovastatin, tetracycline antibiotics, digoxin, or any other regular medication, check your drugs against the interaction tool before starting — the pectin and probiotics can interfere with several common prescriptions.

People with very weak immune systems should ask their doctor before taking it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Multi-Acidophilus Powder, straight from the product label.

Brand Solgar
Barcode (UPC) 033984017863
Net contents 4 Oz(s); 113 Gram(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214664
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Multi-Acidophilus Powder by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 tsp
Maximum serving Sizes:
0.5 tsp
Servings per container
75
UPC/BARCODE
033984017863
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Citrus Pectin50 mg--
Multi-Acidophilus Complex1.5 Gram(s)--
L. acidophilus LA-50 NP--
L. rhamnosus LGG0 NP--
B. bifidum BB-120 NP--

Other ingredients: Maltodextrin, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Solgar's Multi-Acidophilus Powder is free of yeast, wheat, soy, gluten and dairy products and is formulated without the use of artificial preservatives, flavors or colors.

This product is sold by weight, not by volume - therefore, settling will occur.

Enhanced series

100% Dairy, lactose and milk free (No casein)

Suitable for vegetarians

Sugar, salt and starch free

Contains no major allergens.

Formula

Solgar's Multi-Acidophilus Powder supplies beneficial microorganisms, such as L. acidophilus and L. rhamnosus, which help maintain a normal flora in the intestinal tract. Our specially designed formula includes citrus pectin, a soluble dietary fiber.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

To assure freshness and potency, refrigerate after opening.

Precautions

Do not use if outer bottle seal is missing, torn or damaged in any way.

If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

General Statements

Solgar since 1947

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement for adults, take one half (1/2) teaspoon (1.5 g) one to three times daily, preferably between meals or as directed by a healthcare practitioner. Mix with water.

Brand IP Statement(s)

BB-12 and LA-5 are registered trademarks of Chr. Hansen. LGG is a trademark of Valio Ltd.

See for yourself

Multi-Acidophilus Powder by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Multi-Acidophilus Powder by Solgar

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.5 tsp Dosage formPowder Servings per container75 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Citrus Pectin

Interacts with
23 drugs
50 mg per serving

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly he...

Citrus Pectin monograph & interactions

Multi-Acidophilus Complex

1.5 Gram(s) per serving

Other (inactive) ingredients: Maltodextrin, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Multi-Acidophilus Powder by Solgar Drug Interactions

Want to check YOUR meds against Multi-Acidophilus Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
188Drugs
188 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Multi-Acidophilus Powder with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L. acidophilus LA-51 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D

B. bifidum BB-121 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D

Citrus Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Multi-Acidophilus Powder, from the product label.

Solgar

See all Solgar products
Name
Solgar, Inc.
Street Address
500 Willow Tree Road
City
Leonia
State
NJ
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

Multi-Acidophilus Powder by Solgar: Common Questions

Does Multi-Acidophilus Powder by Solgar interact with any medications?
Yes. Based on its ingredients, Multi-Acidophilus Powder has a known interaction with 188 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Multi-Acidophilus Powder contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's in this powder — is it just probiotics?
No, it's a blend. You get citrus pectin, which is a soluble fiber, plus three probiotic strains — L. acidophilus LA-5, L. rhamnosus LGG, and B. bifidum BB-12 — all designed to support your gut. The powder also contains maltodextrin and silica as inactive ingredients to keep it stable.
Can I take this if I'm on antibiotics?
You can, but timing matters. Since antibiotics can kill off the live probiotics, space them out by a couple of hours — take your antibiotic, wait, then take the probiotic (or vice versa). That way the probiotic bacteria have a better chance of surviving. Ask your pharmacist about the best schedule for your specific antibiotic.
Will this help my IBS?
The L. acidophilus and B. bifidum in here are possibly effective for irritable bowel syndrome based on available evidence, so it's worth trying — but results vary from person to person. If you don't notice improvement after a few weeks, it may not be the right fit for you.
Is this safe if I'm pregnant?
The pectin in typical supplement amounts is likely safe in pregnancy, but concentrated supplement safety hasn't been well studied, so check with your doctor. We don't have pregnancy data on file for the probiotic strains, so ask your doctor or pharmacist for personalized advice.
What side effects should I watch for?
Most people tolerate this well. You might notice mild gas, bloating, loose stools, diarrhea, or mild stomach cramps — these are usually harmless and often settle down. Allergic reactions are rare but can happen in sensitive people. If you develop a rash, itching, or trouble breathing, stop and call your doctor right away.
Does this work for my cholesterol?
The pectin in this blend is possibly effective for high cholesterol, though it's not a guaranteed fix. If lowering cholesterol is your main goal, check with your doctor about whether it's worth adding to your routine, especially if you're already on a statin.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Multi-Acidophilus Powder is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Multi-Acidophilus Powder label
Sources

Sources & How We Checked

Multi-Acidophilus Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 33 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pectin 11 references
  1. Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
  2. Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
  3. Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
  4. Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
  5. Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
  6. Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  7. Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
  8. Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
  9. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  10. Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  11. Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed

See these in context on the Pectin monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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