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Dietary supplement

NAD+ Cell Regenerator Ingredients & Drug Interactions

by Life Extension

Capsule Category: Vitamin
Most serious interaction: Minor
The interaction bottom line Most serious interaction: Minor

NAD+ Cell Regenerator is a dietary supplement by Life Extension with 1 active ingredient. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are NIAGEN Nicotinamide Riboside. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of NAD+ Cell Regenerator by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: NIAGEN nicotinamide riboside, a form of vitamin B3. Nicotinamide riboside is intended to support cellular energy production and regeneration.

The capsule also contains inactive ingredients — microcrystalline cellulose, vegetable cellulose, vegetable stearate, and silica — which are fillers and binders that hold the supplement together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Nicotinamide Riboside product and its label doesn't state a use — see Nicotinamide Riboside's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold does not establish that nicotinamide riboside is effective for any of the conditions it's marketed for — age-related macular degeneration (AMD), Alzheimer's disease, athletic performance, nonalcoholic fatty liver disease (NAFLD), or heart failure. For all of these, the data is rated insufficient.

That doesn't mean it doesn't work; it means the research to prove it isn't solid enough yet.

The evidence, ingredient by ingredient Nicotinamide Riboside

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nicotinamide riboside appears well tolerated in short-term studies, but long-term safety isn't fully known. The most common side effects reported in trials are bloating, muscle pain, nausea, itching, sweating, and changes in bowel habits — most mild and temporary.

A small number of trial participants reported leg cramps or muscle soreness. The safety data advises against use during pregnancy and while breastfeeding, since there isn't enough information to confirm it's safe at those times.

Side effects, ingredient by ingredient Nicotinamide Riboside

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nicotinamide Riboside.
  • The most serious interaction on file is rated Minor.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antihypertensive drugs (blood pressure medications), confirm with your doctor or pharmacist before adding this product — nicotinamide riboside may lower your blood pressure further and raise the risk of dizziness or lightheadedness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

NAD+ Cell Regenerator may be worth considering if you're interested in cellular health support, though the evidence for any specific health claim isn't established yet. If you take blood pressure medication, you'll want to check with your doctor or pharmacist first — nicotinamide riboside could add to its effect.

Pregnant or breastfeeding people should avoid it. Talk it over with your own healthcare provider to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NAD+ Cell Regenerator, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870234432
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232682
Product type Vitamin
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NAD+ Cell Regenerator by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
737870234432
IngredientAmount% DV
NIAGEN Nicotinamide Riboside300 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. Directions: Take one (1) capsule daily, or as recommended by a healthcare practitioner.

Formula

Nicotinamide Riboside does not cause flushing.

Precautions

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Gluten free Non GMO LE Certified

300 mg Defense against cellular aging

Seals/Symbols

Non GMO LE Certified

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

NIAGEN is a registered trademark of ChromaDex, Inc., Patents see: www.ChromaDexPatents.com.

Storage

Store tightly closed in a cool, dry place.

See for yourself

NAD+ Cell Regenerator by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in NAD+ Cell Regenerator by Life Extension

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

NIAGEN Nicotinamide Riboside

Interacts with
172 drugs
300 mg per serving

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...

NIAGEN Nicotinamide Riboside monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

NAD+ Cell Regenerator by Life Extension Drug Interactions

Want to check YOUR meds against NAD+ Cell Regenerator?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
172Drugs
172 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in NAD+ Cell Regenerator with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

NIAGEN Nicotinamide Riboside1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for NAD+ Cell Regenerator, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

NAD+ Cell Regenerator by Life Extension: Common Questions

Does NAD+ Cell Regenerator by Life Extension interact with any medications?
Yes. Based on its ingredients, NAD+ Cell Regenerator has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NAD+ Cell Regenerator contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is nicotinamide riboside, and what is it supposed to do?
Nicotinamide riboside (NIAGEN) is a form of vitamin B3 designed to support your cells' energy production and regeneration at the cellular level. It's meant to help with age-related health concerns, though the evidence for specific benefits isn't established yet.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against it. There isn't enough information to know whether nicotinamide riboside is safe during pregnancy or while breastfeeding, so talk with your doctor or pharmacist about your options.
What side effects should I expect?
The most common ones reported in trials are mild and temporary: bloating, muscle pain, nausea, itching, sweating, and changes in your bowel habits. A small number of people reported leg cramps or muscle soreness. Most people tolerate it well in the short term.
Is this supplement effective for age-related macular degeneration or Alzheimer's disease?
The evidence we hold doesn't establish that it is. For both conditions, as well as athletic performance, fatty liver disease, and heart failure, the research so far is rated insufficient. That doesn't mean it won't work someday — just that we don't have solid proof yet.
How long has this been studied for safety?
Nicotinamide riboside appears well tolerated in short-term studies, but long-term safety data isn't fully available. If you're thinking of taking it long-term, that's worth discussing with your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if NAD+ Cell Regenerator is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NAD+ Cell Regenerator label
Sources

Sources & How We Checked

NAD+ Cell Regenerator's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nicotinamide Riboside 7 references
  1. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
  2. Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
  3. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
  4. Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
  5. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
  6. Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
  7. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.

See these in context on the Nicotinamide Riboside monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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