Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Nattokinase 100 mg Ingredients & Drug Interactions

by Allergy Research Group

Nattokinase 100 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nattokinase 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nattokinase 100 mg is a dietary supplement by Allergy Research Group with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Nattokinase 100 mg by Allergy Research Group

Ask about any prescription or over-the-counter medication and we check it for interactions with Nattokinase 100 mg by Allergy Research Group — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Nattokinase 100 mg by Allergy Research Group

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: nattokinase 100 mg per softgel, an enzyme derived from natto (fermented soybeans). Nattokinase is used in supplements for its potential effects on blood flow and clotting.

The softgel also contains inactive ingredients — soybean oil, gelatin, glycerin, soybean lecithin, glycerin fatty acid ester, and beeswax — which are typical capsule materials and carriers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Heart and circulatory health support.
  • We looked for evidence on: Angina, Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Peripheral arterial disease (PAD) — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence we hold for nattokinase in a range of uses — including angina, atherosclerosis, cancer prevention, cardiovascular disease, and chronic fatigue syndrome — is rated insufficient reliable evidence to rate. That means the current data doesn't establish whether it works for these conditions.

If you're considering it for a specific health goal, discuss what the research shows with your doctor or pharmacist.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated over the short term, but its blood-thinning effect means it's not suitable for people at risk of bleeding. Rare reports of bleeding, including one severe case of brain hemorrhage, have been documented.

Additionally, people sensitive to natto (fermented soybeans) can have hypersensitivity reactions, ranging from throat swelling to anaphylaxis, usually within 2 hours of taking it. There isn't enough safety data to recommend nattokinase during pregnancy, so it's best avoided.

Safety while breastfeeding is also unknown, so avoid it during breastfeeding as well. If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before considering this product.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs — including aspirin, warfarin, and other anticoagulants — because nattokinase may increase bleeding risk, with at least one severe case documented. Also confirm any blood pressure medications you're on, since nattokinase may lower blood pressure further and increase the risk of low blood pressure symptoms.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Nattokinase may be worth considering if you're interested in blood flow support — but only after you've cleared it with your doctor or pharmacist, especially if you take blood pressure medications or any blood thinners. The documented risk of serious bleeding when combined with aspirin or other anticoagulants means this isn't a casual add-on.

People with bleeding disorders or natto allergies should avoid it entirely. Check your exact medications against this product's interactions before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nattokinase 100 mg, straight from the product label.

Brand Allergy Research Group
Barcode (UPC) 713947753808
Net contents 180 Softgel(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 258307
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nattokinase 100 mg by Allergy Research Group, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
180
UPC/BARCODE
713947753808
IngredientAmount% DV
Nattokinase100 mg--

Other ingredients: Soybean Oil, Gelatin, Glycerin, Soybean Lecithin, Glycerin Fatty Acid Ester, Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Isolated, purified and encapsulated nattokinase, an enzyme derived from boiled soybeans using a selected, patented strain of Bacillus subtilis natto. Nattokinase NSK-SD is vegetarian, non-irradiated, and free of vitamin K2.

NSK-SD 2000 FU

Formulation

Nattokinase NSK-SD is vegetarian, non-irradiated, and free of vitamin K2.

Nattokinase NSK-SD is vegetarian, non-irradiated, and free of vitamin K2.

Product of Japan.

Brand IP Statement(s)

NSK-SD is a trademark of Japan BioScience Laboratory.

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, 1 softgel two times daily initial dose, or as directed by a healthcare practitioner. May be taken with or without food. Take with 8 to 10 ounces of water.

Precautions

If taken with anticoagulant drugs, use under medical supervision.

Contraindicated in any condition associated with bleeding.

Contains: Soy.

Storage

Store in a cool, dry place, tightly capped.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nattokinase 100 mg by Allergy Research Group label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nattokinase 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nattokinase 100 mg by Allergy Research Group

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container180 Amounts shown are per serving.

Nattokinase

Interacts with
289 drugs
100 mg per serving Form: Soy

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Soybean Lecithin, Glycerin Fatty Acid Ester, Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nattokinase 100 mg by Allergy Research Group Drug Interactions

Want to check YOUR meds against Nattokinase 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289

Individual Drug Interactions

The ingredients in Nattokinase 100 mg interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nattokinase 100 mg interact with drugs. Each result below shows which ingredient is responsible. Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in Nattokinase 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nattokinase 100 mg, from the product label.

Allergy Research Group

See all Allergy Research Group products
Name
Allergy Research Group
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800.545.9960
Web Address
www.allergyresearchgroup.com
Pharmacist Counseling Corner

Nattokinase 100 mg by Allergy Research Group: Common Questions

Does Nattokinase 100 mg by Allergy Research Group interact with any medications?
Yes. Based on its ingredients, Nattokinase 100 mg has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nattokinase 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take nattokinase if I'm allergic to soy?
Nattokinase comes from fermented soybeans (natto), and people sensitive to natto have reported hypersensitivity reactions — some serious, including anaphylaxis. Symptoms typically occur within 2 hours. If you have a soy or natto allergy, this product isn't safe for you. Talk with your allergist or pharmacist if you're unsure about your soy sensitivity.
Is nattokinase safe during pregnancy or while breastfeeding?
No — there isn't enough safety data. It's best avoided in pregnancy, and safety while breastfeeding is unknown, so you should avoid it then too. If you're pregnant, planning pregnancy, or breastfeeding, speak with your doctor or pharmacist before considering nattokinase.
What does nattokinase do?
Nattokinase is an enzyme from fermented soybeans that supplements claim may support blood flow and clotting. However, the evidence we hold for its effectiveness in treating specific conditions — from angina to heart disease to chronic fatigue — is rated insufficient reliable evidence to rate, meaning we don't have enough data to confirm it works.
Can I take nattokinase with aspirin?
No — the data shows a real risk. There's a documented case of a patient who developed severe brain bleeding after adding nattokinase to low-dose aspirin therapy. Nattokinase has blood-thinning effects that can compound aspirin's, raising bleeding risk significantly. Do not combine these without explicit approval from your doctor.
What are the side effects of nattokinase?
Nattokinase is generally well tolerated short-term, but bleeding is the main concern — rare reports exist, including one severe case of brain hemorrhage. Hypersensitivity reactions to natto are also possible, with symptoms like throat swelling occurring within 2 hours in sensitive individuals. If you experience unusual bruising, bleeding, or throat swelling after taking it, stop and seek medical care.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nattokinase 100 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nattokinase 100 mg label
Go deeper

The Full Monographs Behind Nattokinase 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Nattokinase 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team