Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Nattokinase NSK-SD Ingredients & Drug Interactions

by Pure Prescriptions

Nattokinase NSK-SD label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nattokinase NSK-SD against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nattokinase NSK-SD is a dietary supplement by Pure Prescriptions with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are NSK-SD Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Nattokinase NSK-SD by Pure Prescriptions

Ask about any prescription or over-the-counter medication and we check it for interactions with Nattokinase NSK-SD by Pure Prescriptions — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Nattokinase NSK-SD by Pure Prescriptions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Nattokinase NSK-SD by Pure Prescriptions contains one active ingredient: NSK-SD nattokinase, a protein-digesting enzyme derived from fermented soybeans. The capsule itself is made from vegetable cellulose, and rice flour is included as an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Heart and circulatory health support.
  • We looked for evidence on: Angina, Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Peripheral arterial disease (PAD) — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence we have doesn't establish whether nattokinase works for any of its proposed uses—angina, atherosclerosis, cancer, cardiovascular disease, or chronic fatigue syndrome all carry insufficient reliable evidence ratings in our data. That doesn't mean it doesn't work; it means the evidence isn't solid enough for us to rate it one way or the other.

Talk with your doctor about whether this product makes sense for your specific health goal.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated in the short term, but because of its blood-thinning effects, it carries caution for anyone at higher risk of bleeding. Rare cases of hemorrhage—including brain bleeding—have been reported, particularly when combined with other blood thinners.

If you have a history of bleeding problems or take blood thinners, this is something to discuss with your doctor before starting. Not enough safety data exists for pregnancy or breastfeeding.

The safety notes advise against use during both. Talk with your doctor or pharmacist about your individual situation if you're pregnant, planning pregnancy, or breastfeeding.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before starting if you take blood thinners (anticoagulants) like warfarin or aspirin, or any antiplatelet drugs—there's a Moderate risk of bleeding. Also flag any blood pressure medications you're on, since nattokinase may lower pressure further, creating a Moderate risk of blood pressure dropping too low.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Nattokinase is an enzyme with blood-thinning and blood pressure-lowering properties. If you take blood thinners or blood pressure medications, you need to check with your doctor or pharmacist before starting this product—the interaction risk is real.

The effectiveness for heart health and other conditions isn't established in the data we hold. Discuss with your own healthcare provider whether nattokinase is appropriate for you and your medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nattokinase NSK-SD, straight from the product label.

Brand Pure Prescriptions
Barcode (UPC) 852980001269
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 228206
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nattokinase NSK-SD by Pure Prescriptions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
852980001269
IngredientAmount% DV
NSK-SD Nattokinase100 mg--

Other ingredients: Vegetable Capsule, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Nattokinase is an enzyme that is extracted from the fermented soy food called “natto.” Natto is regarded by the Japanese as a very healthy food and has been consumed there for centuries. Nattokinase was ?rst discovered by Dr. Hiroyuki Sumi. M.D., PhD. Natto has been used traditionally to support cardiovascular health. Modern research has revealed that nattokinase works by breaking down fibrin, a protein Involved in clotting of the blood.

Professional grade

Supports healthy blood flow & cardiovascular health

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 capsule, 2 times daily, 12 hours apart, or between meals.

Precautions

Read First: Do not expose to excessive heat.

Keep out of reach of children.

Consult with your doctor if you are pregnant or nursing.

Allergen statement: This product contains soy.

General Statements

Natural health solutions

100 mg /capsule

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

NSK-SD is registered trademark of Japan Bio Science Laboratories.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nattokinase NSK-SD by Pure Prescriptions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nattokinase NSK-SD label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nattokinase NSK-SD by Pure Prescriptions

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

NSK-SD Nattokinase

Interacts with
289 drugs
100 mg per serving

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

NSK-SD Nattokinase monograph & interactions

Other (inactive) ingredients: Vegetable Capsule, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nattokinase NSK-SD by Pure Prescriptions Drug Interactions

Want to check YOUR meds against Nattokinase NSK-SD?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

NSK-SD Nattokinase 289

Individual Drug Interactions

The ingredients in Nattokinase NSK-SD interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nattokinase NSK-SD interact with drugs. Each result below shows which ingredient is responsible. NSK-SD Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in Nattokinase NSK-SD with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

NSK-SD Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
NSK-SD Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nattokinase NSK-SD, from the product label.

Pure Prescriptions

See all Pure Prescriptions products
Name
Pure Prescriptions, Inc.
Phone Number
1.800.860.9583
Web Address
www.PurePrescriptions.com
Pharmacist Counseling Corner

Nattokinase NSK-SD by Pure Prescriptions: Common Questions

Does Nattokinase NSK-SD by Pure Prescriptions interact with any medications?
Yes. Based on its ingredients, Nattokinase NSK-SD has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nattokinase NSK-SD contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take nattokinase with aspirin?
No—combining nattokinase with aspirin or any blood thinner carries a Moderate risk of bleeding. There's even a documented case of brain bleeding when someone took nattokinase with low-dose aspirin. Talk with your doctor before taking this product if you're on aspirin or any blood thinner.
Will nattokinase lower my blood pressure?
Some clinical research suggests nattokinase may reduce blood pressure. If you already take medication to manage high blood pressure, adding nattokinase could push it lower than intended. Check with your doctor or pharmacist first.
Is nattokinase safe during pregnancy?
No—the safety notes advise against it during pregnancy because there isn't enough safety data. If you're pregnant or planning to become pregnant, talk with your doctor or pharmacist before taking this product.
Can I take nattokinase while breastfeeding?
No—safety while breastfeeding is unknown, so the recommendation is to avoid it. If you're breastfeeding and interested in nattokinase, ask your doctor or pharmacist whether it's appropriate for your situation.
What if I'm allergic to soy or natto?
Nattokinase is derived from fermented soybeans (natto), and rare hypersensitivity reactions—including anaphylaxis—have been reported in people sensitive to natto. Symptoms can start within 2 hours. If you have a known soy or natto allergy, do not take this product.
Does nattokinase actually work for heart disease?
The evidence we hold shows insufficient reliable evidence for cardiovascular disease, angina, and atherosclerosis. That means we don't have solid proof it works for those conditions. Talk with your doctor about whether nattokinase is supported by science for your particular health goal.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nattokinase NSK-SD is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nattokinase NSK-SD label
Go deeper

The Full Monographs Behind Nattokinase NSK-SD’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Nattokinase NSK-SD's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team