Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

NattoRepair Ingredients & Drug Interactions

by Warrior Essentials

NattoRepair label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NattoRepair against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

NattoRepair is a dietary supplement by Warrior Essentials with 3 active ingredients. Its ingredients are commonly taken for constipation and regularity, prebiotic gut health, blood sugar support.Based on those ingredients, 394 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattozimes, Bromelain Proteolytic Enzyme extract, Inulin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against NattoRepair by Warrior Essentials

Ask about any prescription or over-the-counter medication and we check it for interactions with NattoRepair by Warrior Essentials — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of NattoRepair by Warrior Essentials

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

NattoRepair contains three active ingredients. Inulin is a plant fiber that may support blood sugar control and digestive health.

Nattozimes (listed as nattokinase) is an enzyme derived from fermented soy that may affect blood flow and blood pressure. Bromelain is a proteolytic enzyme extracted from pineapple that works to break down proteins.

The product also contains inactive ingredients—purified water, hypromellose (a capsule binder), and rice husk—which serve as excipients to hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Constipation — rated "Possibly Effective" (Inulin) (Natural Medicines).
  • On file: Diabetes — rated "Possibly Effective" (Inulin) (Natural Medicines).
  • On file: Obesity — rated "Possibly Effective" (Inulin) (Natural Medicines).

The evidence for this product is mixed and mostly limited. Inulin is possibly effective for obesity, constipation, and diabetes support based on available research, though its blood-sugar effects aren't conclusive.

For nattokinase, we hold insufficient evidence to rate its effectiveness for angina, atherosclerosis, cardiovascular disease, cancer, or chronic fatigue—the research just isn't solid enough yet. Bromelain likewise has insufficient evidence for allergic rhinitis, burns, cancer, chemotherapy-related nerve damage, chronic venous insufficiency, and diabetes.

In short, while these ingredients show some promise, we don't have strong evidence backing most of the conditions it may be marketed for.

The evidence, ingredient by ingredient Inulin Nattokinase Bromelain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Inulin is likely safe during pregnancy and lactation in food amounts, though concentrated supplement doses haven't been well studied—it's generally well tolerated but often causes gas, bloating, diarrhea, and constipation, especially at higher doses over 30 grams. Anaphylaxis after inulin is rare but has been reported.

Nattokinase carries more caution: it's best avoided during pregnancy due to insufficient safety data, and should be avoided while breastfeeding because safety is unknown. It's generally tolerated short-term, but its blood-thinning effect poses risk for people prone to bleeding.

Rare reports of hemorrhage exist, including a documented case of bleeding in the brain. Hypersensitivity reactions, including anaphylaxis, can occur in people sensitive to natto or its components.

Bromelain is best avoided during pregnancy and while breastfeeding due to lack of safety data. Short-term it's generally well tolerated, but long-term evidence is sparse.

Common side effects are diarrhea, gas, stomach upset, and headache; allergic reactions (including asthma if inhaled) are possible, especially in people with pineapple sensitivity.

Side effects, ingredient by ingredient Inulin Nattokinase Bromelain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Bromelain, Inulin, Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 394 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking NattoRepair, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (warfarin, clopidogrel, aspirin)—nattokinase and bromelain both raise bleeding risk. If you're on diabetes medications, inulin may theoretically lower blood sugar further.

If you take tetracycline antibiotics, bromelain might increase their levels. High blood pressure drugs warrant caution too, since nattokinase may lower blood pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

NattoRepair may appeal to someone looking for enzyme and fiber support, but it's not for everyone. If you take blood thinners, diabetes medications, tetracycline antibiotics, or blood pressure drugs, you'll need to talk this over with your doctor or pharmacist first—the interactions can be real.

Avoid it during pregnancy and breastfeeding. Even if you're not on those medications, check your exact regimen with the tool on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NattoRepair, straight from the product label.

Brand Warrior Essentials
Barcode (UPC) 671891121695
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 314155
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NattoRepair by Warrior Essentials, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
671891121695
IngredientAmount% DV
Inulin30 mg--
Nattozimes58 mg--
Bromelain Proteolytic Enzyme extract105 mg--

Other ingredients: Water, Purified, Hypromellose, Rice Husk

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Adults take 1 capsule 2 times daily, without food or between meals, with a full glass of water, or as directed by your healthcare provider.

Precautions

Warning: Consult your healthcare provider prior to using this product is you are taking blood-thinning medications or have a bleeding disorder. While there is no evidence that Nattozimes poses any risks to children, developing fetuses, or women who are pregnant or nursing, as with any dietary supplement, consult your healthcare practitioner before using this product, especially if you anticipate surgery, take medicine regularly or are otherwise under medical supervision.

Do not use or handle this product if you are allergic to aspergillus.

While there is no evidence that Nattozimes poses any risks to children, developing fetuses, or women who are pregnant or nursing, as with any dietary supplement, consult your healthcare practitioner before using this product, especially if you anticipate surgery, take medicine regularly or are otherwise under medical supervision. Keep out of reach of children.

Do not use if safety seal is missing or broken.

Mfg. in a facility that processes milk, soy, eggs, peanut, sesame, shellfish, tree nuts & wheat.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Formulated in the USA with the finest U.S. and globally sourced ingredients and proudly manufactured in an FDA registered facility.

This is a dietary supplement, not a drug. No artificial colors or preservatives.

Made in a cGMP & FDA registered facility

Spike support series

General Statements

Package size is determined by labeling information, not the number of servings in this container. Serving size and contents are clearly marked.

30-day supply

FU = enzyme activity in Fibrolytic Units. GDU = enzyme activity in Gelatin Digestive Units

Seals/Symbols

Formulated in the USA

Brand IP Statement(s)

Copyright 2023 Warrior Essentials LLC

Nattozimes is a registered Trademark of Deerland Probiotics & Enzymes.

Formula

Proteolytic enzymes

NattoRepair is a Protease enzyme blend formulated to support cardiovascular health and to match 1:1 the fibrinolytic (anti-clotting) activity of nattokinase to help maintain a healthy immune system.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NattoRepair by Warrior Essentials label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NattoRepair label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NattoRepair by Warrior Essentials

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Inulin

Interacts with
86 drugs
30 mg per serving

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements an...

Inulin monograph & interactions

Nattozimes

Interacts with
289 drugs
58 mg per serving Form: Endopeptidase, Exopeptidase

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattozimes monograph & interactions

Bromelain Proteolytic Enzyme extract

Interacts with
141 drugs
105 mg per serving Form: Pineapple

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early st...

Bromelain Proteolytic Enzyme extract monograph & interactions

Other (inactive) ingredients: Water, Purified, Hypromellose, Rice Husk. These complete the product’s ingredient list but are not active constituents.

Interaction report

NattoRepair by Warrior Essentials Drug Interactions

Want to check YOUR meds against NattoRepair?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
394Drugs
289 Moderate 105 Minor

Ingredients driving the most interactions

Nattozimes 289
Bromelain Proteolytic Enzyme extract 141
Inulin 86

Individual Drug Interactions

The ingredients in NattoRepair interact with 394 drugs. Click any drug to see the details.

3 of the 3 ingredients in NattoRepair interact with drugs. Each result below shows which ingredient is responsible. Nattozimes Bromelain Proteolytic Enzyme extract Inulin

Each ingredient & the kinds of drugs it affects

For each ingredient in NattoRepair with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattozimes2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattozimes full monograph & interactions

Bromelain Proteolytic Enzyme extract2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain Proteolytic Enzyme extract full monograph & interactions

Inulin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Some clinical research shows that inulin improves glycemic control in patients with diabetes; however, it is unclear if it has hypoglycemic effects.

Likelihood Unlikely Evidence D
Inulin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NattoRepair, from the product label.

Warrior Essentials

See all Warrior Essentials products
Name
Warrior Essentials LLC
Street Address
2232 Dell Range Blvd., Ste 245
City
Cheyenne
State
WY
ZipCode
82009
Web Address
www.mywarrioressentials.com
Pharmacist Counseling Corner

NattoRepair by Warrior Essentials: Common Questions

Does NattoRepair by Warrior Essentials interact with any medications?
Yes. Based on its ingredients, NattoRepair has a known interaction with 394 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NattoRepair contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this cause gas and bloating?
Possibly—inulin commonly causes bloating, gas, diarrhea, and stomach cramps, especially at higher doses above 30 grams. If you have a sensitive stomach, start low and go slow, and talk to your pharmacist about timing and dose.
Is this safe if I'm pregnant or breastfeeding?
No. Nattokinase and bromelain should be avoided during pregnancy and breastfeeding because safety data is lacking. Inulin is likely safe in food amounts during pregnancy and lactation, but concentrated supplement doses haven't been well studied. Talk to your doctor before taking any of these as a supplement while pregnant or nursing.
Can I take this with aspirin?
No—don't combine this with aspirin or other blood thinners without talking to your doctor first. Both nattokinase and bromelain can increase bleeding risk, and there's a documented case of someone having bleeding in the brain after mixing nattokinase with aspirin.
What is nattozimes, and what does it do?
Nattozimes is nattokinase, an enzyme from fermented soy that may affect blood flow and blood pressure. Research on whether it actually works for heart health or other conditions isn't strong enough to say for sure yet.
Can this help my blood sugar?
Inulin, one of the three ingredients, is possibly effective for diabetes based on some research, though the evidence isn't definitive. If you're on diabetes medication, check with your pharmacist or doctor first—inulin might theoretically lower blood sugar further.
Are there any serious side effects I should know about?
Serious effects are rare but possible. Anaphylaxis (severe allergic reaction) has occurred with inulin and with nattokinase or bromelain if you're sensitive to natto or pineapple. A documented case of bleeding in the brain occurred when nattokinase was added to aspirin. If you notice unusual bruising, bleeding, difficulty swallowing, or trouble breathing, seek medical attention right away.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if NattoRepair is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NattoRepair label
Go deeper

The Full Monographs Behind NattoRepair’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph → Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph →
Sources

Sources & How We Checked

NattoRepair's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 46 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Inulin 18 references
  1. Williams CM. Effects of inulin on lipid parameters in humans. J Nutr 1999 Jul;129(7 Suppl):1471S-3S. PubMed
  2. Pedersen A, Sandstrom B, Van Amelsvoort JM. The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. Br J Nutr 1997;78:215-22. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. PubMed
  5. Dehghan P, Gargari BP, Jafar-Abadi MA, Aliasgharzadeh A. Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized-controlled clinical trial. Int J Food Sci Nutr 2014;65(1):117-23. PubMed
  6. Guess ND, Dornhorst A, Oliver N, Frost GS. A randomised crossover trial: the effect of inulin on glucose homeostasis in subtypes of prediabetes. Ann Nutr Metab 2016;68(1):26-34. PubMed
  7. Marteau P, Jacobs H, Cazaubiel M, Signoret C, Prevel JM, Housez B. Effects of chicory inulin in constipated elderly people: a double-blind controlled trial. Int J Food Sci Nutr 2011;62(2):164-70. PubMed
  8. Mensink MA, Frijlink HW, van der Voort Maarschalk K, Hinrichs WL. Inulin, a flexible oligosaccharide I: review of its physicochemical characteristics. Carbohydr Polym 2015;130:405-19. PubMed
  9. Slavin J, Feirtag J. Chicory inulin does not increase stool weight or speed up intestinal transit time in healthy male subjects. Food Funct. 2011;2(1):72-7. PubMed
  10. Micka A, Siepelmeyer A, Holz A, Theis S, Schön C. Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial. Int J Food Sci Nutr. 2017;68(1):82-89. PubMed
  11. Smiljanec K, Mitchell CM, Privitera OF, Neilson AP, Davy KP, Davy BM. Pre-meal inulin consumption does not affect acute energy intake in overweight and obese middle-aged and older adults: A randomized controlled crossover pilot trial. Nutr Health. 2017;23 PubMed
  12. Cai X, Yu H, Liu L, et al. Milk powder co-supplemented with inulin and resistant dextrin improves glycemic control and insulin resistance in elderly type 2 diabetes mellitus: a 12-week randomized, double-blind, placebo-controlled trial. Mol Nutr Food Res PubMed
  13. Rao M, Gao C, Xu L, et al. Effect of inulin-type carbohydrates on insulin resistance in patients with type 2 diabetes and obesity: a systematic review and meta-analysis. J Diabetes Res. 2019;2019:5101423. PubMed
  14. Mitchell CM, Davy BM, Ponder MA, et al. Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial. Nutrients 2021;13(9):3235. PubMed
  15. Li L, Li P, Xu L. Assessing the effects of inulin-type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr 2021;9(8):4598-4616. PubMed
  16. Ziaei R, Shahshahan Z, Ghasemi-Tehrani H, Heidari Z, Ghiasvand R. Effects of inulin-type fructans with different degrees of polymerization on inflammation, oxidative stress and endothelial dysfunction in women with polycystic ovary syndrome: A randomized,
  17. Risso D, Kaczmarczyk M, Laurie I, et al. Moderate intakes of soluble corn fibre or inulin do not cause gastrointestinal discomfort and are well tolerated in healthy children. Int J Food Sci Nutr 2022;73(8):1104-1115. PubMed
  18. Isakov VA, Pilipenko VI, Vlasova AV, Kochetkova AA. Evaluation of the efficacy of kombucha-based drink enriched with inulin and vitamins for the management of constipation-predominant irritable bowel syndrome in females: A randomized pilot study. Curr Dev PubMed

See these in context on the Inulin monograph →

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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