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Dietary supplement

NattoZyme Nattokinase 100 mg Ingredients & Drug Interactions

by NutriCology

NattoZyme Nattokinase 100 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NattoZyme Nattokinase 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

NattoZyme Nattokinase 100 mg is a dietary supplement by NutriCology with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase NSK-SD. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against NattoZyme Nattokinase 100 mg by NutriCology

Ask about any prescription or over-the-counter medication and we check it for interactions with NattoZyme Nattokinase 100 mg by NutriCology — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of NattoZyme Nattokinase 100 mg by NutriCology

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

NattoZyme Nattokinase 100 mg contains one active ingredient: nattokinase NSK-SD, an enzyme derived from natto, a fermented soybean food. Nattokinase has fibrinolytic properties — that means it may help break down clots.

The softgel capsule also contains inactive ingredients: soybean oil, gelatin, glycerin, soybean lecithin, glycerin fatty acid ester, and beeswax. If you're allergic to soy or gelatin, check the label carefully.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Heart and circulatory health support.
  • We looked for evidence on: Angina, Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Peripheral arterial disease (PAD) — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence we hold does not establish that nattokinase is effective for the conditions listed on this product — including angina, atherosclerosis, cancer, cardiovascular disease, and chronic fatigue syndrome. For all of these, the data shows insufficient reliable evidence to rate it.

If you're considering this supplement for a specific health concern, talk it over with your doctor or pharmacist about whether the research supports its use for your situation.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated in the short term, but its blood-thinning effect means people with any bleeding risk need to be careful. Rare reports of bleeding, including a serious case of brain hemorrhage, have been linked to nattokinase — especially when combined with blood thinners like aspirin.

Hypersensitivity reactions, including anaphylaxis, can occur in people sensitive to natto or its components; symptoms may show up within 2 hours of taking it, typically affecting the throat and pharynx. There is not enough safety data to use nattokinase during pregnancy or while breastfeeding, so it should be avoided at those times.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking NattoZyme, check with your doctor or pharmacist if you take any blood thinners — prescription anticoagulants (like warfarin), direct oral anticoagulants, or antiplatelet drugs (like aspirin or clopidogrel) — because nattokinase may increase bleeding risk, including serious bleeding inside the brain. Also check if you take blood pressure medications, since nattokinase may lower blood pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

NattoZyme is a single-ingredient nattokinase supplement intended for cardiovascular support, but the evidence we hold doesn't establish that it works for any of the conditions listed. The main safety concern is its blood-thinning effect — if you take blood pressure medications or blood thinners (including aspirin), you need to talk with your doctor or pharmacist before starting it.

If you're pregnant, breastfeeding, or have any history of bleeding, check with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NattoZyme Nattokinase 100 mg, straight from the product label.

Brand NutriCology
Barcode (UPC) 713947553804
Net contents 180 Softgel(s)
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 235448
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NattoZyme Nattokinase 100 mg by NutriCology, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
180
UPC/BARCODE
713947553804
IngredientAmount% DV
Nattokinase NSK-SD100 mg--

Other ingredients: Soybean Oil, Gelatin, Glycerin, Soybean Lecithin, Glycerin Fatty Acid Ester, Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Isolated, purified and encapsulated nattokinase, an enzyme derived from boiled soybeans using a selected, patented strain of Bacillus subtilis natto.

NSK-SD 2000 FU

Formulation

Nattokinase NSK-SD is vegetarian, non-irradiated, and free of vitamin K2.

Nattokinase NSK-SD is vegetarian, non-irradiated, and free of vitamin K2.

Brand IP Statement(s)

NSK-SD is a trademark of Japan BioScience Laboratory.

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, 1 softgel two times daily initial dose, or as directed by a healthcare practitioner. May be taken with or without food. Take with 8 to 10 ounces of water.

Precautions

If taken with anticoagulant drugs, use under medical supervision. Contraindicated in any condition associated with bleeding.

Contains: Soy.

Storage

Keep in a cool, dry place, tightly capped.

General Statements

NutriCology Innovative Nutrition

Product of Japan.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NattoZyme Nattokinase 100 mg by NutriCology label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NattoZyme Nattokinase 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NattoZyme Nattokinase 100 mg by NutriCology

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container180 Amounts shown are per serving.

Nattokinase NSK-SD

Interacts with
289 drugs
100 mg per serving Form: Soy

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase NSK-SD monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Soybean Lecithin, Glycerin Fatty Acid Ester, Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

NattoZyme Nattokinase 100 mg by NutriCology Drug Interactions

Want to check YOUR meds against NattoZyme Nattokinase 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase NSK-SD 289

Individual Drug Interactions

The ingredients in NattoZyme Nattokinase 100 mg interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in NattoZyme Nattokinase 100 mg interact with drugs. Each result below shows which ingredient is responsible. Nattokinase NSK-SD

Each ingredient & the kinds of drugs it affects

For each ingredient in NattoZyme Nattokinase 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase NSK-SD2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase NSK-SD full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NattoZyme Nattokinase 100 mg, from the product label.

NutriCology

See all NutriCology products
Name
NutriCology
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800.545.9960
Web Address
www.nutricology.com
Pharmacist Counseling Corner

NattoZyme Nattokinase 100 mg by NutriCology: Common Questions

Does NattoZyme Nattokinase 100 mg by NutriCology interact with any medications?
Yes. Based on its ingredients, NattoZyme Nattokinase 100 mg has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NattoZyme Nattokinase 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is nattokinase, and where does it come from?
Nattokinase is an enzyme from natto, a traditional Japanese fermented soybean food. It has fibrinolytic properties, meaning it may help break down blood clots. This product uses a standardized form called NSK-SD.
Can I take NattoZyme if I'm taking aspirin?
No — not without checking with your doctor first. Nattokinase has blood-thinning effects, and there's a case report of serious brain bleeding in someone who combined nattokinase with low-dose aspirin. Your healthcare provider needs to weigh the risks for your specific situation.
Does this product work for heart disease or high cholesterol?
The evidence we hold shows insufficient reliable evidence to rate nattokinase for cardiovascular disease, atherosclerosis, or any of the other conditions listed on this product. Talk with your doctor about whether research supports its use for what you're concerned about.
Is it safe to take during pregnancy?
No — there is not enough safety data, so nattokinase is best avoided during pregnancy. If you're pregnant or planning to become pregnant, talk with your doctor or pharmacist about what's right for you.
Can I breastfeed while taking NattoZyme?
Safety is unknown while breastfeeding, so it should be avoided to be safe. Talk with your doctor or pharmacist if you're breastfeeding and want to take any supplement.
Can this product cause allergic reactions?
Yes — people sensitive to natto can have hypersensitivity reactions, including anaphylaxis. Symptoms typically appear within 2 hours and may affect the throat and pharynx. If you've ever had a reaction to fermented soybean foods, talk with your doctor before taking this.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if NattoZyme Nattokinase 100 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NattoZyme Nattokinase 100 mg label
Go deeper

The Full Monographs Behind NattoZyme Nattokinase 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

NattoZyme Nattokinase 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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