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Dietary supplement

Natural Acidophilus 300 mg Ingredients & Drug Interactions

by Rite Aid Pharmacy

Natural Acidophilus 300 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Acidophilus 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Natural Acidophilus 300 mg is a dietary supplement by Rite Aid Pharmacy with 3 active ingredients. Its ingredients are commonly taken for digestive health and regularity, diarrhea (including antibiotic-related), irritable bowel syndrome (ibs) symptoms.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium bifidum, Lactobacillus acidophilus, L. helveticus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natural Acidophilus 300 mg by Rite Aid Pharmacy

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Acidophilus 300 mg by Rite Aid Pharmacy — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Natural Acidophilus 300 mg by Rite Aid Pharmacy

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend (Non-Nutrient/Non-Botanical)” is a proprietary blend — the label gives one combined amount (300 mg) without saying how much of each component you get.

This capsule contains three active probiotic bacteria: Bifidobacterium bifidum, Lactobacillus acidophilus, and L. helveticus, each chosen for their role in supporting gut and immune health. The inactive ingredients are citrus pectin, gelatin, and magnesium stearate — standard capsule components that don't add therapeutic effect but help deliver the probiotics.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: helps maintain a healthy digestive tract.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Inflammatory bowel disease (IBD), Clostridioides difficile infection — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The evidence for what this product can do varies by ingredient and condition. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

Bifidobacterium bifidum is possibly effective for irritable bowel syndrome and respiratory tract infections. L. helveticus, however, shows insufficient evidence for all the conditions studied — allergic rhinitis, antibiotic-associated diarrhea, cognitive function, depression, rotaviral diarrhea, and exercise-induced respiratory infections.

If you're taking this for a specific condition, it's worth discussing with your doctor whether the evidence supports it for your situation.

The evidence, ingredient by ingredient Bifidobacterium Bifidum Lactobacillus Acidophilus Lactobacillus Helveticus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These probiotics are generally well tolerated in healthy adults and children. The most commonly reported side effects are bloating and flatulence, though these haven't been specifically tied to Bifidobacterium bifidum alone.

A single case of vomiting and fever was reported in a child taking B. bifidum with another probiotic, but it's unclear whether the probiotics caused it. There's a theoretical concern that these live organisms could cause serious infection in people with severely weakened immune systems or critical illness — a very rare event — so caution is warranted if you fall into that category.

Because safety data are limited, check with your doctor before use, especially if you're immunocompromised.

Side effects, ingredient by ingredient Bifidobacterium Bifidum Lactobacillus Acidophilus Lactobacillus Helveticus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum, Lactobacillus Helveticus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main concern — all three active ingredients in this product can lose effectiveness if taken at the same time as antibiotics. Space them out by a few hours, with your antibiotic and the probiotic at different times of day.

Check with your doctor or pharmacist about the best timing for your specific antibiotic.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with irritable bowel syndrome, certain infections, or antibiotic-associated diarrhea if you choose the right timing. The key is spacing it away from antibiotics so the drugs don't kill the live organisms.

If you have a weakened immune system or are critically ill, talk with your doctor first. Run your medications through the checker here, and if you're starting an antibiotic, let your pharmacist know you're considering this so they can help you coordinate the timing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Acidophilus 300 mg, straight from the product label.

Brand Rite Aid Pharmacy
Barcode (UPC) 011822880015
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2015
DSLD ID 45292
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Acidophilus 300 mg by Rite Aid Pharmacy, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
011822880015
IngredientAmount% DV
Bifidobacterium bifidum0 NP--
Lactobacillus acidophilus0 NP--
Proprietary Blend (Non-Nutrient/Non-Botanical)300 mg--
L. helveticus0 NP--

Other ingredients: Citrus Pectin, Gelatin, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

FRESHNESS AND POTENCY GUARANTEED THROUGH:

Probiotic Complex

helps maintain a healthy digestive tract*

Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

{Capsule} ACTUAL SIZE

IF YOU'RE NOT SATISFIED, WE'LL HAPPILY REFUND YOUR MONEY.

FDA Statement of Identity

DIETARY SUPPLEMENT

Formulation

- Milk Free

No Artificial Flavors, No Artificial Colors, No Sugar.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

IMPORTANT: Tamper evident seal under cap. Do not use if printed seal is missing or broken.

KEEP OUT OF REACH OF CHILDREN.

General

021309 LNG

Seals/Symbols

RITE AID(R) SATISFACTION GUARANTEED

Suggested/Recommended/Usage/Directions

SUGGESTED USE: As a dietary supplement, take one (1) capsule daily.

Storage

Keep in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Acidophilus 300 mg by Rite Aid Pharmacy label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Acidophilus 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Acidophilus 300 mg by Rite Aid Pharmacy

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend (Non-Nutrient/Non-Botanical)

300 mg per serving

Other (inactive) ingredients: Citrus Pectin, Gelatin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Acidophilus 300 mg by Rite Aid Pharmacy Drug Interactions

Want to check YOUR meds against Natural Acidophilus 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium bifidum 182
Lactobacillus acidophilus 182
L. helveticus 182

Individual Drug Interactions

The ingredients in Natural Acidophilus 300 mg interact with 182 drugs. Click any drug to see the details.

3 of the 3 ingredients in Natural Acidophilus 300 mg interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium bifidum Lactobacillus acidophilus L. helveticus

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Acidophilus 300 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

L. helveticus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus helveticus with antibiotic drugs might decrease the effectiveness of L. helveticus.
Lactobacillus helveticus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. helveticus preparations by at least two hours.

Likelihood Probable Evidence D
L. helveticus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Acidophilus 300 mg, from the product label.

Rite Aid Pharmacy

See all Rite Aid Pharmacy products
Name
Rite Aid
Street Address
30 Hunter Lane
City
Camp Hill
State
PA
ZipCode
17011
Pharmacist Counseling Corner

Natural Acidophilus 300 mg by Rite Aid Pharmacy: Common Questions

Does Natural Acidophilus 300 mg by Rite Aid Pharmacy interact with any medications?
Yes. Based on its ingredients, Natural Acidophilus 300 mg has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Acidophilus 300 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on an antibiotic?
Yes, but not at the same time. Antibiotics can kill the live bacteria in this probiotic, making it less effective. Space them out by several hours — take your antibiotic at one time of day and this product at another. Your pharmacist can help you plan the timing.
What side effects should I watch for?
Bloating and flatulence are the most commonly reported issues with probiotics, though they haven't been specifically reported from Bifidobacterium bifidum alone. A very small number of people taking probiotics have reported gastrointestinal discomfort or rashes, but these are uncommon. If you're immunocompromised or critically ill, there's a rare theoretical risk of infection — check with your doctor first in that case.
Is this safe to take while pregnant or breastfeeding?
Bifidobacterium bifidum and Lactobacillus acidophilus are both rated possibly safe in pregnancy. We don't have safety data on file for L. helveticus in pregnancy or lactation. Because data are limited, talk with your doctor or pharmacist before taking this while pregnant or breastfeeding — they can weigh the benefits for your situation.
Does this actually work for IBS?
Bifidobacterium bifidum and Lactobacillus acidophilus are both possibly effective for irritable bowel syndrome based on the evidence we hold. L. helveticus doesn't have enough reliable evidence yet. If you're considering it for IBS, discuss with your doctor whether it makes sense alongside your current treatment plan.
What is citrus pectin in here?
Citrus pectin is an inactive ingredient — a thickener and binder that helps hold the capsule together. It doesn't contribute to the therapeutic effect of the product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Natural Acidophilus 300 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Acidophilus 300 mg label
Go deeper

The Full Monographs Behind Natural Acidophilus 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Lactobacillus Helveticus

Interacts with 182 drugs

Lactobacillus helveticus is a lactic acid bacterium used as a probiotic, often combined with other strains in mood, gut, and general wellness products. Early research is interesting—especial...

Read the full Lactobacillus Helveticus monograph →
Sources

Sources & How We Checked

Natural Acidophilus 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Lactobacillus Helveticus 2 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

See these in context on the Lactobacillus Helveticus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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