Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Nitro CMX Ingredients & Drug Interactions

by NDS Nutrition Products

Nitro CMX label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nitro CMX against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nitro CMX is a dietary supplement by NDS Nutrition Products with 1 active ingredient. Its ingredients are commonly taken for common cold and immune support, antioxidant support, skin health and collagen formation.Based on those ingredients, 1,371 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin C. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Nitro CMX by NDS Nutrition Products

Ask about any prescription or over-the-counter medication and we check it for interactions with Nitro CMX by NDS Nutrition Products — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Nitro CMX by NDS Nutrition Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 12 active ingredients.
  • “Vitamin C” is listed as a grouped ingredient — the label gives one combined amount (50 mg) without saying how much of each component you get.
  • “NITRO CMX(TM) Blend” is a proprietary blend — the label gives one combined amount (3,007 mg) without saying how much of each component you get.
  • “Performance Antioxidant Blend” is a proprietary blend — the label gives one combined amount (530 mg) without saying how much of each component you get.

Nitro CMX contains 12 ingredients, most of them active. The named active ingredients are resveratrol, vanadyl sulfate, phosphatidylserine, pine bark extract, alpha-lipoic acid, grape seed extract, coenzyme Q10, and beet extract.

The product also includes Vitamin C and several proprietary blends (NITRO CMX Blend, Nitrate Pump Blend, Performance Antioxidant Blend, and Citrulline Complex) whose specific dose breakdown isn't listed. We could not verify the active status or interactions of Arginine AKG and Norvaline because we hold no data for them.

The capsules also contain inactive ingredients: capsule shell, magnesium stearate, microcrystalline cellulose, and silicon dioxide.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: physical conditioning and athletic performance.
  • We looked for evidence on: Athletic performance, exercise recovery, muscle endurance, workout performance.
  • The strongest evidence on file: Beet is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Coenzyme Q10 is rated "Likely Ineffective" for Athletic performance.
  • Also on file: Grape is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

Evidence for this product's ingredients is mixed. Resveratrol is possibly effective for obesity and hay fever (allergic rhinitis), but possibly ineffective for heart disease and high cholesterol.

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease. Pine bark extract is possibly effective for osteoarthritis, poor circulation (chronic venous insufficiency), and asthma.

Alpha-lipoic acid is possibly effective for diabetic nerve damage (neuropathy), high cholesterol, and obesity. Grape seed extract is possibly effective for poor circulation and possibly ineffective for chemotherapy nausea, allergies, and obesity.

Coenzyme Q10 is possibly effective for fibromyalgia, migraines, heart failure, and diabetic neuropathy. Beet extract is possibly effective for athletic performance and exercise soreness.

Vanadium's use for athletic performance, cancer, diabetes, and cholesterol has insufficient evidence. We hold no effectiveness data for the other ingredients.

The evidence, ingredient by ingredient Vitamin C

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated at typical supplement doses. Resveratrol may cause diarrhea, gastrointestinal upset, or loose stools; high doses carry unknown long-term safety.

Vanadium above the safe upper limit (1.8 mg daily) may cause stomach upset, diarrhea, or—at high long-term doses—kidney damage. Phosphatidylserine may cause flatulence, nausea, headache, or insomnia (more likely at 600 mg doses).

Pine bark extract may cause stomach upset, dizziness, or vertigo; long-term safety isn't fully established. Alpha-lipoic acid may cause headache, nausea, heartburn, or rash.

Grape seed extract may cause stomach pain, diarrhea, headache, or nausea. Coenzyme Q10 may cause mild stomach upset, headache, or dizziness (under 1% of users).

Beet extract may cause red or black stools, which is harmless, but large amounts theoretically risk kidney damage. For pregnancy and breastfeeding: resveratrol and grape seed extract should be avoided in concentrated supplement form during pregnancy; vanadium, phosphatidylserine, pine bark, alpha-lipoic acid, and beet extract lack sufficient safety data and should not be used unless your doctor advises.

None of these ingredients have adequate data for breastfeeding—talk to your pharmacist or doctor before use if you're nursing.

Side effects, ingredient by ingredient Vitamin C

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 8 of the 8 matched ingredients can interact with medications — Beet, Resveratrol, Grape, Vanadium, Alpha-lipoic Acid, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 1,352 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Nitro CMX, double-check whether you're on blood thinners or antiplatelet drugs (anticoagulants such as warfarin, apixaban, or aspirin)—several ingredients may increase bleeding risk. If you take diabetes medications, discuss this with your pharmacist, as multiple ingredients may lower blood sugar too far.

Also check if you take cyclosporine (an immunosuppressant), warfarin specifically, midazolam (a sedative), thyroid hormones, chemotherapy drugs, anticholinergic drugs (like those for urinary incontinence or asthma), or cholinergic drugs (like those for myasthenia gravis or Alzheimer disease). The ingredients we could verify interact with many medications; use the search tool below with your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Nitro CMX is a multi-ingredient product designed for athletic performance and circulation. Because it contains ingredients that interact with blood thinners, diabetes drugs, and liver-metabolized medications, and because several ingredients can lower blood sugar or affect blood pressure, you should check your exact medications against the tool below before starting.

Pregnant or breastfeeding women should avoid this product unless a doctor approves it. Talk to your pharmacist if you take any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nitro CMX, straight from the product label.

Brand NDS Nutrition Products
Barcode (UPC) 811020908203
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD May 23, 2014
DSLD ID 33134
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nitro CMX by NDS Nutrition Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
23
UPC/BARCODE
811020908203
IngredientAmount% DV
Vitamin C50 mg83%
Resveratrol0 NP--
Vanadyl Sulfate0 NP--
Phosphatidyl Serine0 NP--
Pine bark extract0 NP--
Alpha Lipoic Acid0 NP--
Grape seed extract0 NP--
Arginine AKG0 NP--
Co-Q-100 NP--
Beet extract0 NP--
Norvaline0 NP--
NITRO CMX(TM) Blend3007 mg--
Nitrate Pump Blend2477 mg--
Performance Antioxidant Blend530 mg--
Citrulline Complex0 NP--

Other ingredients: Capsule Shell, Magnesium Stearate, Microcrystalline Cellulose, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

To be used as part of a physical conditioning program.

Support for Muscle Pumps, Strength, Endurance Vascularity, & Healthy Antioxidants*

FOR SERIOUS ATHLETES ONLY

Arginine AKG Increases Nitric Oxide (N.O.) Levels*

Red Beet Extract Maximizes Nitrate Levels*

NITRIC OXIDE & PERFORMANCE

Suggested/Recommended/Usage/Directions

SUGGESTED USE: Take 3 capsules 60 to 90 minutes before training on an empty stomach to establish tolerance. If less than 200 lbs: 3 casules; If greater than 200 lbs: 4 capsules; If stacking with ACG3(R), Pump Fuel(R) v.2, or Pump Fuel(R) INSANITY: 3 capsules. Alternative option for quicker absorption, break open capsules and add to your pre-workout drink 30 minutes before workout.

Precautions

WARNING: KEEP OUT OF REACH OF CHILDREN.

Do not take if you are currently taking nitrates for chest pain or if you are taking erecile dysfunction medication. Do not take if you are pregnant or nursing.

This product is only intended to be consumed by healthy adults 18 years of age or older.

Use this product with caution if you have a history of cold sores. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Do not use if tamper resistant seal is broken.

Before using this product consult with your physician if you are using any prescription or over the counter medication or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAOI (Monoamine Oxidase Inhibitor) or any other medication.

Storage

STORE IN A COOL, DRY PLACE AND AVOID EXCESSIVE HEAT.

Seals/Symbols

78 PMD PLATINUM 78(R)

NX Nitrate Xpanders N.O. Nitrate Catalyst*

Brand IP Statement(s)

PMD(R)PLATINUM

FDA Statement of Identity

STIMULANT AND CREATINE FREE DIETARY SUPPLEMENT

Formulation

STIMULANT AND CREATINE FREE DIETARY SUPPLEMENT

GLUTEN FREE

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

-1

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See for yourself

Nitro CMX by NDS Nutrition Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nitro CMX label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nitro CMX by NDS Nutrition Products

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container23 Amounts shown are per serving.

Vitamin C

Interacts with
207 drugs
50 mg per serving Form: Ascorbic Acid

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions
  • › NITRO CMX(TM) Blend
  • › Performance Antioxidant Blend

Other (inactive) ingredients: Capsule Shell, Magnesium Stearate, Microcrystalline Cellulose, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nitro CMX by NDS Nutrition Products Drug Interactions

Want to check YOUR meds against Nitro CMX?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,371Drugs
1,223 Moderate 148 Minor

Ingredients driving the most interactions

Vitamin C 207

Individual Drug Interactions

The ingredients in Nitro CMX interact with 1,371 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nitro CMX interact with drugs. Each result below shows which ingredient is responsible. Vitamin C

Each ingredient & the kinds of drugs it affects

For each ingredient in Nitro CMX with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Vitamin C full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nitro CMX, from the product label.

NDS Nutrition Products

See all NDS Nutrition Products products
Name
NDS Nutrition Products, Inc. A Division of Bond Laboratories, Inc.
Street Address
4509 S. 143rd St., Ste. 1
City
Omaha
State
NE
ZipCode
68137
Web Address
www.ndsnutrition.com
Pharmacist Counseling Corner

Nitro CMX by NDS Nutrition Products: Common Questions

Does Nitro CMX by NDS Nutrition Products interact with any medications?
Yes. Based on its ingredients, Nitro CMX has a known interaction with 1,371 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nitro CMX contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take Nitro CMX if I'm pregnant or breastfeeding?
No, most ingredients lack sufficient safety data for pregnancy or breastfeeding. Resveratrol and grape seed extract should be avoided in concentrated supplement form during pregnancy. Vanadium, phosphatidylserine, pine bark extract, alpha-lipoic acid, and beet extract all carry warnings to avoid unless your doctor says otherwise. Talk to your doctor or pharmacist before use if you're pregnant or nursing.
Will Nitro CMX cause digestive upset?
Possibly. Several ingredients can cause stomach discomfort, diarrhea, nausea, or flatulence—especially resveratrol, vanadium at higher doses, phosphatidylserine, alpha-lipoic acid, and grape seed extract. Beet extract may cause red or black stools, which is harmless.
What does each ingredient in Nitro CMX do?
Resveratrol is studied for obesity and hay fever. Vanadium supports normal glucose metabolism. Phosphatidylserine may help with age-related cognitive decline. Pine bark extract is used for joint health and circulation. Alpha-lipoic acid is possibly effective for diabetic nerve damage and cholesterol. Grape seed extract supports circulation. Coenzyme Q10 is used for heart health and migraines. Beet extract supports athletic performance.
Can Nitro CMX lower my blood sugar or blood pressure?
Yes. Several ingredients—vanadium, pine bark extract, alpha-lipoic acid, and beet extract—may lower blood sugar or blood pressure. If you take diabetes or blood pressure medications, check with your pharmacist first, as this product could cause unsafe drops in either level.
Does Nitro CMX interact with my blood thinner or aspirin?
Possibly. Resveratrol, vanadyl sulfate, pine bark extract, alpha-lipoic acid, and grape seed extract all have antiplatelet effects and theoretically may increase bleeding risk if you're on a blood thinner or antiplatelet drug. Check your specific medications with the tool below before starting.
What are the most common side effects?
Diarrhea, nausea, headache, and stomach upset are most frequently reported across the ingredients. Resveratrol may cause loose stools; alpha-lipoic acid may cause headache or nausea; grape seed extract may cause diarrhea or headache; and beet extract may turn your stools red—which is not harmful.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nitro CMX label
Go deeper

The Full Monographs Behind Nitro CMX’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph →
Sources

Sources & How We Checked

Nitro CMX's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 249 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin C 51 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  3. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
  4. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  5. Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevent
  6. Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. PubMed
  7. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  8. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  9. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  10. Houston JB, Levy G. Drug biotransformation interactions in man VI: Acetaminophen and ascorbic acid. J Pharm Sci 1976;65:1218-21. PubMed
  11. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  12. Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
  13. Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
  14. Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
  15. Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol 2003;170:397-401.. PubMed
  16. Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminum absorption (letter). Lancet 1991;338:1467.
  17. Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. PubMed
  18. Partridge NA, Regnier FE, White JL, Hem SL. Influence of dietary constituents on intestinal absorption of aluminum. Kidney Int 1989;35:1413-7. PubMed
  19. Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. DOI
  20. Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. PubMed
  21. Dysken MW, Cumming RJ, Channon RA, Davis JM. Drug interaction between ascorbic acid and fluphenazine. JAMA 1979;241:2008. DOI
  22. Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
  23. Slain D, Amsden JR, Khakoo RA, et al. Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Pharmacotherapy 2005;25:165-70. PubMed
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See these in context on the Alpha-lipoic Acid monograph →

Grape 34 references
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See these in context on the Grape monograph →

Coenzyme Q10 40 references
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Beet 14 references
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  11. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
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See these in context on the Beet monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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