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Dietary supplement

NKC Immune Boost Ingredients & Drug Interactions

by Sylvan Bio

NKC Immune Boost label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NKC Immune Boost against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

NKC Immune Boost is a dietary supplement by Sylvan Bio with 2 active ingredients. Its ingredients are commonly taken for immune support, general wellness and antioxidant, adjunct interest during cancer care.Based on those ingredients, 795 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D, Agaricus blazei. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against NKC Immune Boost by Sylvan Bio

Ask about any prescription or over-the-counter medication and we check it for interactions with NKC Immune Boost by Sylvan Bio — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of NKC Immune Boost by Sylvan Bio

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

NKC Immune Boost contains two active ingredients: agaricus mushroom (also called Agaricus blazei) and vitamin D. The product also includes inactive ingredients—the mushroom powder itself and gelatin capsules.

Agaricus mushroom is a medicinal fungus, and vitamin D is a fat-soluble vitamin your body needs for calcium absorption and immune function. Both are included to support immune health, though the evidence for agaricus mushroom's specific benefits is still being established.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: immune system support.
  • We looked for evidence on: HIV/AIDS, Pneumonia, immune function, Natural Killer Cell activity, infection resistance.
  • The closest evidence on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for HIV/AIDS (Natural Medicines).
  • Also on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Pneumonia.

Vitamin D is effective for treating rickets, osteomalacia (soft bones), renal bone disease, familial hypophosphatemia, and hypoparathyroidism. For agaricus mushroom, the evidence isn't yet established in our data.

Clinical trials have looked at its potential role in hay fever, osteoporosis, cancer, heart disease, chemotherapy side effects, and Crohn's disease, but none of these uses have sufficient reliable evidence to rate as proven.

The evidence, ingredient by ingredient Agaricus Mushroom Vitamin D

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally well tolerated at recommended doses, but very high doses over time can cause toxicity with symptoms of high calcium levels (hypercalcemia). Agaricus mushroom is generally well tolerated as a food, though the safety and long-term effects of supplement doses aren't well established.

The most common side effects from agaricus mushroom are abdominal discomfort, diarrhea, and nausea. Rare but serious side effects include allergic reactions, liver damage, and lung inflammation (interstitial lung disease).

Three cases of severe liver damage have been reported in women with ovarian or breast cancer receiving chemotherapy who also took agaricus mushroom. For pregnancy: vitamin D is likely safe at recommended amounts, though you should use it only under your doctor's guidance.

Agaricus mushroom has insufficient safety data, so it's best to avoid supplement doses during pregnancy. For breastfeeding: vitamin D is generally considered acceptable at recommended doses, but check with your doctor before taking higher amounts.

Agaricus mushroom also lacks sufficient safety data for breastfeeding, so avoid it during this time.

Side effects, ingredient by ingredient Agaricus Mushroom Vitamin D

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin D, Agaricus Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications.
  • For scale: 796 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood sugar medications (agaricus mushroom may increase low blood sugar risk), heart rhythm medications like verapamil, diltiazem, or digoxin (vitamin D can interfere with how well they work or raise calcium dangerously), thiazide diuretics or water pills (vitamin D may raise calcium too high), cholesterol drugs like atorvastatin (vitamin D may reduce absorption), or calcipotriene for psoriasis (combined use increases calcium risk). Vitamin D may also affect how your body breaks down many other medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines a mushroom with potential immune benefits (though the evidence is still being studied) with vitamin D, which has proven roles in bone and mineral health. If you take any medications—especially blood sugar drugs, heart medications, cholesterol drugs, or water pills—check your exact list with the search tool on this page before starting.

Talk it over with your doctor or pharmacist to make sure it's right for you and won't interfere with your other treatments.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NKC Immune Boost, straight from the product label.

Brand Sylvan Bio
Barcode (UPC) 813892006018
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 249769
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NKC Immune Boost by Sylvan Bio, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
813892006018
IngredientAmount% DV
Agaricus blazei1000 mg--
Vitamin D1000 IU125%

Other ingredients: organic Agaricus blazei Mushrooms, Gelatin Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

NKC Immune Boost contains powdered Agaricus blazei mushrooms (ABM) naturally enhanced with vitamin D. ABM stimulates the body's immune system by triggering an increase in the production of Natural Killer Cells (NKC). These cells are the body's first line of defense against infection by working to recognize and destroy viruses and other microbes. The vitamin D in NKC immune boost has been demonstrated to support the body's natural defense against infection. With the unique combination of bioactive compounds in agaricus blazei, NKC immune boost assists the body in building and maintaining a strong immune system.

Organic agaricus blazei mushroom powder

General Statements

Find out more at www.sylvanwellness.com

Sylvan Bio Sylvan Wellness

Suggested/Recommended/Usage/Directions

Directions for use: Take 2 capsules 2 times per day (morning and evening) with water at mealtimes. Do not take more than 4 capsules in a 24 hour period.

Precautions

Keep out of reach of children.

As with any dietary supplement, consult a physician if you are taking any prescription.

Warning: Do not use if you are pregnant, can become pregnant, or are nursing; have undergone an organ transplant or major surgery within the past six weeks; have active liver disease or history of liver disease; are allergic to mushrooms or mushroom products.

Warning: Do not use if you are pregnant, can become pregnant, or are nursing; have undergone an organ transplant or major surgery within the past six weeks; have active liver disease or history of liver disease; are allergic to mushrooms or mushroom products.

Do not use if freshness seals are damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cur or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formulation

The natural way to enhance immune function

Produced and bottled in the USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NKC Immune Boost by Sylvan Bio label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NKC Immune Boost label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NKC Immune Boost by Sylvan Bio

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Agaricus blazei

Interacts with
86 drugs
1000 mg per serving

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects...

Agaricus blazei monograph & interactions

Vitamin D

Interacts with
715 drugs
1000 IU per serving Form: Ergocalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Other (inactive) ingredients: Organic Agaricus blazei Mushrooms, Gelatin Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

NKC Immune Boost by Sylvan Bio Drug Interactions

Want to check YOUR meds against NKC Immune Boost?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
795Drugs
166 Moderate 629 Minor

Ingredients driving the most interactions

Vitamin D 715
Agaricus blazei 86

Individual Drug Interactions

The ingredients in NKC Immune Boost interact with 795 drugs. Click any drug to see the details.

2 of the 2 ingredients in NKC Immune Boost interact with drugs. Each result below shows which ingredient is responsible. Vitamin D Agaricus blazei

Each ingredient & the kinds of drugs it affects

For each ingredient in NKC Immune Boost with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D full monograph & interactions

Agaricus blazei1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
Agaricus blazei full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NKC Immune Boost, from the product label.

Sylvan Bio

See all Sylvan Bio products
Name
Sylvan Bio, Inc.
Street Address
198 Nolte Drive
City
Kittanning
State
PA
ZipCode
16201
Phone Number
1-866-352-7520
Pharmacist Counseling Corner

NKC Immune Boost by Sylvan Bio: Common Questions

Does NKC Immune Boost by Sylvan Bio interact with any medications?
Yes. Based on its ingredients, NKC Immune Boost has a known interaction with 795 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NKC Immune Boost contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is agaricus mushroom, and why is it in this product?
Agaricus blazei is a medicinal mushroom included for potential immune support. However, the evidence for its specific immune benefits isn't yet established in our data. It's been studied for hay fever, osteoporosis, cancer, and other conditions, but none of these uses have sufficient reliable evidence to rate as proven yet.
Can I take this if I'm pregnant or breastfeeding?
Vitamin D is likely safe at recommended doses during pregnancy, but use it only under your doctor's guidance. Agaricus mushroom has insufficient safety data—it's best to avoid it during pregnancy. For breastfeeding, vitamin D is generally acceptable at recommended doses if you check with your doctor first, but agaricus mushroom lacks safety data, so you should avoid it while breastfeeding.
What side effects might I get from agaricus mushroom?
Most commonly, abdominal discomfort, diarrhea, and nausea. Rare but serious side effects include allergic reactions, liver damage, and lung inflammation. Three cases of severe liver damage have been reported in women with cancer on chemotherapy who also took agaricus mushroom supplements.
Is vitamin D safe to take long-term?
Vitamin D is well tolerated at recommended doses. However, very high doses over time can cause toxicity, with symptoms of high calcium levels. This is why it's important not to exceed recommended doses without medical guidance.
Can high-dose vitamin D cause problems?
Yes. Very high doses can lead to vitamin D toxicity, causing high calcium levels (hypercalcemia), bone loss, and in children, slowed growth. High-dose vitamin D also increases the risk of dangerous interactions with heart medications, water pills, and calcium-raising drugs, which is why you should check your medications before taking this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NKC Immune Boost label
Go deeper

The Full Monographs Behind NKC Immune Boost’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph → Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph →
Sources

Sources & How We Checked

NKC Immune Boost's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

See these in context on the Agaricus Mushroom monograph →

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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