Major interaction on record — check this product against your medications before combining. Based on 7 of 9 ingredients. Check your meds →
Dietary supplement

NO2 Black Muscle+Pump Jacked Juice Ingredients & Drug Interactions

by MRI Performance

NO2 Black Muscle+Pump Jacked Juice label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NO2 Black Muscle+Pump Jacked Juice against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

NO2 Black Muscle+Pump Jacked Juice is a dietary supplement by MRI Performance with 9 active ingredients. Its ingredients are commonly taken for common cold and immune support, antioxidant support, skin health and collagen formation.Based on those ingredients, 2,219 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Activated Charcoal, Agmatine Sulfate, Vitamin C. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against NO2 Black Muscle+Pump Jacked Juice by MRI Performance

Ask about any prescription or over-the-counter medication and we check it for interactions with NO2 Black Muscle+Pump Jacked Juice by MRI Performance — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of NO2 Black Muscle+Pump Jacked Juice by MRI Performance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 8 of its 15 active ingredients.
  • “Detox Agent” is listed as a grouped ingredient — the label gives one combined amount (200 mg) without saying how much of each component you get.
  • “Pump & Feed Formula” is a proprietary blend — the label gives one combined amount (15,700 mg) without saying how much of each component you get.
  • “S7 N1284” is listed as a grouped ingredient — the label gives one combined amount (200 mg) without saying how much of each component you get.

NO2 Black Muscle+Pump Jacked Juice contains 15 active ingredients designed to support blood flow and athletic performance. The cornerstones are L-Citrulline (converted to nitric oxide to open blood vessels), Agmatine Sulfate, and Ornithine Hydrochloride — amino acids meant to enhance muscle pump and circulation.

Green Tea extract, Green Coffee Bean extract, and Vitamin C provide antioxidant support; Turmeric extract adds anti-inflammatory compounds. Plant-based nutrients include Kale, Broccoli, Blueberry, and Tart Cherry for micronutrients and phytonutrients.

The formula also includes Activated Charcoal and glycerol (HydroMax) for hydration and detoxification support, plus Sodium for electrolyte balance. Three ingredients — Nitrosigine, a Detox Agent blend, and a Pump & Feed Formula — are either not fully detailed in our data or are proprietary blends.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle pump, vascularity, and athletic performance.
  • We looked for evidence on: Athletic performance, Muscle growth, Blood flow and vasodilation, Endurance and stamina, Nutrient delivery.
  • The strongest evidence on file: Glycerol is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Ornithine is rated "Possibly Effective" for Athletic performance.
  • Also on file: Sour Cherry is rated "Possibly Effective" for Athletic performance.

Evidence for this product's active ingredients is mixed. L-Citrulline is possibly effective for athletic performance, though long-term safety isn't fully studied.

Green Tea extract is possibly effective for lowering cholesterol and may help with certain cancers, but most other claimed benefits lack strong evidence. Green Coffee Bean extract shows possibly effective evidence for mental alertness and may support heart health and blood sugar.

Vitamin C is effective for preventing deficiency and possibly helpful for exercise-related infections. Tart Cherry is possibly effective for athletic performance and exercise recovery.

Agmatine, Ornithine, Turmeric, Broccoli, Blueberry, Kale, and Activated Charcoal all show insufficient reliable evidence for most claims made about them, though Turmeric is possibly effective for depression and digestive upset. The pump and performance benefits you're likely buying this for aren't backed by strong data for most of these ingredients together.

The evidence, ingredient by ingredient Vitamin C Sodium Activated Charcoal L-citrulline Agmatine Ornithine Glycerol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 12 of the 14 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 14 of 14.
  • General safety write-ups exist for 14 of 14.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients here are generally well tolerated in food amounts, but this is a supplement with multiple concentrated actives. L-Citrulline commonly causes gastrointestinal discomfort and heartburn; Vitamin C at high doses can cause diarrhea, kidney stones, and abdominal cramps — adverse effects are more likely above 2 grams daily.

Green Tea extract, especially in concentrated form, has been linked to rare liver injury. Activated Charcoal causes constipation and black stools commonly; more rarely it can cause bowel obstruction.

Turmeric has been associated with at least 70 reports of liver damage with supplement use lasting 2+ weeks. Agmatine's long-term safety in humans is not well studied.

Sodium in high amounts increases cardiovascular and kidney strain. Green Coffee Bean extract (caffeine) can cause anxiety, insomnia, and heart palpitations — more so in sensitive individuals.

Blueberry and Tart Cherry may cause gastrointestinal upset, particularly at high doses. Pregnancy: L-Citrulline, Agmatine, and Ornithine lack sufficient safety data and should be avoided.

Vitamin C at normal food amounts is fine, but high-dose supplements should be avoided unless your doctor approves. Sodium is likely safe at usual intake.

Kale, Broccoli, Blueberry, and Tart Cherry as foods are safe; concentrated forms are less studied. Breastfeeding: Caffeine in Green Coffee Bean extract passes into breast milk — keep intake moderate and watch your baby for fussiness or sleep problems.

Side effects, ingredient by ingredient Vitamin C Sodium Activated Charcoal L-citrulline Agmatine Ornithine Glycerol

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 10 of the 14 matched ingredients can interact with medications — Activated Charcoal, Turmeric, Green Tea, Coffee, Vitamin C, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications; lithium.
  • For scale: 2,220 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist or doctor if you're on any of these: heart and blood pressure medications (L-Citrulline, Sodium, Agmatine may lower BP dangerously; Green Tea may make some ineffective); blood thinners like warfarin (Vitamin C may reduce effectiveness); erectile dysfunction drugs like sildenafil (L-Citrulline adds risk of low blood pressure); seizure medications (Green Tea and Broccoli may reduce effectiveness); diabetes drugs (Blueberry and Agmatine may increase low-blood-sugar risk); anticancer drugs, especially chemotherapy agents (Vitamin C, Turmeric, and Green Tea may interfere); mood medications like SSRIs and antipsychotics (Green Coffee Bean may increase side effects); lithium for bipolar disorder (Sodium can raise lithium levels dangerously); oral contraceptives (Vitamin C may increase estrogen levels); and any oral medication in general (Activated Charcoal can reduce absorption of many drugs). If you take multiple medications, the checklist below is non-negotiable.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product packs strong ingredients for workout support and blood flow, but it comes with real medication interactions and concentration-related safety concerns. If you take any prescription drugs — especially for heart, blood pressure, diabetes, seizures, mood, cancer, or blood thinning — you must check your medications against the tool below before starting.

Even if you're medication-free, the combination of caffeine, high sodium, and concentrated plant extracts means side effects like stomach upset, jitters, or (rarely) liver stress are possible. Talk to your pharmacist or doctor before using, especially if you have liver or kidney disease, are pregnant or breastfeeding, or are sensitive to caffeine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 14 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NO2 Black Muscle+Pump Jacked Juice, straight from the product label.

Brand MRI Performance
Barcode (UPC) 850008777059
Net contents 1.3 lbs; 588 Gram(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 251087
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NO2 Black Muscle+Pump Jacked Juice by MRI Performance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
9.8 Gram(s), 19.6 Gram(s)
Maximum serving Sizes:
9.8 Gram(s), 19.6 Gram(s)
Servings per container
30
UPC/BARCODE
850008777059
IngredientAmount% DV
L-Citrulline8000 mg--
Vitamin C250 mg278%
Green Tea extract0 NP--
Sodium80 mg3%
Kale0 NP--
Broccoli0 NP--
Blueberry0 NP--
Agmatine Sulfate1000 mg--
Activated Charcoal200 mg--
Tart Cherry0 NP--
Turmeric extract0 NP--
Ornithine Hydrochloride1500 mg--
Green Coffee bean extract0 NP--
Detox Agent200 mg--
HydroMax3000 mg--
Nitrosigine2000 mg--
Pump & Feed Formula15700 mg--
S7 N1284200 mg--

Other ingredients: Natural & Artificial flavors, Silicon Dioxide, Citric Acid, Sucralose, Malic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Back in Black

Based on a double blind study, S7 was clinically shown to increase NO levels in humans by 230%. Compared to Original NO2 Black.

Pump & Power

Servings Per Container: 60 30

Formulation

500% more nitric oxide ingredients & 230% more nitric oxide than our original NO2 Black

Promotes hyper pumps, extreme vascularity and muscle growth

Free from: egg, fish, crustacean shellfish, tree nuts, wheat, peanuts, soybeans, yeast, artificial colors, added sugar or preservatives.

Stimulant-free Stimulants can constrict the blood vessels. Having stimulants in a NO product can be counter-productive. MRI's NO2 Black Muscle+Pump is stimulant-free so you can optimize pumps without interference.

Formula

Power through your training with hyper pump, energy and vascularity, NO2 Black Muscle+Pump is packed with S7, Nitrosigine, and HydroMax to help boost NO production, hydration and dilation to promote increased power and pumps during your workouts.

Nitric Oxide helps open up blood vessels and expand muscle delivery systems while you train. When blood flow to the body is increased, so is nutrient delivery. The result is the ideal environment to support building muscle while you increase performance, power and pumps. Welcome to the Pump & Feed Philosophy.

500% More nitric oxide ingredients for bigger pumps

Jacked Juice Natural and Artificial flavors

Pump & Power Nitrosignine supports increased blood flow and enhanced pumps so you can power through workouts with extended energy and stamina. Citrulline converts arginine to Nitric Oxide (NO) to help increase your pump. Agmatine sulfate helps prevent NO breakdown so you can enhance your training time to improve endurance. Added minerals help your muscles contract so you can build your body the way you want. S7 supports increased NO production, and helps widen blood vessels by as much as 50% for extreme vascularity and endurance. Hyper hydration & stamina HydroMax helps hydrate your muscles to support longer workouts and increased muscle pump and fullness. L-Orthinine breaks down fatigue-promoting metabolites and promotes longer and harder training.

Suggested/Recommended/Usage/Directions

Directions and Suggested Use: 1 serving (1 scoop) twice a day. On training days, adhere to the serving chart below.

On training days take your first serving with 4-6 oz of water on an empty stomach 0-30 minutes before a workout. Consume your second serving at least 6 hours before or after your pre-workout serving. Adjust water amount to desired consistency. As NO2 Black Muscle+Pump is highly concentrated, adhere to the below serving chart.

Daily Serving Chart Up to 200 Pounds 1 Serving 1 serving (1 scoop) at least 30 minutes before eating or working out

Over 200 Pounds 2 Servings 2 servings (2 scoops) at least 30 minutes before eating or working out

Note: To maximize results, drink at least 64 ounces of water daily while using NO2 Black Muscle+Pump.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Keep out of the reach of children.

Warning: Do not exceed recommended dose listed.

This product is not intended for use by any persons under age 18, who are pregnant or lactating, or have serious medical conditions including high blood pressure and a history of cold sores, are taking prescription drugs, or have allergies to arginine, corn, or citrus fruit.

This product is not intended for use by any persons under age 18, who are pregnant or lactating, or have serious medical conditions including high blood pressure and a history of cold sores, are taking prescription drugs, or have allergies to arginine, corn, or citrus fruit.

This product is not intended for use by any persons under age 18, who are pregnant or lactating, or have serious medical conditions including high blood pressure and a history of cold sores, are taking prescription drugs, or have allergies to arginine, corn, or citrus fruit.

All persons should consult a physician or your healthcare professional before using dietary supplements, as individuals may have different supplemental needs. Consumption of this product that is inconsistent with recommended usage may produce adverse side effects. Discontinue use and contact a physician immediately if you experience any adverse symptoms. Discontinue use two weeks prior to surgery.

Storage

Keep container tightly closed in a cool, dry and dark place.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Hydromax is a registered trademark of Glanbia PLC. Hydromax glycerol powder 65%

S7 is a trademark of VDF FutureCeuticals, Inc., used under license. Nitrosigine, including the Nitrosigine logo, is a registered trademark of Nutrition 21, LLC. Nitrosigine is patent protected. Nitrosigine bonded arginine silicate

Copyright 2019, Medical Research Institute

Seals/Symbols

Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NO2 Black Muscle+Pump Jacked Juice by MRI Performance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NO2 Black Muscle+Pump Jacked Juice label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NO2 Black Muscle+Pump Jacked Juice by MRI Performance

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size9.8 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin C

Interacts with
207 drugs
250 mg per serving Form: Ascorbic Acid

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

Sodium

Interacts with
205 drugs
80 mg per serving Form: Sodium Chloride

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Detox Agent

200 mg per serving

Pump & Feed Formula

15700 mg per serving

Other (inactive) ingredients: Natural & Artificial flavors, Silicon Dioxide, Citric Acid, Sucralose, Malic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

NO2 Black Muscle+Pump Jacked Juice by MRI Performance Drug Interactions

Want to check YOUR meds against NO2 Black Muscle+Pump Jacked Juice?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,219Drugs
2,022 Major 195 Moderate 2 Minor

Ingredients driving the most interactions

Activated Charcoal 2,027
Agmatine Sulfate 258
Vitamin C 207
Sodium 205
L-Citrulline 178

Individual Drug Interactions

The ingredients in NO2 Black Muscle+Pump Jacked Juice interact with 2,219 drugs. Click any drug to see the details.

5 of the 9 ingredients in NO2 Black Muscle+Pump Jacked Juice interact with drugs. Each result below shows which ingredient is responsible. Activated Charcoal Agmatine Sulfate Vitamin C Sodium L-Citrulline

Each ingredient & the kinds of drugs it affects

For each ingredient in NO2 Black Muscle+Pump Jacked Juice with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Activated Charcoal3 drug types · 2,027 drugs

Oral Drugs

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Activated charcoal adsorbs various drugs and may reduce their absorption and/or half-life. Examples of affected drugs include acetaminophen, aminophylline, amiodarone, atenolol, carbamazepine, dapsone, digoxin, disopyramide, fluoxetine, indomethacin, moxifloxacin, nadolol, phenytoin, phenobarbital, piroxicam, quinine, sotalol, theophylline, tricyclic antidepressants, valproate, and verapamil. Avoid co-administration, except after drug overdose.

Likelihood Probable Evidence B
Alcohol (Ethanol)

The binding action of activated charcoal may be reduced by alcohol.
Alcohol may lower the adsorptive capacity of activated charcoal.

Likelihood Probable Evidence D
Contraceptive Drugs

Activated charcoal may reduce the clinical effects of oral contraceptives.
Activated charcoal, taken in a dose of 5 grams four times daily for 3 days, may bind to, and reduce the absorption of, oral contraceptives, thereby limiting their effectiveness and increasing the risk of contraceptive failure. However, some clinical research shows that the risk for this interaction is minimal when activated charcoal is taken either 3 hours after or at least 12 hours before oral contraceptives.

Likelihood Possible Evidence B
Activated Charcoal full monograph & interactions

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Vitamin C full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NO2 Black Muscle+Pump Jacked Juice, from the product label.

MRI Performance

See all MRI Performance products
Name
MRI Medical Research Institute
Street Address
PO Box 18215
City
Fairfield
State
OH
ZipCode
45018
Phone Number
1-888-922-5567
Web Address
www.mri-performance.com
Pharmacist Counseling Corner

NO2 Black Muscle+Pump Jacked Juice by MRI Performance: Common Questions

Does NO2 Black Muscle+Pump Jacked Juice by MRI Performance interact with any medications?
Yes. Based on its ingredients, NO2 Black Muscle+Pump Jacked Juice has a known interaction with 2,219 medications, including 2022 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NO2 Black Muscle+Pump Jacked Juice contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me get a better pump during my workout?
L-Citrulline, the main ingredient, is possibly effective for athletic performance and works by boosting nitric oxide to increase blood flow — that's the mechanism behind a pump. But the evidence isn't rock-solid, and results vary person to person. Agmatine and Ornithine are added for the same reason, though data on them is limited. Combined with hydration from the glycerol, you may see better vascularity, but don't expect miracles.
Is it safe to take this every day?
Short-term daily use is generally okay for healthy adults without medication conflicts, but several ingredients — especially L-Citrulline and Turmeric — haven't been studied long-term. Activated Charcoal daily can cause constipation. The caffeine from Green Coffee Bean adds up over time. If you're thinking daily, talk to your pharmacist first, especially if you have liver or kidney problems.
Can I take this if I'm on blood pressure medication?
No, not without checking with your doctor first. L-Citrulline, Sodium, and Agmatine can all theoretically lower blood pressure, and Green Tea extract may make certain blood pressure drugs less effective. The combination could drop your pressure dangerously or reduce your medication's benefit. This is one you absolutely must run by your pharmacist before starting.
What's the activated charcoal in here for?
Activated Charcoal is marketed as a detoxifier, but it's mainly known for binding toxins in poisoning cases. In this product it's likely added as a detox ingredient, though the evidence for its benefit in a sports drink is weak. The bigger issue: it can bind and reduce absorption of oral medications — another reason to space doses apart if you take other drugs.
Will this upset my stomach?
Yes, possibly. L-Citrulline commonly causes gastrointestinal discomfort and heartburn. Vitamin C at the levels here can cause cramps and diarrhea. Blueberry and Tart Cherry may cause GI upset, especially in sensitive people. Activated Charcoal causes constipation. Start with a smaller dose and take it with food to test your tolerance.
Is this safe during pregnancy or while breastfeeding?
No. L-Citrulline, Agmatine, and Ornithine lack enough safety data — best to avoid them. Vitamin C at high-dose supplement levels should also be avoided unless your doctor says okay. The caffeine from Green Coffee Bean passes into breast milk and can make your baby fussy or cause sleep problems. Talk to your OB or midwife before using any of this product during pregnancy or nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NO2 Black Muscle+Pump Jacked Juice label
Go deeper

The Full Monographs Behind NO2 Black Muscle+Pump Jacked Juice’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Activated Charcoal

Interacts with 2,027 drugs

Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some poisonings and overdoses. For everyday uses like g...

Read the full Activated Charcoal monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph → Herb & supplement monograph

Ornithine

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep,...

Read the full Ornithine monograph → Herb & supplement monograph

Glycerol

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...

Read the full Glycerol monograph →
Sources

Sources & How We Checked

NO2 Black Muscle+Pump Jacked Juice's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 637 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
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  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Vitamin C 51 references
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  33. Gruenwald, J., Graubaum, H. J., Busch, R., and Bentley, C. Safety and tolerance of ester-C compared with regular ascorbic acid. Adv.Ther. 2006;23(1):171-178.
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  35. Einerson, B., Nathorn, C., Kitiyakara, C., Sirada, M., and Thamlikitkul, V. The efficacy of ascorbic acid in suboptimal responsive anemic hemodialysis patients receiving erythropoietin: a meta-analysis. J Med.Assoc.Thai. 2011;94 Suppl 1:S134-S146.
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  37. Chen X, Shen L, Gu X, et al. High-dose supplementation with vitamin C--induced pediatric urolithiasis: the first case report in a child and literature review. Urology. 2014;84(4):922-4. PubMed
  38. Sattar A, Willman JE, Kolluri R. Possible warfarin resistance due to interaction with ascorbic acid: case report and literature review. Am J Health Syst Pharm. 2013;70(9):782-6. PubMed
  39. Yaich S, Chaabouni Y, Charfeddine K, et al. Secondary oxalosis due to excess vitamin C intake: a cause of graft loss in a renal transplant recipient. Saudi J Kidney Dis Transpl. 2014;25(1):113-6. PubMed
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  42. Seo MS, Kim JK, Shim JY. High-dose vitamin C promotes regression of multiple pulmonary metastases originating from hepatocellular carcinoma. Yonsei Med J. 2015;56(5):1449-52. PubMed
  43. Skelin M, Lucijanic T, Amidzic Klaric D, et al. Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review. Clin Ther. 2017 Feb;39(2):378-403. PubMed
  44. Jiang K, Tang K, Liu H, Xu H, Ye Z, Chen Z. Ascorbic acid supplements and kidney stones incidence among men and women: a systematic review and meta-analysis. Urol J. 2019;16(2):115-120.
  45. Thomas S, Patel D, Bittel B, et al. Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. JAMA Netw Open. 2 PubMed
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See these in context on the Vitamin C monograph →

Green Tea 219 references
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Kale 2 references
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Broccoli 5 references
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Agmatine 3 references
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See these in context on the Turmeric monograph →

Ornithine 1 reference
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Ornithine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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