NOXygen Unflavored Ingredients & Drug Interactions
by Purus
What is this page for?
First and foremost: checking NOXygen Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
NOXygen Unflavored is a dietary supplement by Purus with 4 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 205 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against NOXygen Unflavored by Purus
Ask about any prescription or over-the-counter medication and we check it for interactions with NOXygen Unflavored by Purus — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of NOXygen Unflavored by Purus
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
NOXygen Unflavored contains four active ingredients: sodium, NO3-T, Hydromax, and NOXygen Blend. The product also includes inactive ingredients (silica, calcium silicate, and natural flavors) that serve as fillers and binders.
We have effectiveness ratings for sodium alone — it's rated Likely Effective for cystic fibrosis and Possibly Effective for amphotericin B nephrotoxicity. We don't hold effectiveness data for NO3-T, Hydromax, or the NOXygen Blend.
Does it work?
Couldn't assess
Sodium in this product is rated Likely Effective for cystic fibrosis and Possibly Effective for reducing kidney damage from amphotericin B treatment. For other uses like bipolar disorder or congestive heart failure, the evidence we have is insufficient to rate it.
We don't hold effectiveness ratings for the other three active ingredients (NO3-T, Hydromax, and NOXygen Blend), so we can't comment on what those contribute to the product's purpose.
How safe is it?
Well-documented data
Sodium is well tolerated at normal dietary amounts — up to about 2.3 grams daily, the recommended limit. Too much sodium is linked to high blood pressure, heart strain, and kidney problems.
Rare serious side effects from excess sodium include worsened cardiovascular disease, high blood pressure, and kidney damage. Population studies also suggest very high sodium intake is tied to increased gastric cancer risk.
For pregnancy and breastfeeding, sodium is rated Likely Safe, but also Possibly Unsafe — the data is mixed. Talk with your doctor or pharmacist before taking a sodium supplement if you're pregnant or breastfeeding.
We don't hold safety data for NO3-T or Hydromax.
Meds to double-check
Moderate interaction found
Before taking NOXygen Unflavored, check your medications if you use blood pressure drugs, lithium, corticosteroids, didanosine, sodium phosphates, tolvaptan, or any other sodium-containing medications — sodium in this product can affect how they work or raise your blood sodium to unsafe levels. Altogether, these interactions span 203 individual medications.
The bottom line
Scorecard at a glancePartially disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you take blood pressure medications, lithium, corticosteroids, or any other sodium-containing drug, check with us before starting this product — sodium can interfere with how those work. People with high blood pressure, heart disease, or kidney problems should avoid sodium supplements without medical guidance.
Talk to your pharmacist about whether this product fits your health picture and current medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about NOXygen Unflavored, straight from the product label.
| Brand | Purus |
|---|---|
| Barcode (UPC) | 855734002222 |
| Net contents | 112 Gram(s); 3.9 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 326488 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for NOXygen Unflavored by Purus, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 1 Gram(s) | 1% |
| Sodium | 150 mg | 7% |
| Sugar Alcohol | 1 Gram(s) | -- |
| NO3-T | 0 NP | -- |
| Hydromax | 1500 mg | -- |
| NOXygen Blend | 740 mg | -- |
| NO3-T | 0 NP | -- |
Other ingredients: Natural Flavors, Silica, Calcium Silicate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Pump Endurance Hydration
Zero Stimulants
NOXygen preworkout accelerator Blood flow & O2 amplifier
Formula
Substantiated Effects NOXygen is a stimulant-free preworkout additive designed to create an oxygen-sparing environment through enhancing vasodilation and blood flow with NO3-T sodium nitrate, while simultaneously volumizing muscle cells and increasing lean body mass with Hydromax water-soluble glycerine. NOXygen is perfect for both strength and endurance athletes.
Unflavored Natural flavor
Dietary Supplement with Hydromax & NO3-T nitrates
Suggested/Recommended/Usage/Directions
Suggested use: Add one to two servings to your preworkout beverage 15-30 minutes before training for maximum blood and oxygen delivery. For endurance training, mix with your intra workout or hydration beverage and consume throughout training. Simplified usage 1 Level scoop Add to your pre- or intra-workout Drink 15-30 prior to exercise
Brand IP Statement(s)
NO3-T Nitrate Technology NO3-T.com/patents NO3-T is a registered trademark of Thermolife International, LLC. For patent information, please visit www.NO3-T.com/patents.
General Statements
Follow us Facebook /Puruslabsofficial TikTok @Puruslabs Instagram @Puruslabs Visit Us www.PurusLabs.com
Questions/comments? Call 855.629.6328 or email [email protected]
40 true servings
Precautions
Warning: Consult a licensed healthcare practitioner before use. Discontinue use immediately if you experience any adverse reactions.
Do not use if you are currently pregnant, or nursing, have had or have a family history of heart disease, high blood pressure, stroke or any other disease, or using an MAOI, prescription drug, or over-the-counter drug.
Keep out of reach of children.
Warning: Consuming this product can expose you to chemicals including lead which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food.
Allergen warning: Produced in a facility that processes milk, eggs, soybeans, wheat, shellfish, fish oil, tree nuts, sesame, and peanuts.
Storage
Store in a cool, dry area away from direct sunlight.
Filled by weight, not volume
Seals/Symbols
Proudly and safely made in the USA with components and ingredients of domestic and international origin.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement with Hydromax & NO3-T nitrates
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
NOXygen Unflavored by Purus label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in NOXygen Unflavored by Purus
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2.8 Gram(s) Dosage formPowder Servings per container40 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sodium
Interacts with205 drugs
Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...
Sodium monograph & interactionsHydromax
NOXygen Blend
- › NO3-T
- › NO3-T
Other (inactive) ingredients: Natural Flavors, Silica, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.
NOXygen Unflavored by Purus Drug Interactions
HelloPharmacist Interaction Report
NOXygen Unflavored by Purus contains sodium, which interacts with multiple medication types.
The most serious concern involves blood pressure medications (antihypertensives) — sodium can reduce how well they work, potentially making it harder to control your blood pressure.
Read the full breakdown — every affected drug type, severity by severity
Sodium also affects lithium (used for bipolar disorder), where changes in your sodium intake can shift lithium levels in your blood and risk toxicity. It has similar Moderate-severity interactions with corticosteroids (which can cause sodium retention), didanosine, sodium phosphates, tolvaptan, and other sodium-containing drugs — all raising the risk of high blood sodium levels.
Two other ingredients in this product — NO3-T and Hydromax — we could not check; we hold no interaction data for them. The fourth ingredient, NOXygen Blend, is a group ingredient whose components are listed separately.
Run your exact medications through the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against NOXygen Unflavored?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in NOXygen Unflavored interact with 205 drugs. Click any drug to see the details.
1 of the 4 ingredients in NOXygen Unflavored interact with drugs. Each result below shows which ingredient is responsible. Sodium
DeserpidineHarmonyl
How Deserpidine interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Deserpidine interactionDeserpidine, HydrochlorothiazideOreticyl, Oreticyl Forte
How Deserpidine, Hydrochlorothiazide interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Deserpidine, Hydrochlorothiazide interactionDeserpidine, MethyclothiazideEnduronyl, Enduronyl Forte
How Deserpidine, Methyclothiazide interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Deserpidine, Methyclothiazide interactionDexamethasoneDecadron, Dexone, Dextenza, Dexycu, Hemady, Hexadrol +1 more
How Dexamethasone interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Dexamethasone interactionDibasic Sodium Phosphate, Monobasic Potassium Phosphate, Monobasic Sodium Phosphate Monohydrate (prescription Drug)K-Phos Neutral
How Dibasic Sodium Phosphate, Monobasic Potassium Phosphate, Monobasic Sodium Phosphate Monohydrate (prescription Drug) interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumSodium-containing Drugs Moderate
Interaction Summary
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
Read the full Sodium + Dibasic Sodium Phosphate, Monobasic Potassium Phosphate, Monobasic Sodium Phosphate Monohydrate (prescription Drug) interactionDidanosineVidex, Videx EC
How Didanosine interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumDidanosine (videx), Sodium-containing Drugs Moderate
Interaction Summary
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Read the full Sodium + Didanosine interactionDiltiazemAdizem-SR, Adizem-XL, Angitil SR, Angitil XL, Calcicard CR, Cardizem +23 more
How Diltiazem interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Diltiazem interactionDiltiazem, EnalaprilTeczem
How Diltiazem, Enalapril interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Diltiazem, Enalapril interactionDoxazosin MesylateCardura
How Doxazosin Mesylate interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Doxazosin Mesylate interactionEnalapril MaleateEpaned, Vasotec
How Enalapril Maleate interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Enalapril Maleate interactionEnalapril Maleate, FelodipineLexxel
How Enalapril Maleate, Felodipine interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Enalapril Maleate, Felodipine interactionEnalapril Maleate, HydrochlorothiazideVaseretic
How Enalapril Maleate, Hydrochlorothiazide interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Enalapril Maleate, Hydrochlorothiazide interactionEplerenoneInspra
How Eplerenone interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Eplerenone interactionEpoprostenolFlolan
How Epoprostenol interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Epoprostenol interactionEprosartanTeveten
How Eprosartan interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Eprosartan interactionEsmololBrevibloc
How Esmolol interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Esmolol interactionEthacrynic AcidEdecrin
How Ethacrynic Acid interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Ethacrynic Acid interactionFelodipinePlendil, Renedil
How Felodipine interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Felodipine interactionFenoldopamCorlopam
How Fenoldopam interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Fenoldopam interactionFludrocortisoneFlorinef Acetate
How Fludrocortisone interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Fludrocortisone interactionFluticasoneFlixotide, Flonase, Flovent, Seretide, Veramyst
How Fluticasone interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Fluticasone interactionFluticasone Furoate, Umeclidinium, VilanterolTrelegy Ellipta
How Fluticasone Furoate, Umeclidinium, Vilanterol interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Fluticasone Furoate, Umeclidinium, Vilanterol interactionFluticasone Furoate, Vilanterol TrifenatateBreo Ellipta
How Fluticasone Furoate, Vilanterol Trifenatate interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Fluticasone Furoate, Vilanterol Trifenatate interactionFosinoprilMonopril
How Fosinopril interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Fosinopril interactionFosinopril, HydrochlorothiazideMonopril HCT
How Fosinopril, Hydrochlorothiazide interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Fosinopril, Hydrochlorothiazide interactionFurosemideLasix
How Furosemide interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Furosemide interactionGuanabenz AcetateWytensin
How Guanabenz Acetate interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Guanabenz Acetate interactionGuanadrel SulfateHylorel
How Guanadrel Sulfate interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Guanadrel Sulfate interactionGuanethidine MonosulfateIsimil, Ismelin
How Guanethidine Monosulfate interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Guanethidine Monosulfate interactionGuanethidine, HydrochlorothiazideEsimil
How Guanethidine, Hydrochlorothiazide interacts with NOXygen Unflavored — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Guanethidine, Hydrochlorothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in NOXygen Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Sodium
Antihypertensive Drugs
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.
Corticosteroids
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.
Didanosine (Videx)
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.
Lithium
Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.
Sodium Phosphates
Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.
Sodium-Containing Drugs
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.
Tolvaptan (Samsca)
Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.
Brand information
Manufacturer and brand details for NOXygen Unflavored, from the product label.
Purus
See all Purus products- Name
- Purus Labs
- Street Address
- 3615 Francis Cir Suite 100
- City
- Alpharetta
- State
- GA
- ZipCode
- 30004
- Phone Number
- 855.629.6328
- Web Address
- www.puruslabs.com
NOXygen Unflavored by Purus: Common Questions
Does NOXygen Unflavored by Purus interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is sodium doing in a supplement?
Is this safe if I have high blood pressure?
Can I take this while pregnant?
What are NO3-T and Hydromax?
Will this affect my lithium?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if NOXygen Unflavored is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind NOXygen Unflavored’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
NOXygen Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 38 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sodium 38 references
- Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
- Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
- Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
- Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
- Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
- Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
- Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
- Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
- Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
- D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
- Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
- Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
- Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
- Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
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