Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

O.P.A. Ingredients & Drug Interactions

by Progressive Professional from Progressive Laboratories

O.P.A. label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking O.P.A. against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

O.P.A. is a dietary supplement by Progressive Professional from Progressive Laboratories with 3 active ingredients. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 106 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Inositol, Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against O.P.A. by Progressive Professional from Progressive Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with O.P.A. by Progressive Professional from Progressive Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of O.P.A. by Progressive Professional from Progressive Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Phosphorus” is listed as a grouped ingredient — the label gives one combined amount (125 mg) without saying how much of each component you get.

O.P.A. is a 3-ingredient liquid providing phosphorus, riboflavin (also called vitamin B2), and inositol. Riboflavin is a B vitamin your body needs to convert food into energy and keep cells healthy.

Inositol is a compound that works on cell signaling pathways in your body. The product also contains purified water as an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Polycystic ovary syndrome (PCOS) — rated "Possibly Effective" (Inositol) (Natural Medicines).
  • On file: Preterm labor — rated "Possibly Effective" (Inositol) (Natural Medicines).
  • On file: Metabolic syndrome — rated "Possibly Effective" (Inositol) (Natural Medicines).

The evidence we hold shows inositol is possibly effective for polycystic ovary syndrome (PCOS), metabolic syndrome, and preterm labor. For anxiety, diabetic neuropathy, and depression, inositol is rated possibly ineffective—the data doesn't support benefit for those uses.

We don't have effectiveness ratings for riboflavin or phosphorus in this product's context, so we can't speak to what this combination is designed to do overall.

The evidence, ingredient by ingredient Riboflavin Inositol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Riboflavin is considered very safe; your body clears excess through urine. It's needed during pregnancy and breastfeeding at recommended amounts, though check with your provider before taking high-dose supplements.

The most common side effects are dose-related nausea and bright yellow urine at higher doses; a small number of people in trials reported diarrhea or increased urination. Inositol is generally well tolerated at common doses, with mild digestive side effects like diarrhea, gas, and nausea being the most common.

It's been studied in pregnancy but is rated possibly safe—safety isn't fully established, so use only under medical supervision if you're pregnant. There isn't enough reliable data on inositol during breastfeeding, so check with your doctor about whether it's right for you.

We don't hold safety data for orthophosphoric acid.

Side effects, ingredient by ingredient Riboflavin Inositol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Inositol, Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 106 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this if you use antidiabetes drugs (insulin, metformin, sulfonylureas, or others)—inositol can lower blood sugar and might tip you into low blood sugar. If you're on tetracycline antibiotics, riboflavin may reduce their potency, though this hasn't been proven in humans.

For either class, confirm it's okay to combine them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

O.P.A. may be worth considering if you're looking to support PCOS, metabolic syndrome, or preterm labor—those are the uses inositol has some evidence for. If you take tetracycline antibiotics or diabetes medications, you'll want to check with your doctor or pharmacist first, since this product could affect how those work.

Talk it over with your own healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about O.P.A., straight from the product label.

Brand Progressive Professional from Progressive Laboratories
Barcode (UPC) 351821004143
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 299204
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for O.P.A. by Progressive Professional from Progressive Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 mL
Maximum serving Sizes:
4 mL
Servings per container
15
UPC/BARCODE
351821004143
IngredientAmount% DV
Phosphorus125 mg13%
Riboflavin100 mcg6%
Inositol21 mg--
Orthophosphoric Acid395 mg--

Other ingredients: Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Four to five droppers diluted with water daily, or more, as directed by a health care professional.

Precautions

Sold only for dispensing by a licensed health care professional.

Not to be used by pregnant or lactating women.

Do not use if seal around cap is broken or missing.

Keep out of reach of children.

Formulation

Progressive Laboratories packaged this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Certified GMP Compliant GMP Good Manufacturing Practices 21 CFR 111

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

O.P.A. by Progressive Professional from Progressive Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

O.P.A. label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in O.P.A. by Progressive Professional from Progressive Laboratories

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phosphorus

125 mg per serving
  • › Orthophosphoric Acid

Riboflavin

Interacts with
20 drugs
100 mcg per serving

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Inositol

Interacts with
86 drugs
21 mg per serving

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, m...

Inositol monograph & interactions

Other (inactive) ingredients: Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

O.P.A. by Progressive Professional from Progressive Laboratories Drug Interactions

Want to check YOUR meds against O.P.A.?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
106Drugs
106 Moderate

Ingredients driving the most interactions

Inositol 86
Riboflavin 20

Individual Drug Interactions

The ingredients in O.P.A. interact with 106 drugs. Click any drug to see the details.

2 of the 3 ingredients in O.P.A. interact with drugs. Each result below shows which ingredient is responsible. Inositol Riboflavin

Each ingredient & the kinds of drugs it affects

For each ingredient in O.P.A. with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Inositol1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that inositol lowers blood glucose levels and glycated hemoglobin (HbA1c) levels in patients with diabetes.

Likelihood Possible Evidence A
Inositol full monograph & interactions

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for O.P.A., from the product label.

Progressive Professional from Progressive Laboratories

See all Progressive Professional from Progressive Laboratories products
Name
Progressive Laboratories, Inc.
City
Irving
State
Texas
ZipCode
75038
Phone Number
1-800-527-9512
Pharmacist Counseling Corner

O.P.A. by Progressive Professional from Progressive Laboratories: Common Questions

Does O.P.A. by Progressive Professional from Progressive Laboratories interact with any medications?
Yes. Based on its ingredients, O.P.A. has a known interaction with 106 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
O.P.A. contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Riboflavin is needed in pregnancy and safe at recommended doses, though check with your provider about higher amounts. Inositol is rated possibly safe in pregnancy but hasn't been fully studied, so use only under medical supervision if you're expecting. Talk to your doctor before starting.
Can I take this while breastfeeding?
Riboflavin is needed while breastfeeding and safe at standard doses; ask your provider about higher amounts. We don't have enough reliable information on inositol during breastfeeding, so check with your doctor first.
Will this help my PCOS?
Inositol, one of the three ingredients, is rated possibly effective for PCOS. That means there's some evidence it may help, but it's not proven. Talk to your doctor about whether this product is right for your situation.
What side effects should I expect?
Most commonly, you might notice nausea (especially at higher doses of riboflavin), bright yellow urine, or mild digestive upset like diarrhea or gas from inositol. These are generally mild, and excess riboflavin is simply cleared through your urine.
What is inositol, and what does it do?
Inositol is a compound that helps cells communicate and process signals in your body. It's found in foods and your body makes some too—this supplement adds to your intake for specific health goals like PCOS or metabolic support.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

O.P.A. label
Go deeper

The Full Monographs Behind O.P.A.’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph → Herb & supplement monograph

Inositol

Interacts with 86 drugs

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, mood, and metabolic concerns. The stronge...

Read the full Inositol monograph →
Sources

Sources & How We Checked

O.P.A.'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Inositol 14 references
  1. Palatnik A, Frolov K, Fux M, Benjamin J. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J Clin Psychopharmacol 2001;21:335-9.. PubMed
  2. Allan SJ, Kavanagh GM, Herd RM, Savin JA. The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial. Br J Dermatol 2004;150:966-9. PubMed
  3. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
  4. Kamenov Z, Kolarov G, Gateva A, Carlomagno G, Genazzani AD. Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance. Gynecol Endocrinol 2015;31(2):131-5. PubMed
  5. Matarrelli B, Vitacolonna E, D'Angelo M, et al. Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized controlled trial. J Matern Fetal Neonatal Med 2013;26(1 PubMed
  6. Mukai T, Kishi T, Matsuda Y, Iwata N. A meta-analysis of inositol for depression and anxiety disorders. Hum Psychopharmacol 2014;29(1):55-63. PubMed
  7. Farren M, Daly N, McKeating A, Kinsley B, Turner MJ, Daly S. The Prevention of Gestational Diabetes Mellitus With Antenatal Oral Inositol Supplementation: A Randomized Controlled Trial. Diabetes Care. 2017;40(6):759-63. PubMed
  8. Zheng X, Liu Z, Zhang Y, et al. Relationship Between Myo-Inositol Supplementary and Gestational Diabetes Mellitus: A Meta-Analysis. Medicine (Baltimore). 2015;94(42):e1604. PubMed
  9. Crawford TJ, Crowther CA, Alsweiler J, Brown J. Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes. Cochrane Database Syst Rev. 2015;(12):CD011507. PubMed
  10. Maurizi AR, Menduni M, Del Toro R, et al. A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes. Acta Diabetol. 2017;54(4):361-65. PubMed
  11. Leppink EW, Redden SA, Grant JE. A double-blind, placebo-controlled study of inositol in trichotillomania. Int Clin Psychopharmacol. 2017;32(2):107-14. PubMed
  12. Lam S, Mandrekar SJ, Gesthalter Y. A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. Cancer Prev Res (Phila). 2016;9(12):906-14.
  13. Wozniak J, Faraone SV, Chan J, et al. A randomized clinical trial of high eicosapentaenoic acid omega-3 fatty acids and inositol as monotherapy and in combination in the treatment of pediatric bipolar spectrum disorders: a pilot study. J Clin Psychiatry. PubMed
  14. Vitale SG, Corrado F, Caruso S, et al. Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes - a randomized and open-label, placebo-

See these in context on the Inositol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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