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Dietary supplement

Organic Lion's Mane Powder Ingredients & Drug Interactions

by Herb Affair

Organic Lion's Mane Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Lion's Mane Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Lion's Mane Powder is a dietary supplement by Herb Affair with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Lion's Mane Powder by Herb Affair

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Lion's Mane Powder by Herb Affair — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Lion's Mane Powder by Herb Affair

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 8, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Certified Organic Mushroom Powder Blend” is a proprietary blend — the label gives one combined amount (2 Gram(s)) without saying how much of each component you get.

The product lists one active ingredient: Lion's Mane, a mushroom powder that is part of a certified organic mushroom powder blend. The blend's other components are not individually listed in our data.

Oats, myceliated is listed as an inactive ingredient. It is not an active ingredient, and our data does not describe any further inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support brain health.
  • We looked for evidence on: Alzheimer disease, Cognitive function, Cognitive impairment, Dementia, Memory, Parkinson disease — and 3 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Dementia, Memory, and more.

Lion's Mane has insufficient reliable evidence to rate for Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment. In other words, the evidence for these uses is not established in the data we hold.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's Mane is generally well tolerated as a food, but supplement safety has not been well studied long-term. Common side effects include gastrointestinal discomfort, nausea, and skin rash.

Its safety notes advise avoiding it during pregnancy and while breastfeeding, because there isn't enough safety data to know it is safe in either situation.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check blood thinners (anticoagulants) and antiplatelet drugs first, since the documented concern is increased bleeding risk, rated Moderate. Next, check diabetes medicines (antidiabetes drugs) and immunosuppressants (drugs that dampen the immune system), both also rated Moderate.

Confirm these with your own doctor or pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

This powder may appeal to people curious about lion's mane, but the evidence for its uses is not established. If you take blood thinners, diabetes medicines, or immune-dampening drugs, or if you are pregnant or breastfeeding, talk it over with your own doctor or pharmacist before using it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Lion's Mane Powder, straight from the product label.

Brand Herb Affair
Barcode (UPC) 196852033959
Net contents 7.05 Ounce(s); 200 Gram(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 321050
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Lion's Mane Powder by Herb Affair, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gram(s)
Maximum serving Sizes:
2 Gram(s)
Servings per container
100
UPC/BARCODE
196852033959
IngredientAmount% DV
Calories10 Calorie(s)--
Certified Organic Mushroom Powder Blend2 Gram(s)--
Lion's Mane0 NP--

Other ingredients: Oats, Myceliated

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

USDA Organic

Non GMO Gluten free Soy free

Vegan

Certified Organic by: MOSA

Seals/Symbols

USDA Organic

Formula

The smartest fungi around - Lion's Mane. This incredible mushroom may look and get its name from a mane of a lion, but it actually can help fire up your brainwaves! It is touted for its ability to support brain health, which may help to improve mental clarity and nerve health. With Lions Mane, your next big idea is right around the corner.

Suggested/Recommended/Usage/Directions

How to use: Add 1 serving (1 tsp) every day to your coffee, water or milk, or make your own supplement using a capsule filler.

General Statements

Instagram #MakeHealthHappen

2 grams per scoop is an average. Scooping technique may vary by individual and may yield slight more or slightly less than 2 grams. Questions or comments? 866-445-9040

Storage

Note: Store in a cool dry place. This product is packaged by weight, not by volume. Settling of contents occurs over time and cannot be avoided.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Lion's Mane Powder by Herb Affair label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Lion's Mane Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Lion's Mane Powder by Herb Affair

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Gram(s) Dosage formPowder Servings per container100 Amounts shown are per serving.

Certified Organic Mushroom Powder Blend

2 Gram(s) per serving

Other (inactive) ingredients: Oats, Myceliated. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Lion's Mane Powder by Herb Affair Drug Interactions

Want to check YOUR meds against Organic Lion's Mane Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane 327

Individual Drug Interactions

The ingredients in Organic Lion's Mane Powder interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Lion's Mane Powder interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Lion's Mane Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Lion's Mane Powder, from the product label.

Herb Affair

See all Herb Affair products
Name
Herb Affair
City
Libertyville
State
IL
ZipCode
60048
Phone Number
866-445-9040
Web Address
HerbAffair.com
Pharmacist Counseling Corner

Organic Lion's Mane Powder by Herb Affair: Common Questions

Does Organic Lion's Mane Powder by Herb Affair interact with any medications?
Yes. Based on its ingredients, Organic Lion's Mane Powder has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Lion's Mane Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take during pregnancy?
The safety notes advise avoiding Lion's Mane during pregnancy because there isn't enough safety data. For advice about your own situation, talk with your doctor or pharmacist.
What are the side effects of Lion's Mane?
The most common side effects are gastrointestinal discomfort, nausea, and skin rash. Lion's Mane is generally well tolerated as a food, but long-term supplement safety has not been well studied.
Does Lion's Mane work for memory?
We can't say. Its evidence for cognitive function and cognitive impairment is insufficient to rate, so the benefit for memory is not established in the data we hold.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Lion's Mane Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Lion's Mane Powder label
Go deeper

The Full Monographs Behind Organic Lion's Mane Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Organic Lion's Mane Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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