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Dietary supplement

Organic Tribulus 750 mg Ingredients & Drug Interactions

by Herbal Secrets

Organic Tribulus 750 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Tribulus 750 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Tribulus 750 mg is a dietary supplement by Herbal Secrets with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Puncture Vine powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Tribulus 750 mg by Herbal Secrets

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Tribulus 750 mg by Herbal Secrets — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Tribulus 750 mg by Herbal Secrets

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Organic Tribulus 750 mg contains one active ingredient: organic Puncture Vine powder, a plant extract from the tribulus plant, at 750 mg per serving. The tablet also includes rice dextrin and organic gum acacia as inactive ingredients (fillers and binders).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Tribulus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Tribulus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sexual dysfunction — rated "Possibly Effective" (Natural Medicines).

Tribulus shows possibly effective evidence for sexual dysfunction in adults. However, the evidence for athletic performance is rated possibly ineffective, and there isn't enough reliable evidence to rate it for benign prostatic hyperplasia (enlarged prostate).

If you're considering this supplement for sexual health, the science suggests it may help—but for athletic goals, the data doesn't support its use.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is often well tolerated in the short term for healthy adults, but long-term safety data and product quality information are limited. The most common side effects are gastrointestinal and include abdominal pain, cramping, nausea, vomiting, diarrhea, and constipation—though one study found these occurred at similar rates in people taking tribulus and those taking placebo.

Rare serious effects reported include liver or kidney injury, seizures, and chronic painful erection. The safety data advises against use during pregnancy because it may affect hormones, and there isn't enough reliable information to recommend it while breastfeeding—talk with your doctor or pharmacist about whether it's right for you if you're pregnant, trying to become pregnant, or nursing.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you're on blood pressure medications, diabetes drugs, or lithium. Tribulus can lower blood pressure and blood sugar, and may raise lithium levels—all Moderate interactions that could affect how your medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Organic Tribulus 750 mg may be worth considering if you're interested in sexual function support and have talked it over with your doctor. If you take blood pressure drugs, diabetes medications, or lithium, you'll want to check your exact medications with your doctor or pharmacist before starting—this product can interact with all three.

Long-term safety data are sparse, so this is best used short-term and under guidance from your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Tribulus 750 mg, straight from the product label.

Brand Herbal Secrets
Barcode (UPC) 819209021118
Net contents 120 Organic Tablet(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 251268
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Tribulus 750 mg by Herbal Secrets, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Organic Tablet(s)
Maximum serving Sizes:
1 Organic Tablet(s)
Servings per container
120
UPC/BARCODE
819209021118
IngredientAmount% DV
organic Puncture Vine powder750 mg--

Other ingredients: Rice Dextrin, organic Gum Acacia

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Herbal Secrets Organic Tribulus is made from the roots and fruits of a plant called Puncture Vine or Tribulus terrestris. Tribulus has a long history of use in traditional Ayurveda practices, however it is best known for its benefits in the male reproductive system. Tribulus supports sexual and athletic performance in men. Tribulus promotes cardiovascular and digestive functions.

100% Natural

Contains No: Preservatives, artificial colors, flavors or sweeteners, milk, lactose, soy, gluten, wheat, yeast, or fish.

Certified Organic by: Baystate Organic Certifiers

USDA Organic

Supports lean muscle mass & strength gain Supports overall health & well-being

Suggested/Recommended/Usage/Directions

Suggest Use: As a dietary supplement, adults take one (1) organic tablet twice daily, preferably with a meal or as directed by a health care professional.

Precautions

Caution: Not intended for use by pregnant or nursing women and children under the age of 18. If you are taking any medication(s) or have any medical condition, consult your doctor before you use.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Caution: Not intended for use by pregnant or nursing women and children under the age of 18.

Discontinue use and consult your doctor if any adverse reactions occur.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Visit us online amazingnutrition.com Product Code 21118

Seals/Symbols

Made in the USA

USDA Organic

GMP Good Manufacturing Produce Quality Produce

FDA Statement of Identity

Natural Dietary Supplement

Formula

Certified Organic Ayurvedic Herb

Promotes Men's reproductive health

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Tribulus 750 mg by Herbal Secrets label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Tribulus 750 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Tribulus 750 mg by Herbal Secrets

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Organic Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.

Organic Puncture Vine powder

Interacts with
259 drugs
750 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Organic Puncture Vine powder monograph & interactions

Other (inactive) ingredients: Rice Dextrin, Organic Gum Acacia. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Tribulus 750 mg by Herbal Secrets Drug Interactions

Want to check YOUR meds against Organic Tribulus 750 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

organic Puncture Vine powder 259

Individual Drug Interactions

The ingredients in Organic Tribulus 750 mg interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Tribulus 750 mg interact with drugs. Each result below shows which ingredient is responsible. organic Puncture Vine powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Tribulus 750 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Puncture Vine powder3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
organic Puncture Vine powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Tribulus 750 mg, from the product label.

Herbal Secrets

See all Herbal Secrets products
Name
Herbal Secrets
Street Address
629 Grove Street
City
Jersey City
State
NJ
ZipCode
07310
Pharmacist Counseling Corner

Organic Tribulus 750 mg by Herbal Secrets: Common Questions

Does Organic Tribulus 750 mg by Herbal Secrets interact with any medications?
Yes. Based on its ingredients, Organic Tribulus 750 mg has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Tribulus 750 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against tribulus during pregnancy because it may affect hormones and safety isn't established. There also isn't enough reliable information to recommend it while breastfeeding. Talk with your doctor or pharmacist about your specific situation before taking it.
What are the most common side effects?
The most common side effects are gastrointestinal—abdominal pain, cramping, nausea, vomiting, diarrhea, and constipation. However, in one study, these complaints occurred at similar rates in people taking tribulus and those taking placebo, so they may not all be from the supplement itself.
Does this really work for sexual function?
Tribulus is rated possibly effective for sexual dysfunction in adults, meaning there's some research support but it's not definitive. Results vary person to person, so you may need to try it to see if it helps you.
What is Puncture Vine, and why is it in this product?
Puncture Vine (tribulus) is a plant traditionally used to support sexual function and athletic performance. This supplement uses the powder form of the whole plant.
How long is it safe to take this supplement?
Tribulus appears well tolerated in the short term, but long-term safety data are limited. If you're considering using it regularly, talk with your doctor or pharmacist about how long is appropriate for you.
Will this help me with athletic performance?
No—tribulus is rated possibly ineffective for athletic performance, so the evidence doesn't support using it for that goal.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Tribulus 750 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Tribulus 750 mg label
Go deeper

The Full Monographs Behind Organic Tribulus 750 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Organic Tribulus 750 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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