Major interaction on record — check this product against your medications before combining. Based on 7 of 11 ingredients. Check your meds →
Dietary supplement

Overtime Ingredients & Drug Interactions

by Apollon Nutrition

Overtime label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Overtime against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Overtime is a dietary supplement by Apollon Nutrition with 11 active ingredients. Its ingredients are commonly taken for mental focus and alertness, coping with stress, fatigue and sleep loss.Based on those ingredients, 1,498 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Rhodiola rosea, Caffeine Anhydrous, Lion's Mane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Overtime by Apollon Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Overtime by Apollon Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Overtime by Apollon Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 11 of its 11 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Overtime contains 11 active ingredients designed to support mental focus and physical endurance. L-tyrosine is an amino acid that serves as a building block for neurotransmitters and thyroid hormones.

The product includes two forms of caffeine—caffeine anhydrous and di caffeine malate—for stimulant effect, along with theacrine, which has stimulant properties. Alpha-GPC is a choline compound that supports brain function.

Noopept, N-phenethyl dimethylamine, and B-phenylethylamine are stimulant compounds. Lion's mane mushroom and rhodiola rosea are herbal adaptogens traditionally used to support cognition and stress response.

Rauwolfia vomitoria root bark extract is also included. The capsules contain inactive ingredients: gelatin, dicalcium phosphate, silicon dioxide, and magnesium stearate.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: sustained energy and mental focus enhancement.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Cognitive function, Fatigue, Mental alertness, endurance — and 3 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Caffeine is rated "Likely Effective" for Mental alertness.
  • Also on file: Tyrosine is rated "Possibly Effective" for Cognitive function.

The evidence for Overtime's ingredients is mixed. L-tyrosine shows possibly effective results for memory and cognitive function, though it is rated possibly ineffective for athletic performance.

Caffeine is rated likely effective for mental alertness and athletic performance. Alpha-GPC is possibly effective for Alzheimer disease but rated insufficient evidence for cognitive function and other brain conditions.

Lion's mane, rhodiola, and theacrine all show insufficient evidence to rate for cognitive function, mental alertness, fatigue, and athletic performance. Noopept, N-phenethyl dimethylamine, B-phenylethylamine, and Rauwolfia vomitoria—we hold no effectiveness data in our files for these ingredients.

The evidence, ingredient by ingredient Tyrosine Caffeine Alpha-gpc Phenethylamine (pea) Lion's Mane Mushroom Rhodiola Theacrine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-tyrosine is generally well tolerated but carries caution advisories: safety data is limited, and you should talk with a healthcare provider before regular use, especially during pregnancy and breastfeeding where data is insufficient. The most common side effects are fatigue, headache, heartburn, and nausea; larger doses can worsen these.

Caffeine is generally safe in moderate amounts for healthy adults but high doses carry serious risks. Pregnancy safety is uncertain (rated possibly safe and possibly unsafe), so ask your doctor about safe limits; small amounts pass into breast milk and moderate intake is usually acceptable but can affect the baby.

Alpha-GPC is generally well tolerated but long-term safety is not fully established; avoid during pregnancy and breastfeeding unless directed by your doctor. Rare adverse effects include dizziness, headache, insomnia, and stroke.

B-phenylethylamine may affect heart rate and blood pressure; avoid during pregnancy and breastfeeding due to insufficient data. Lion's mane is well tolerated as a food but supplement safety has not been well studied long-term; avoid during pregnancy and breastfeeding.

Common side effects are gastrointestinal discomfort, nausea, and rash. Rhodiola is generally well tolerated for short-term use but long-term safety is unclear; avoid during pregnancy and breastfeeding.

Most common effects are dizziness and dry mouth or excess saliva. Theacrine appears well tolerated short-term but long-term safety is not established; avoid during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Tyrosine Caffeine Alpha-gpc Phenethylamine (pea) Lion's Mane Mushroom Rhodiola Theacrine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Rhodiola, Caffeine, Tyrosine, Alpha-gpc, Phenethylamine (pea), among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,499 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking Overtime if you use ephedrine or ephedra (Major severity risk of dangerous stimulant effects). Also double-check moderate-severity risks: levodopa, thyroid hormones, seizure medications (phenobarbital, carbamazepine), stress-test agents (dipyridamole), antipsychotics (clozapine), sleeping pills (pentobarbital), anticoagulants (blood thinners), antidiabetes drugs, blood-pressure medications (especially losartan), antidepressants or other serotonergic drugs, MAOIs, immunosuppressants, and certain antibiotics (quinolones) or acid-reflux drugs (cimetidine).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Overtime is a stimulant-heavy cognitive support formula best suited to adults seeking mental alertness and work endurance who don't take medications. If you take any prescription drugs—especially medications for Parkinson disease, thyroid conditions, seizures, depression, blood clotting, diabetes, blood pressure, heart rhythm, immune health, or sedation—check your list against the search tool on this page before starting.

Talk with your doctor or pharmacist about whether this product fits your health and medication profile.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Overtime, straight from the product label.

Brand Apollon Nutrition
Barcode (UPC) 850862007279
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 235548
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Overtime by Apollon Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
20
UPC/BARCODE
850862007279
IngredientAmount% DV
L-Tyrosine200 mg--
Caffeine Anhydrous300 mg--
Noopept30 mg--
Alpha GPC600 mg--
Di Caffeine Malate200 mg--
N-Phenethyl Dimethylamine300 mg--
B-Phenylethylamine500 mg--
Rauwolfia vomitoria root bark extract2.5 mg--
Lion's Mane600 mg--
Rhodiola rosea200 mg--
Theacrine160 mg--

Other ingredients: Gelatin, Dicalcium Phosphate, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The night's young, and you're ready to cut loose. The only problem is you're completely drained thanks to your overbearing boss who rides you harder than a stolen rental car. To fuel your night of raucous, rambunctious antics, you need Overtime.

Formulation

Overtime is an all-natural mood and energy enhancer that keeps you going strong way pat "last call".

Nootropic / Limitless energy

Clean formulation No fillers No additives No artificial colors

Suggested/Recommended/Usage/Directions

Suggested use: Take 6 capsules 30 minutes before an event when long-lasting sustained energy and focus are needed.

Precautions

Do not exceed 6 capsules in a 24-hour period!

Warning: This product is only intended to be consumed by healthy adults 18 years of age or older.

Do not use if you are pregnant, breast feeding, sensitive to caffeine, have known medical conditions (including but not limited to kidney, heart or liver disease) or are taking prescription or OTC medication(s).

Consult with you health care practitioner before using this product. Do not use under extreme conditions of heat, cardiovascular exertion or dehydration.

Do not use with caffeine or stimulant-containing medications, foods or beverages because too much caffeine my cause nervousness, irritability, sleeplessness and occasionally rapid heartbeat.

Discontinue use and consult with your health care professional if you experience any adverse reaction to this product. Do not exceed recommended serving.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Apollon Nutrition and Overtime are trademarks of Apollon Nutrition LLC 2019, All rights reserved.

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool dry place.

Seals/Symbols

Made in USA of domestic and international ingredients FDA Registered Facility GMP Good Manufacturing Practices Consistent Quality

Formula

TeaCrine

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Overtime by Apollon Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Overtime label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Overtime by Apollon Nutrition

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Capsule(s) Dosage formCapsule Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Tyrosine

Interacts with
21 drugs
200 mg per serving

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...

L-Tyrosine monograph & interactions

Caffeine Anhydrous

Interacts with
655 drugs
300 mg per serving

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredn...

Caffeine Anhydrous monograph & interactions

Noopept

30 mg per serving

Alpha GPC

Interacts with
16 drugs
600 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha GPC monograph & interactions

Di Caffeine Malate

Interacts with
655 drugs
200 mg per serving

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredn...

Di Caffeine Malate monograph & interactions

N-Phenethyl Dimethylamine

300 mg per serving

B-Phenylethylamine

Interacts with
187 drugs
500 mg per serving

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. R...

B-Phenylethylamine monograph & interactions

Rauwolfia vomitoria root bark extract

2.5 mg per serving Form: Rauwolscine

Lion's Mane

Interacts with
327 drugs
600 mg per serving Form: Beta-Glucans

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane monograph & interactions

Rhodiola rosea

Interacts with
1,271 drugs
200 mg per serving Form: Rosavin, Salidroside

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Rhodiola rosea monograph & interactions

Theacrine

Interacts with
248 drugs
160 mg per serving

Theacrine is a caffeine-like compound found naturally in certain tea plants and is sold in supplements for energy, focus, and mood. Early human studie...

Theacrine monograph & interactions

Other (inactive) ingredients: Gelatin, Dicalcium Phosphate, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Overtime by Apollon Nutrition Drug Interactions

Want to check YOUR meds against Overtime?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,498Drugs
8 Major 1,192 Moderate 298 Minor

Ingredients driving the most interactions

Rhodiola rosea 1,271
Caffeine Anhydrous 655
Lion's Mane 327
Theacrine 248
B-Phenylethylamine 187

Individual Drug Interactions

The ingredients in Overtime interact with 1,498 drugs. Click any drug to see the details.

7 of the 11 ingredients in Overtime interact with drugs. Each result below shows which ingredient is responsible. Rhodiola rosea Caffeine Anhydrous Lion's Mane Theacrine B-Phenylethylamine L-Tyrosine Alpha GPC

Each ingredient & the kinds of drugs it affects

For each ingredient in Overtime with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rhodiola rosea10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B
Rhodiola rosea full monograph & interactions

Caffeine Anhydrous41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Caffeine Anhydrous full monograph & all 41 interactions

Lion's Mane3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane full monograph & interactions

Theacrine1 drug type · 248 drugs

Cns Depressants

Theoretically, theacrine might alter the effects of CNS depressants.
Animal research shows that low doses of theacrine have sedating effects, whereas high doses might have stimulant effects. Depending on the dose of theacrine used, it might increase or decrease the effects of CNS depressants. However, these effects have not yet been reported in humans.

Likelihood Possible Evidence D
Theacrine full monograph & interactions

B-Phenylethylamine2 drug types · 187 drugs

Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking phenethylamine concomitantly with MAOIs may increase adverse effects.
In humans, phenethylamine is oxidized by MAO-B to form the inactive metabolite phenylacetic acid. Animal research shows that administering an MAOI prior to phenethylamine increases the amphetamine-like effects of phenethylamine. However, low-quality clinical research has used phenethylamine with selegiline, an MAOI, with apparent safety.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.
Animal research shows that phenethylamine increases levels of serotonin, norepinephrine, and dopamine. Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of additive serotonergic adverse effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, low-quality clinical research has used phenethylamine with selegiline, a monoamine oxidase inhibitor (MAOI), with apparent safety.

Likelihood Possible Evidence D
B-Phenylethylamine full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions

Alpha GPC1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha GPC full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Overtime, from the product label.

Apollon Nutrition

See all Apollon Nutrition products
Name
Apollon Nutrition
Street Address
160 Talmadge Road
City
Edison
State
NJ
ZipCode
08817
Phone Number
732-985-8576
Web Address
ApollonNutrition.com
Pharmacist Counseling Corner

Overtime by Apollon Nutrition: Common Questions

Does Overtime by Apollon Nutrition interact with any medications?
Yes. Based on its ingredients, Overtime has a known interaction with 1,498 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Overtime contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Overtime safe to take while pregnant?
The data isn't clear enough. L-tyrosine, alpha-GPC, B-phenylethylamine, lion's mane, rhodiola, and theacrine all lack sufficient pregnancy safety information, and some are best avoided. Caffeine is rated uncertain (possibly safe and possibly unsafe), so ask your doctor about safe limits. Talk with your doctor or pharmacist before taking Overtime if you're pregnant or planning pregnancy.
Can I take this while breastfeeding?
Several ingredients lack breastfeeding safety data and are best avoided: L-tyrosine, alpha-GPC, B-phenylethylamine, lion's mane, rhodiola, and theacrine. Caffeine does pass into breast milk, and while moderate amounts are usually considered acceptable, it can affect the baby. Talk with your doctor or pharmacist about whether Overtime is right for you.
What's the most serious interaction this product has?
Caffeine in this product can cause major, life-threatening reactions if combined with ephedrine or ephedra—potentially leading to very high blood pressure or heart attack. If you take or use anything containing ephedrine or ephedra, do not use Overtime without checking with your doctor or pharmacist first.
Does L-tyrosine actually help with focus and memory?
L-tyrosine is rated possibly effective for memory and cognitive function, meaning some evidence supports it but research is not conclusive. It's rated possibly ineffective for athletic performance. Results vary by person.
What are the common side effects of this product?
Caffeine commonly causes anxiety, jitteriness, restlessness, insomnia, headache, nausea, and diarrhea. L-tyrosine may cause fatigue, headache, heartburn, and nausea. At higher doses, side effects can worsen. Alpha-GPC and lion's mane may cause headache, dizziness, or gastrointestinal discomfort. Rhodiola may cause dizziness or dry mouth.
Are there any ingredients you couldn't check for interactions?
Yes. We hold no interaction data for Noopept, N-phenethyl dimethylamine, or Rauwolfia vomitoria root bark extract, so we can't tell you whether they interact with your medications. Use the search tool below to check your specific prescriptions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Overtime label
Go deeper

The Full Monographs Behind Overtime’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Phenethylamine (pea)

Interacts with 187 drugs

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. Reliable human research on the supplement...

Read the full Phenethylamine (pea) monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Rhodiola

Interacts with 1,271 drugs

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...

Read the full Rhodiola monograph → Herb & supplement monograph

Theacrine

Interacts with 248 drugs

Theacrine is a caffeine-like compound found naturally in certain tea plants and is sold in supplements for energy, focus, and mood. Early human studies suggest it may give a stimulant-like b...

Read the full Theacrine monograph →
Sources

Sources & How We Checked

Overtime's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 273 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Caffeine 236 references
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Alpha-gpc 4 references
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Phenethylamine (pea) 9 references
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See these in context on the Phenethylamine (pea) monograph →

Lion's Mane Mushroom 6 references
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See these in context on the Lion's Mane Mushroom monograph →

Rhodiola 13 references
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See these in context on the Rhodiola monograph →

Theacrine 1 reference
  1. Xu JK, Kurihara H, Zhao L, Yao XS. Theacrine, a special purine alkaloid with sedative and hypnotic properties from Cammelia assamica var. kucha in mice. J Asian Nat Prod Res 2007;9(6-8):665-72.

See these in context on the Theacrine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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