Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

P6 Extreme Ingredients & Drug Interactions

by Cellucor

P6 Extreme label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking P6 Extreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

P6 Extreme is a dietary supplement by Cellucor with 2 active ingredients. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus alatus extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against P6 Extreme by Cellucor

Ask about any prescription or over-the-counter medication and we check it for interactions with P6 Extreme by Cellucor — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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Computed from our clinical databases

HelloPharmacist Scorecard of P6 Extreme by Cellucor

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The stated purpose hasn't been mapped to our evidence data yet.

Why this rating?
  • We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.
Known Interaction Concern
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Safety Information
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about P6 Extreme, straight from the product label.

Brand Cellucor
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2013
DSLD ID 18969
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for P6 Extreme by Cellucor, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
IngredientAmount% DV
Tribulus alatus extract250 mg--
P6 Extreme Blend947 mg--

Other ingredients: Magnesium Stearate, Silicon Dioxide, Capsule Shell

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

KIT INCLUDES: P6 EXTREME(TM) 120 CAPSULES NO3 CHROME(TM) 90 CAPSULES C4 EXTREME(TM) WATERMELON 30 SERVING C4 EXTREME(TM) ICY BLUE RAZZ 30 SERVING COR-PERFORMANCE B-BCAA(TM) 30 SERVING SUPER HD(TM) 10 CAPSULES SUPER SPORT(TM) VANILLA CREME 18g SUPER SPORT(TM) MILK CHOCOLATE 18.3g BONUS VORTEX(TM) PORTABLE MIXER & CELLUCOR(R) HOODIE

P6 EXTREME(TM)

General Statements

LIMITED EDITION

COR-PERFORMANCE SERIES

OVER $350 VALUE

Suggested/Recommended/Usage/Directions

SUGGESTED USE: As a dietary supplement for adults, take 2 capsules in the morning with or without food. Take 2 capsules in the evening before bed with or without food. Use for up to 8 weeks in a cycle then discontinue use for 4 weeks before starting a new cycle.

Precautions

Consult a health care provider before using this or any dietary supplement product, if you have or suspect you have any medical condition or are taking any other prescription, over-the-counter or dietary supplement product.

Do not use this product if you have a serious medical condition.

WARNING: This product is only intended for use by healthy adult men, 18 years of age or older. NOT FOR USE BY WOMEN.

This product contains Black Cohosh which must not be used while pregnant or nursing.

IMPORTANT DISCLOSURE: This product may contain legal dietary ingredients that are prohibited by Sports as banned or prohibited substances ("PS"). Due to the unique restrictions of amateur and professional sports organizations do not take this product if you are subject to PS testing without the approval and/or authorization of the organization, entity, agency or governing body that requires the testing.

This product was produced in a facility that may also process ingredients containing milk, egg, soybeans, shellfish, fish, treenuts and peanuts.

Discontinue use and call a health care professional immediately if you experience any adverse reaction to taking this product. Follow label instructions and do not exceed recommendations for Suggested Use.

KEEP OUT OF REACH OF CHILDREN.

Seals/Symbols

Chrome Series 3RD GENERATION

Formula

CONTAINS: SOY.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

P6 Extreme by Cellucor label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

P6 Extreme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in P6 Extreme by Cellucor

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Tribulus alatus extract

Interacts with
259 drugs
250 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus alatus extract monograph & interactions

P6 Extreme Blend

947 mg per serving Form: Agaricus bisprous (fruit) extract, Bayberry (bark) extract, Beta-Sitosterol, Black Cohosh (root) extract, Ovine Placenta Powder, Salvia sclarea (whole plant) extract, Stinging Nettle (root) extract, Wild Yam (root) extract

Other (inactive) ingredients: Magnesium Stearate, Silicon Dioxide, Capsule Shell. These complete the product’s ingredient list but are not active constituents.

Interaction report

P6 Extreme by Cellucor Drug Interactions

P6 Extreme contains 2 ingredients, and 1 of them has known drug interactions. Altogether it interacts with 259 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against P6 Extreme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus alatus extract 259

Individual Drug Interactions

The ingredients in P6 Extreme interact with 259 drugs. Click any drug to see the details.

1 of the 2 ingredients in P6 Extreme interact with drugs. Each result below shows which ingredient is responsible. Tribulus alatus extract

Each ingredient & the kinds of drugs it affects

For each ingredient in P6 Extreme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus alatus extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus alatus extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for P6 Extreme, from the product label.

Cellucor

See all Cellucor products
Name
Cellucor
Pharmacist Counseling Corner

P6 Extreme by Cellucor: Common Questions

Does P6 Extreme by Cellucor interact with any medications?
Yes. Based on its ingredients, P6 Extreme has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
P6 Extreme contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if P6 Extreme is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

P6 Extreme label
Go deeper

The Full Monographs Behind P6 Extreme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

P6 Extreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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