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Dietary supplement

Pantesin Pantethine Ingredients & Drug Interactions

by Swanson

Pantesin Pantethine label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pantesin Pantethine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pantesin Pantethine is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, high triglycerides, heart health support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pantesin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pantesin Pantethine by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with Pantesin Pantethine by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pantesin Pantethine by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pantesin Pantethine contains one active ingredient: pantethine, a form of the B vitamin pantothenic acid. The softgel also holds inactive ingredients including rice bran oil, gelatin, glycerin, yellow beeswax, carob extract, and soy lecithin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cardiovascular health and healthy lipid levels.
  • We looked for evidence on: Hyperlipidemia, Hyperlipoproteinemia, Hypertriglyceridemia, Cholesterol management.
  • The strongest evidence on file: Pantethine is rated "Possibly Effective" for Hyperlipoproteinemia (Natural Medicines).
  • Also on file: Pantethine is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.

The evidence for pantethine is mixed. It's possibly effective for high lipoprotein levels (hyperlipoproteinemia) — a specific type of blood fat problem.

For athletic performance, high cholesterol (hyperlipidemia), and a rare neurological condition called PKAN, we don't have enough reliable evidence to say whether it works.

The evidence, ingredient by ingredient Pantethine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pantethine is generally well tolerated in studies, though long-term safety data are limited. The most common side effects are mild gastrointestinal complaints: nausea, vomiting, diarrhea, bloating, epigastric discomfort, and flatulence.

Mild itching has been reported but is uncommon. Safety data during pregnancy aren't well established, and there isn't enough reliable information about safety during breastfeeding.

Talk with your doctor or pharmacist before using this product if you're pregnant, breastfeeding, or planning either.

Side effects, ingredient by ingredient Pantethine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pantethine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Pantesin Pantethine, check any blood thinners or antiplatelet medications you're taking — warfarin, apixaban, aspirin, clopidogrel, and similar drugs. Pantethine may increase your bleeding risk with these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pantesin Pantethine may be worth considering if you have high lipoprotein levels and your doctor supports it. If you take any blood thinner or antiplatelet medication, check with your pharmacist first — this product could raise your bleeding risk.

Most people tolerate it well, though it can cause mild stomach upset. Always talk to your pharmacist before adding it to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pantesin Pantethine, straight from the product label.

Brand Swanson
Barcode (UPC) 087614021508
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 322742
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pantesin Pantethine by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
087614021508
IngredientAmount% DV
Pantesin300 mg--

Other ingredients: Rice bran oil, Gelatin, Water, Purified, Glycerin, Yellow Beeswax, Carob Extract, Soy Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Swanson.com or call 1-800-437-4148

Formulation

Helps maintain heart-healthy lipid levels already within the normal range Helps maintain healthy circulation Supports cardiovascular health Science-backed quality since 1969

Cholesterol Support High Bioavailability

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one softgel two to three times per day with food and water.

Brand IP Statement(s)

Pantesin is a registered trademark of Dallchi Fine Chemicals, Inc.

Formula

Pantesin

Precautions

Warning: For adults only.

Consult your healthcare provider before using this or any product if you are pregnant, nursing, taking medication or have a medical condition.

Keep out of reach of children.

Do not use if seal us broken.

Contains soybeans. Contains a bioengineered food ingredient.

Storage

Store in a cool, dry place. Do not refrigerate.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pantesin Pantethine by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pantesin Pantethine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pantesin Pantethine by Swanson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Pantesin

Interacts with
122 drugs
300 mg per serving Form: Pantethine

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence i...

Pantesin monograph & interactions

Other (inactive) ingredients: Rice bran oil, Gelatin, Water, Purified, Glycerin, Yellow Beeswax, Carob Extract, Soy Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pantesin Pantethine by Swanson Drug Interactions

Want to check YOUR meds against Pantesin Pantethine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pantesin 122

Individual Drug Interactions

The ingredients in Pantesin Pantethine interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pantesin Pantethine interact with drugs. Each result below shows which ingredient is responsible. Pantesin

Each ingredient & the kinds of drugs it affects

For each ingredient in Pantesin Pantethine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pantesin1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Some evidence suggests that pantethine reduces platelet aggregation.

Likelihood Possible Evidence B
Pantesin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pantesin Pantethine, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
swanson.com
Pharmacist Counseling Corner

Pantesin Pantethine by Swanson: Common Questions

Does Pantesin Pantethine by Swanson interact with any medications?
Yes. Based on its ingredients, Pantesin Pantethine has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pantesin Pantethine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pantethine, and what's it supposed to do?
Pantethine is a form of the B vitamin pantothenic acid. The evidence shows it's possibly effective for a condition called hyperlipoproteinemia, which involves high levels of certain fats in your blood. For other uses like athletic performance or general high cholesterol, we don't have enough solid evidence yet.
What are the most common side effects?
Mild stomach complaints are the main ones: nausea, vomiting, diarrhea, bloating, discomfort in the upper abdomen, and gas. Mild itching has been reported but is uncommon. Most people tolerate pantethine well overall.
Is it safe to take during pregnancy or while breastfeeding?
Safety data during pregnancy aren't well established, and breastfeeding safety hasn't been studied enough. If you're pregnant, breastfeeding, or planning either, talk with your doctor or pharmacist before using this product — they can give you personalized advice.
Can I take this with my blood thinner?
That's the key thing to check with your pharmacist. Pantethine may increase bleeding risk when combined with blood thinners or antiplatelet drugs. Use the medication checker on this page or call us before you start.
How long has pantethine been studied for safety?
While it's generally well tolerated in the studies we have, long-term safety data are limited. That's why it's a good idea to discuss this supplement with your pharmacist, especially if you plan to take it regularly.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pantesin Pantethine is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pantesin Pantethine label
Go deeper

The Full Monographs Behind Pantesin Pantethine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantethine

Interacts with 122 drugs

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence is limited and not strong enough to repla...

Read the full Pantethine monograph →
Sources

Sources & How We Checked

Pantesin Pantethine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantethine 9 references
  1. Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
  2. Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
  3. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
  4. Agrati AM, Ambrosi G, Ferraro G, Palmieri. Gemfibrozil efficacy vs pantethine in dyslipoproteinemic patients: a controlled study. Curr Ther Res 1989;45:650-63.
  5. Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
  6. Hiramatsu, K., Nozaki, H., and Arimori, S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J.Exp.Clin.Med. 1981;6(1):49-57.
  7. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
  8. Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.
  9. Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded

See these in context on the Pantethine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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