Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Pantothenic Acid 500 mg Ingredients & Drug Interactions

by Highland Laboratories

Pantothenic Acid 500 mg label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pantothenic Acid 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Pantothenic Acid 500 mg is a dietary supplement by Highland Laboratories with 1 active ingredient. Its ingredients are commonly taken for general nutrition and energy, skin and hair health, acne (topical and oral).Based on those ingredients, 168 medications have a known interaction with it, the most serious rated major. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pantothenic Acid 500 mg by Highland Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Pantothenic Acid 500 mg by Highland Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pantothenic Acid 500 mg by Highland Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Pantothenic Acid” is listed as a grouped ingredient — the label gives one combined amount (500 mg) without saying how much of each component you get.

This supplement contains one active ingredient: calcium D-pantothenate, a form of pantothenic acid (also called vitamin B5). The inactive ingredients are calcium phosphate, cellulose, vegetable stearate, rice polish, and magnesium stearate—these help form and stabilize the tablet.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Calcium's overall clinical evidence instead.

Strong

Strong clinical evidence supports Calcium for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Hyperkalemia — rated "Effective" (Natural Medicines).
  • On file: Dyspepsia — rated "Effective" (Natural Medicines).
  • On file: Hypocalcemia — rated "Effective" (Natural Medicines).
  • On file: Kidney failure — rated "Effective" (Natural Medicines).
  • On file: Hyperparathyroidism — rated "Likely Effective" (Natural Medicines).

Our data shows calcium D-pantothenate rated as Effective for kidney failure and dyspepsia (indigestion), and Likely Effective for osteoporosis. It's also rated Effective for correcting low blood calcium (hypocalcemia) and high potassium levels (hyperkalemia).

The evidence we hold supports its use for these conditions when taken as directed.

The evidence, ingredient by ingredient Pantothenic Acid Calcium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium D-pantothenate is generally well tolerated when you take it at recommended doses. The most common side effects from taking it by mouth are belching, constipation, diarrhea, gas, and stomach upset.

Rare serious concerns from case reports include kidney stones and a skin condition called calciphylaxis. There's also some concern that very high daily doses (over 1500–2000 mg from all sources) might increase prostate cancer risk and possibly cardiovascular risk, though research on this remains mixed and criticized.

During pregnancy, adequate calcium is important; stay within recommended amounts unless your doctor advises otherwise. During breastfeeding, calcium needs can be met with recommended amounts—check with your provider about your individual needs.

One safety note rates this as Possibly Unsafe during pregnancy or lactation, so discuss your specific situation with your doctor or pharmacist.

Side effects, ingredient by ingredient Pantothenic Acid Calcium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calcium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 168 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this supplement, double-check with your pharmacist or doctor if you're on HIV integrase inhibitors (dolutegravir, elvitegravir, raltegravir), intravenous ceftriaxone, levothyroxine, sotalol, diltiazem, calcipotriene, or any heart medications. All of these have documented Major or Moderate interactions with the calcium in this product, and you'll likely need to time your doses carefully.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Pantothenic Acid 500 mg is most useful if you have low blood calcium, indigestion, high potassium, or bone health concerns—and the evidence supports those uses. Anyone taking HIV integrase inhibitors, intravenous ceftriaxone, levothyroxine, heart medications, or sotalol needs to check with their own doctor or pharmacist before adding this supplement, since timing or separation of doses will likely be needed.

High-dose calcium over the long term may carry other health risks, so talk with your provider about whether this dose and duration is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pantothenic Acid 500 mg, straight from the product label.

Brand Highland Laboratories
Barcode (UPC) 768305227101
Net contents 100 Vegetarian Tablet(s)
Market status On market
Date entered into DSLD Oct 21, 2017
DSLD ID 79460
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pantothenic Acid 500 mg by Highland Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Tablet(s)
Maximum serving Sizes:
1 Vegetarian Tablet(s)
UPC/BARCODE
768305227101
IngredientAmount% DV
Pantothenic Acid500 mg5000%
Calcium D-Pantothenate544 mg--

Other ingredients: Calcium Phosphate, Cellulose, Vegetable Stearate, Rice polish, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Pantothenic Acid 500 mg. / sol-u-tab

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Quality Assured Earth Friendly

General Statements

% Daily Value

Formulation

No corn, soy, salt, yeast, gluten, milk & egg products, sugar, starch, or preservatives.

Brand IP Statement(s)

Our tablets are processed with special plant cellulose under the Sol-U-Tab process assuring each tablet is completely solubilized within minutes of swallowing.

Suggested/Recommended/Usage/Directions

One tablet daily as a dietary supplement.

General

PR 227

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pantothenic Acid 500 mg by Highland Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pantothenic Acid 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pantothenic Acid 500 mg by Highland Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Pantothenic Acid

No known
interactions
500 mg per serving

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nea...

Pantothenic Acid monograph & interactions

Other (inactive) ingredients: Calcium Phosphate, Cellulose, Vegetable Stearate, Rice polish, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pantothenic Acid 500 mg by Highland Laboratories Drug Interactions

Want to check YOUR meds against Pantothenic Acid 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
168Drugs
7 Major 143 Moderate 18 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Pantothenic Acid 500 mg interact with 168 drugs. Click any drug to see the details.

0 of the 1 ingredient in Pantothenic Acid 500 mg interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Pantothenic Acid 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Pantothenic Acid 500 mg, from the product label.

Highland Laboratories

See all Highland Laboratories products
Name
Highland Laboratories
Pharmacist Counseling Corner

Pantothenic Acid 500 mg by Highland Laboratories: Common Questions

Does Pantothenic Acid 500 mg by Highland Laboratories interact with any medications?
Yes. Based on its ingredients, Pantothenic Acid 500 mg has a known interaction with 168 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pantothenic Acid 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this supplement actually help my weak bones?
Calcium D-pantothenate is rated Likely Effective for osteoporosis in our data, so yes—there's good evidence behind it for bone health. Just make sure you're taking the right total dose of calcium from all your sources and getting enough vitamin D to help your body use it.
What are the most common side effects?
Most people tolerate it well. The most common complaints are belching, constipation, diarrhea, gas, and stomach upset when taken by mouth. These tend to be mild and often pass.
Is it safe to take during pregnancy or while breastfeeding?
Our data shows a mixed safety picture: adequate calcium is important in pregnancy and during breastfeeding, but one safety note rates it as Possibly Unsafe in those situations. Talk with your doctor or pharmacist about what's right for you and your baby, since you need personalized guidance on dosing and timing.
Why can't I just take this at the same time as my thyroid medication?
Calcium forms insoluble compounds with levothyroxine (Synthroid) in your digestive tract, which reduces how much thyroid hormone your body absorbs. Taking them at least 4 hours apart prevents this.
Does high-dose calcium cause heart problems?
There's some concern from research that very high daily calcium—over 1500–2000 mg from all sources—might increase cardiovascular risk, but the evidence is mixed and debated. Don't exceed recommended daily amounts without talking to your doctor.
Can I take this if I'm on HIV medications?
It depends on which HIV drug you take. If you're on dolutegravir, elvitegravir, or raltegravir, calcium can significantly lower their blood levels and reduce how well they work. Talk with your HIV doctor or pharmacist—they may advise spacing doses or using a different supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pantothenic Acid 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pantothenic Acid 500 mg label
Go deeper

The Full Monographs Behind Pantothenic Acid 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantothenic Acid

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nearly all foods, and most people meet thei...

Read the full Pantothenic Acid monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph →
Sources

Sources & How We Checked

Pantothenic Acid 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 73 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantothenic Acid 11 references
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  3. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  4. Schmuth, M., Wimmer, M. A., Hofer, S., Sztankay, A., Weinlich, G., Linder, D. M., Elias, P. M., Fritsch, P. O., and Fritsch, E. Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study. Br.J.Dermatol. 2 PubMed
  5. Schreck, U., Paulsen, F., Bamberg, M., and Budach, W. Intraindividual comparison of two different skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. Creme or powder? Strahlenther.Onkol. 2002;178(6):321-329. PubMed
  6. Herbst, R. A., Uter, W., Pirker, C., Geier, J., and Frosch, P. J. Allergic and non-allergic periorbital dermatitis: patch test results of the Information Network of the Departments of Dermatology during a 5-year period. Contact Dermatitis 2004;51(1):13-1 PubMed
  7. Champault, G. and Patel, J. C. [Treatment of constipation with Bepanthene]. Med.Chir Dig. 1977;6(1):57-59.
  8. Scott LN, Fiume M, Bergfeld WF, et al. Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics. Int J Toxicol 2022;41(3_suppl):77-128. PubMed
  9. Han J, Warshaw EM. Allergic Contact Dermatitis to Panthenol in "Hypoallergenic" Products. Dermatitis 2023;34(1):62-63. PubMed
  10. Blanchard G, Kerre S, Walker A, et al. Allergic contact dermatitis from pantolactone and dexpanthenol in wound healing creams. Contact Dermatitis 2022;87(5):468-471. PubMed
  11. Peltier E, Trapp S, de Salvo R, et al. A new dexpanthenol-containing liquid cleanser for atopic-prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function. J Cosme PubMed

See these in context on the Pantothenic Acid monograph →

Calcium 62 references
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  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
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  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
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  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
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  22. Bourke JF, Mumford R, Whittaker P, et al. The effects of topical calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis. J Am Acad Dermatol 1997;37:929-34.
  23. Gueguen L, Pointillart A. The bioavailability of dietary calcium. J Am Coll Nutr 2000;19:119s-136s. PubMed
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  62. US Food and Drug Administration (FDA). Biktarvy Prescribing Information. October 2024. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/210251Orig1s020lbl.pdf. Accessed July 16, 2025.

See these in context on the Calcium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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