Papaya Fruit 4:1 Extract Powder Ingredients & Drug Interactions
by TerraVita Premium Collection
What is this page for?
First and foremost: checking Papaya Fruit 4:1 Extract Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Papaya Fruit 4:1 Extract Powder is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for digestive upset and indigestion, constipation, wound and skin care (topical).Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papaya fruit extract powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Papaya Fruit 4:1 Extract Powder by TerraVita Premium Collection
Ask about any prescription or over-the-counter medication and we check it for interactions with Papaya Fruit 4:1 Extract Powder by TerraVita Premium Collection — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Papaya Fruit 4:1 Extract Powder by TerraVita Premium Collection
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product is a single-ingredient supplement: papaya fruit extract powder in a 4:1 concentration, meaning the extract is made by reducing whole fruit. There are no other active ingredients and no inactive fillers listed.
Does it work?
Couldn't assess
The evidence for papaya extract isn't established in our data. We hold ratings of insufficient reliable evidence for its use against aging skin, hair loss (androgenic alopecia), colorectal cancer, and diabetes.
That means there isn't enough well-designed research yet to say whether it works for these purposes.
How safe is it?
Well-documented data
Ripe papaya fruit is generally well tolerated as food, but this is a concentrated supplement — and the safety data for supplement amounts is limited. The most common side effects from papaya leaf extract are nausea and vomiting.
Rare but serious reactions include severe allergic responses, and people allergic to latex may be more prone to allergic reactions to papaya because the two can cross-react. Unripe (green) papaya, papaya latex, and papaya seeds should be avoided entirely due to safety concerns.
The data also flags caution around papaya in pregnancy — some sources advise against large amounts, though the rating is mixed. Talk with your doctor or pharmacist about whether this supplement is right for you, especially if you're pregnant, breastfeeding, or have a latex allergy.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before taking this product if you use blood thinners like warfarin (Coumadin), antidiabetes drugs, amiodarone (Cordarone) for heart rhythm, or levothyroxine (Synthroid) for thyroid hormone. Papaya extract has moderate-severity interactions with all of these drug types and may reduce their effectiveness or raise their levels in dangerous ways.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This single-ingredient papaya extract may be worth considering if you're interested in its potential effects, but the evidence to support its effectiveness isn't established yet. If you take blood thinners, diabetes medications, heart rhythm drugs, or thyroid hormone, this product poses documented risks and you should not start it without checking with your own doctor or pharmacist first.
Even if you don't take those medications, talk it over with your healthcare provider before adding it to your routine.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Papaya Fruit 4:1 Extract Powder, straight from the product label.
| Brand | TerraVita Premium Collection |
|---|---|
| Barcode (UPC) | 064435210595 |
| Net contents | 4 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Apr 21, 2023 |
| DSLD ID | 289789 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Papaya Fruit 4:1 Extract Powder by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Papaya fruit extract powder | 1000 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
A Dietary Supplement
Brand IP Statement(s)
Copyright 2017 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Suggested/Recommended/Usage/Directions
Directions Stir 1/4 of a teaspoon into a glass of water and consume 3 times daily, with meals.
General Statements
TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.
Please recycle!
FDA Disclaimer Statement
Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Papaya Fruit 4:1 Extract Powder by TerraVita Premium Collection label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Papaya Fruit 4:1 Extract Powder by TerraVita Premium Collection
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.25 Teaspoon(s) Dosage formPowder Servings per container113 Amounts shown are per serving.
Papaya fruit extract powder
Interacts with92 drugs
Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...
Papaya fruit extract powder monograph & interactionsPapaya Fruit 4:1 Extract Powder by TerraVita Premium Collection Drug Interactions
HelloPharmacist Interaction Report
TerraVita Premium Collection Papaya Fruit 4:1 Extract Powder contains papaya fruit extract, which has documented interactions with several medication types.
The most serious concern is with blood thinners like warfarin (Coumadin) — papain, an enzyme in papaya extract, may increase warfarin's effects and raise your bleeding risk. A case report documented a patient whose blood-thinner levels spiked dangerously after taking a papaya supplement.
Read the full breakdown — every affected drug type, severity by severity
Other notable interactions include antidiabetes drugs (like glibenclamide), where fermented papaya may add to the blood-sugar-lowering effect, though it's unclear if this extract form carries the same risk. Amiodarone (Cordarone), a heart rhythm medication, may reach higher levels in your bloodstream when combined with papaya extract.
Levothyroxine (Synthroid), a thyroid hormone, may become less effective — one case involved a man whose thyroid function worsened after eating 5–6 whole papayas daily for two weeks.
Altogether, these interactions span 92 individual medications. Before you start this supplement, check your exact medications with the tool on this page, and confirm with your doctor or pharmacist if you take any blood thinners, diabetes medications, heart drugs, or thyroid hormone replacements.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Papaya Fruit 4:1 Extract Powder?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Papaya Fruit 4:1 Extract Powder interact with 92 drugs. Click any drug to see the details.
1 of the 1 ingredient in Papaya Fruit 4:1 Extract Powder interact with drugs. Each result below shows which ingredient is responsible. Papaya fruit extract powder
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Alogliptin, Pioglitazone interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAmiodarone (cordarone) Moderate
Interaction Summary
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Read the full Papaya Fruit Extract Powder + Amiodarone interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCanagliflozinInvokana
How Canagliflozin interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Canagliflozin, Metformin Hydrochloride interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Chlorpropamide interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Dasiglucagon Hydrochloride interactionDulaglutideTrulicity
How Dulaglutide interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Dulaglutide interactionEmpagliflozinJardiance
How Empagliflozin interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Empagliflozin, Metformin Hydrochloride interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Ertugliflozin, Metformin Hydrochloride interactionExenatideBydureon, Byetta
How Exenatide interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Exenatide Synthetic interactionGliclazideDiamicron
How Gliclazide interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Papaya Fruit 4:1 Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Extract Powder + Glipizide, Metformin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Papaya Fruit 4:1 Extract Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Papaya fruit extract powder
Amiodarone (Cordarone)
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.
Antidiabetes Drugs
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.
Levothyroxine (Synthroid, Others)
Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.
Warfarin (Coumadin)
Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Brand information
Manufacturer and brand details for Papaya Fruit 4:1 Extract Powder, from the product label.
TerraVita Premium Collection
See all TerraVita Premium Collection products- Name
- TerraVita Fine Whole Herbs
- City
- Brampton
- State
- Ontario
Papaya Fruit 4:1 Extract Powder by TerraVita Premium Collection: Common Questions
Does Papaya Fruit 4:1 Extract Powder by TerraVita Premium Collection interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is papaya extract safe to take if I'm pregnant or breastfeeding?
What are the side effects of papaya extract?
Can I take this if I have a latex allergy?
Does papaya extract actually work for diabetes or cancer prevention?
Why should I be careful about unripe papaya?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Papaya Fruit 4:1 Extract Powder is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Papaya Fruit 4:1 Extract Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Papaya Fruit 4:1 Extract Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Papaya 14 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
- Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
- Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
- Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
- Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
- Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
- Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
- Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
- Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
- Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC