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Dietary supplement

Pau D'Arco 550 mg Ingredients & Drug Interactions

by Solaray

Pau D'Arco 550 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pau D'Arco 550 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pau D'Arco 550 mg is a dietary supplement by Solaray with 1 active ingredient. Its ingredients are commonly taken for infections (bacterial, fungal, yeast), inflammation, immune support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pau d'Arco. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pau D'Arco 550 mg by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Pau D'Arco 550 mg by Solaray — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pau D'Arco 550 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pau d'arco, a tree bark extract, at 550 mg per capsule. The capsule itself is made from vegetable cellulose, and the formula also includes coconut oil, dextrin, and agave inulin as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pau D'arco product and its label doesn't state a use — see Pau D'arco's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for pau d'arco isn't established in our data. The effectiveness ratings show insufficient reliable evidence for cancer, peptic ulcers, wound healing, and dysmenorrhea—meaning the science doesn't yet support its use for these purposes.

If you're considering it for any of these reasons, talk with your doctor about what the current research actually shows.

The evidence, ingredient by ingredient Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pau d'arco is generally well tolerated at standard doses, but higher doses carry risks. The lapachol compound in pau d'arco, taken above 1.5 grams daily, may cause anemia, bleeding risk, severe nausea, vomiting, and diarrhea.

Safety data in humans is limited, so caution is warranted at higher doses. Do not use pau d'arco during pregnancy—it is possibly unsafe and may harm the developing baby.

There isn't enough safety information to use it while breastfeeding either. If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before considering this product.

Side effects, ingredient by ingredient Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pau D'arco.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product before starting if you take any blood thinners or antiplatelet drugs—including warfarin, apixaban, dabigatran, rivaroxaban, aspirin, or clopidogrel. Pau d'arco may increase bleeding risk with these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pau d'arco may appeal to someone looking for a traditional herbal remedy, but the evidence for its effectiveness isn't established in our data. The main concern is bleeding risk if you're on blood thinners or antiplatelet drugs.

It's not safe in pregnancy or while breastfeeding. Check with your own doctor or pharmacist about whether this product is right for you and your medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pau D'Arco 550 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280014402
Net contents 100 VegCap(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 296218
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pau D'Arco 550 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 VegCap(s)
Maximum serving Sizes:
1 VegCap(s)
Servings per container
100
UPC/BARCODE
076280014402
IngredientAmount% DV
Pau d'Arco550 mg--

Other ingredients: Vegetable Cellulose, Coconut Oil, Dextrin, Agave Inulin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Solaray Est. 1973

Solaray A Brighter Way 1973

Formula

True herbs

Formulation

Herbal support

Vegan

Discussion: Pau d'arco, also known as lapacho, is a flowering tree native to Brazil and other South American countries. It has been used by indigenous tribes dating back over 1,500 years and is highly valued for its overall health benefits. Pau d'arco may provide antioxidant support and has been used traditionally for normal, healthy immune system function.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Lab Verified

General Statements

Since 1973, we've scoured the globe for the highest quality ingredients, connecting you with the most efficacious supplements that help you live brighter & embrace the moments that matter most.

100% PCR Bottles

Precautions

Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product.

Keep out of reach of children.

California Residents Only Warning: Reproductive Harm - www.P65Warnings.ca.gov

Suggested/Recommended/Usage/Directions

Directions: Only as directed. Take 1 VegCap three times daily with a meal or glass of water.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pau D'Arco 550 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pau D'Arco 550 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pau D'Arco 550 mg by Solaray

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 VegCap(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Pau d'Arco

Interacts with
122 drugs
550 mg per serving Form: Tabebuia spp.

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...

Pau d'Arco monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Coconut Oil, Dextrin, Agave Inulin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pau D'Arco 550 mg by Solaray Drug Interactions

Want to check YOUR meds against Pau D'Arco 550 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pau d'Arco 122

Individual Drug Interactions

The ingredients in Pau D'Arco 550 mg interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pau D'Arco 550 mg interact with drugs. Each result below shows which ingredient is responsible. Pau d'Arco

Each ingredient & the kinds of drugs it affects

For each ingredient in Pau D'Arco 550 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pau d'Arco1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d'Arco full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pau D'Arco 550 mg, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutraceutical.com
Pharmacist Counseling Corner

Pau D'Arco 550 mg by Solaray: Common Questions

Does Pau D'Arco 550 mg by Solaray interact with any medications?
Yes. Based on its ingredients, Pau D'Arco 550 mg has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pau D'Arco 550 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. Pau d'arco is possibly unsafe during pregnancy and may harm the developing baby. There isn't enough safety data to use it while breastfeeding either. Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing.
What does pau d'arco actually do?
That's the catch—we don't have reliable evidence that pau d'arco works for cancer, peptic ulcers, wound healing, or dysmenorrhea, which are the most common reasons people take it. The science simply isn't there yet.
Are there side effects at normal doses?
At standard doses, pau d'arco is generally well tolerated. The real risks show up at higher doses (above 1.5 grams daily of the lapachol compound): anemia, bleeding risk, and severe nausea, vomiting, or diarrhea. This product is 550 mg, so you'd need to take several capsules daily to hit those danger zones—but that's something to discuss with your pharmacist.
Does this product have fillers?
Yes. Besides the pau d'arco, it contains vegetable cellulose (the capsule), coconut oil, dextrin, and agave inulin as inactive ingredients.
Why do I need to check my blood thinner medications?
Pau d'arco may reduce how your blood clots by interfering with platelet function and vitamin K. If you're already on a blood thinner like warfarin or aspirin, adding pau d'arco could raise your bleeding risk. Your pharmacist or doctor can tell you whether it's safe for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pau D'Arco 550 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pau D'Arco 550 mg label
Go deeper

The Full Monographs Behind Pau D'Arco 550 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Pau D'Arco 550 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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