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Dietary supplement

Peak Blood Flow Ingredients & Drug Interactions

by Peak Pure & Natural

Peak Blood Flow label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Peak Blood Flow against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Peak Blood Flow is a dietary supplement by Peak Pure & Natural with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Peak Blood Flow by Peak Pure & Natural

Ask about any prescription or over-the-counter medication and we check it for interactions with Peak Blood Flow by Peak Pure & Natural — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Peak Blood Flow by Peak Pure & Natural

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Peak Blood Flow contains one active ingredient: nattokinase, an enzyme derived from fermented soybeans. The capsule itself is made from vegetable material, and the formula includes inactive ingredients like maltodextrin, hydroxypropyl methylcellulose, and silica for stability and delivery.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: blood flow and circulatory health.
  • We looked for evidence on: Angina, Atherosclerosis, Cardiovascular disease (CVD), Hypertension, Hyperlipidemia, Peripheral arterial disease (PAD) — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence isn't established for nattokinase in the data we hold. Studies haven't yielded reliable evidence that it works for angina, atherosclerosis, heart disease, cancer, or chronic fatigue — effectiveness ratings for those conditions are all listed as insufficient.

If you're considering this product for a specific health goal, talk with your pharmacist or doctor about what the clinical data actually shows.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated in the short term, but its blood-thinning effect means people with bleeding risk or bleeding disorders should be cautious. The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know it's safe.

Rare cases of bleeding — including serious brain hemorrhage — have been reported, especially when nattokinase is combined with blood thinners. Some people sensitive to natto (fermented soybeans) have had allergic reactions, including anaphylaxis, within a couple of hours of taking it.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this if you're on blood thinners or antiplatelet drugs like aspirin or warfarin — nattokinase raises bleeding risk (Moderate severity). Also double-check if you take blood pressure medications, as nattokinase may lower pressure further (Moderate severity).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Peak Blood Flow may interest people looking for a supplement to support circulation, but the evidence for its effectiveness isn't established. If you take any blood thinner, antiplatelet drug, or blood pressure medication, you need to clear it with your pharmacist first — the bleeding and blood pressure risks are real.

Avoid it if you're pregnant or breastfeeding. Talk to your pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Peak Blood Flow, straight from the product label.

Brand Peak Pure & Natural
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 333603
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Peak Blood Flow by Peak Pure & Natural, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Nattokinase100 mg--

Other ingredients: Vegetable Capsule, Maltodextrin, Hydroxypropyl Methylcellulose, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Do not exceed recommended dose. Do not use if clear neck seal is broken or missing.

If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.

Warning: Consult with your health care practitioner before taking this product if you take Coumadin (Warfarin) or other blood thinners.

Storage

Store at room temperature, in a dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

100 mg Nattokinase

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Clean label V (Vegetarian) Manufactured in U.S.A. with quality ingredients from around the world

Formulation

V (Vegetarian)

Non GMO GF (Gluten free)

Suggested/Recommended/Usage/Directions

Suggested use: Adults take one (1) capsule daily, preferably with a meal, or as directed by a healthcare practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Peak Blood Flow by Peak Pure & Natural label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Peak Blood Flow label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Peak Blood Flow by Peak Pure & Natural

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Nattokinase

Interacts with
289 drugs
100 mg per serving Form: Soy

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Other (inactive) ingredients: Vegetable Capsule, Maltodextrin, Hydroxypropyl Methylcellulose, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Peak Blood Flow by Peak Pure & Natural Drug Interactions

Want to check YOUR meds against Peak Blood Flow?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289

Individual Drug Interactions

The ingredients in Peak Blood Flow interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in Peak Blood Flow interact with drugs. Each result below shows which ingredient is responsible. Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in Peak Blood Flow with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Peak Blood Flow, from the product label.

Peak Pure & Natural

See all Peak Pure & Natural products
Name
Peak Pure & Natural
Street Address
P.O. Box 24638
City
West Palm Beach
State
FL
ZipCode
33416
Phone Number
1-866-773-6899
Web Address
www.PeakNatural.com
Pharmacist Counseling Corner

Peak Blood Flow by Peak Pure & Natural: Common Questions

Does Peak Blood Flow by Peak Pure & Natural interact with any medications?
Yes. Based on its ingredients, Peak Blood Flow has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Peak Blood Flow contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Peak Blood Flow with aspirin?
Not without checking with your pharmacist first. Nattokinase has blood-thinning effects and can increase bleeding risk when combined with aspirin — there's even a case report of serious brain bleeding from that combination. Your pharmacist needs to review your exact dose and your health history.
Is nattokinase safe if I'm pregnant?
No, the safety data advises against it. There isn't enough information to know whether it's safe during pregnancy, so it's best avoided. Talk with your doctor if you're thinking about any supplement while pregnant.
What is nattokinase?
It's an enzyme that comes from natto, a Japanese fermented soybean food. It has blood-thinning properties, which is why it's marketed for circulation — but the evidence that it actually works for heart conditions isn't established in our data.
Can I take Peak Blood Flow if I have a bleeding disorder?
You should not without talking to your doctor first. Nattokinase's blood-thinning effects mean people with bleeding risk need to be cautious. Your doctor can tell you whether it's safe for your specific condition.
Does nattokinase work for heart disease?
The reliable evidence isn't there yet. The data we hold shows insufficient evidence for nattokinase in angina, atherosclerosis, and cardiovascular disease — so we can't say it works for those conditions.
Could I have an allergic reaction to Peak Blood Flow?
It's possible if you're sensitive to natto or its components. Some people have had allergic reactions ranging from throat swelling to anaphylaxis within a couple of hours of taking nattokinase. If you've never eaten natto or know you react to it, be cautious and talk to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Peak Blood Flow label
Go deeper

The Full Monographs Behind Peak Blood Flow’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Peak Blood Flow's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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