Peppermint Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Peppermint against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Peppermint is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for irritable bowel syndrome (ibs), indigestion and gas, nausea.Based on those ingredients, 796 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Peppermint dried leaf liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Peppermint by Herbal Terra
Ask about any prescription or over-the-counter medication and we check it for interactions with Peppermint by Herbal Terra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Peppermint by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Herbal Terra Peppermint contains one active ingredient: certified organic peppermint dried leaf liquid extract. The inactive ingredient is menstruum, a liquid used to extract and deliver the peppermint compounds.
This is a concentrated liquid form, not tea or food-grade peppermint.
Does it work?
Strong evidence
Peppermint is likely effective for irritable bowel syndrome (IBS). For dyspepsia (indigestion), chemotherapy-induced nausea and vomiting, barium enema-related colonic spasm, and endoscopy-associated side effects, the evidence rates it as possibly effective.
The data we hold doesn't establish effectiveness for other uses.
How safe is it?
Well-documented data
Orally, peppermint leaf and peppermint oil are generally well tolerated. The most common side effects are abdominal pain, belching, heartburn, nausea, diarrhea, dry mouth, and anal burning.
Rare but serious reactions include anaphylaxis (sudden swelling of the lips, tongue, and throat, and difficulty breathing) and allergic reactions, especially in people with a history of bronchial asthma. In large amounts, peppermint oil can cause chemical burns in the mouth and throat.
Because this is a concentrated extract, use it carefully — the safety data advises caution with concentrated supplements and recommends checking with your provider before starting. Peppermint is rated likely safe in pregnancy and during breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this peppermint extract, double-check medications your liver processes through CYP3A4, CYP2C9, and CYP2C19 enzymes — especially heart, blood pressure, and immunosuppressant drugs like cyclosporine. The CYP3A4 interaction has been seen in human studies; the others are theoretical so far but rated Moderate in concern.
Also check if you take any CYP1A2 substrates, though the Minor-rated risk for those is less established in people.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Peppermint extract is well studied for IBS and indigestion and is likely safe in pregnancy. However, because it can slow how your liver clears over 750 medications, you'll want to run your current prescriptions through the interaction checker on this page or talk it over with your pharmacist before you start.
If you take cyclosporine or any heart or blood pressure medication, that conversation is especially important.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Peppermint, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 7429524732731 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2020 |
| DSLD ID | 234106 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Organic, Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Peppermint by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| certified organic Peppermint dried leaf liquid extract | 970 mg | -- |
Other ingredients: Menstruum
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.
FDA Disclaimer Statement
Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Manufactured in the USA in an FDA registered facility
Sugar free
Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Super concentrated liquid herbal extract
Non GMO
No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free
Origin of plant material: USA.
Precautions
Caution May have contraindications.
Do not use if you are allergic to any ingredients.
Consult a physician before using during pregnancy, if nursing, or if you are on any medications.
Keep out of the reach of children.
Storage
Store in a cool, dry, dark place.
Formula
Mentha X piperita
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Made in USA Made in an FDA registered facility Natural Gluten Free
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Peppermint by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Peppermint by Herbal Terra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Certified organic Peppermint dried leaf liquid extract
Interacts with796 drugs
Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated f...
Certified organic Peppermint dried leaf liquid extract monograph & interactionsOther (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.
Peppermint by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Herbal Terra Peppermint Liquid Extract does interact with medications.
Through its peppermint leaf content, it can theoretically increase the levels of drugs your liver processes through several cytochrome P450 pathways — most notably CYP3A4, CYP2C9, and CYP2C19 substrates, plus cyclosporine (an immunosuppressant). The concern with CYP3A4 is the most established: a clinical study found that a 600 mg dose of peppermint oil inhibited this enzyme and raised blood levels of felodipine, a heart medication.
The other interactions are based on lab research so far and haven't been reported in humans yet.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 797 individual medications.
If you take any heart, blood pressure, anti-inflammatory, or immunosuppressant medications, or any drug your pharmacist tells you is processed by CYP3A4, CYP2C9, CYP2C19, or CYP1A2 enzymes, you'll want to check your exact medications with the tool on this page before starting peppermint extract. The interaction risk is rated Moderate for most of these drug types and Minor for CYP1A2 substrates, but the real-world impact depends on your specific medications and doses.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Peppermint?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Peppermint interact with 796 drugs. Click any drug to see the details.
1 of the 1 ingredient in Peppermint interact with drugs. Each result below shows which ingredient is responsible. certified organic Peppermint dried leaf liquid extract
Acetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Acetaminophen, Hydrocodone interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Acetaminophen, Ibuprofen interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAdagrasibKrazati
How Adagrasib interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Adagrasib interactionAerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C19 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionAgomelatineValdoxan
How Agomelatine interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Agomelatine interactionAlfentanilAlfenta
How Alfentanil interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Alfentanil interactionAlfuzosinUroxatral
How Alfuzosin interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Alfuzosin interactionAliskirenTekturna
How Aliskiren interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Aliskiren interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Almotriptan interactionAlogliptinNesina
How Alogliptin interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Alogliptin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Alogliptin, Pioglitazone interactionAlpelisibPiqray
How Alpelisib interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Alpelisib interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Alprazolam interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Ambrisentan interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Amiodarone interactionAmitriptylineElavil
How Amitriptyline interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C19 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 2c19 (cyp2c19) Substrates +2 Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Amitriptyline, Perphenazine interactionAmlodipineNorliqva
How Amlodipine interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Peppermint — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Peppermint Dried Leaf Liquid ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
Read the full Certified Organic Peppermint Dried Leaf Liquid Extract + Amlodipine, Celecoxib interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Peppermint with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
certified organic Peppermint dried leaf liquid extract
Cyclosporine (Neoral, Sandimmune)
Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.
Brand information
Manufacturer and brand details for Peppermint, from the product label.
Peppermint by Herbal Terra: Common Questions
Does Peppermint by Herbal Terra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to take if I'm pregnant or breastfeeding?
What are the most common side effects?
Does peppermint actually work for IBS?
Why can't I just use peppermint tea instead of this extract?
Can peppermint cause chemical burns?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Peppermint is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Peppermint’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Peppermint's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 41 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Peppermint 41 references
- Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
- Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5. PubMed
- Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8. PubMed
- Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
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