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Dietary supplement

Phyto-Gen Sea Buckthorn Bud Ingredients & Drug Interactions

by Genestra Brands

Phyto-Gen Sea Buckthorn Bud label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phyto-Gen Sea Buckthorn Bud against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phyto-Gen Sea Buckthorn Bud is a dietary supplement by Genestra Brands with 1 active ingredient. Its ingredients are commonly taken for skin health and dryness, dry eye symptoms, digestive complaints.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sea Buckthorn (Hippophae rhamnoides) bud extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phyto-Gen Sea Buckthorn Bud by Genestra Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with Phyto-Gen Sea Buckthorn Bud by Genestra Brands — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phyto-Gen Sea Buckthorn Bud by Genestra Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Phyto-Gen Sea Buckthorn Bud is a one-ingredient supplement: a liquid extract of sea buckthorn buds. The extract is suspended in a base of purified water, ethanol (alcohol), and glycerin, which help preserve it and make it easy to take by mouth.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Sea Buckthorn's overall clinical evidence instead.

Moderate

Some clinical evidence supports Sea Buckthorn for:

  • Burns Possibly Effective
Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Burns — rated "Possibly Effective" (Natural Medicines).

The evidence for sea buckthorn is mixed and incomplete. It's rated possibly effective for burns based on available research.

For eczema (atopic dermatitis), the data suggests it may not work. For other uses—lowering cholesterol (dyslipidemia), anti-aging effects on skin, and cancer prevention—there isn't enough reliable evidence to say whether it helps or not.

The evidence, ingredient by ingredient Sea Buckthorn

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sea buckthorn is generally well tolerated when eaten as a food, but the safety of supplement doses hasn't been fully studied yet. At very high doses, it can cause temporary yellow staining of the skin—one case reported yellow skin after someone took 100 grams daily for 6 months.

A small number of people using sea buckthorn topically experienced dryness, irritation, redness, or rash (rash appeared in 4% of one study group). There isn't enough reliable safety data on supplement use while breastfeeding, so use caution and talk it over with your doctor or pharmacist.

Pregnancy safety data is not on file for this ingredient.

Side effects, ingredient by ingredient Sea Buckthorn

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sea Buckthorn.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor if you're on blood thinners (including aspirin used for heart protection) or blood pressure medications. Sea buckthorn may increase bleeding risk with anticoagulants and antiplatelet drugs, and may lower blood pressure further if combined with blood pressure medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Sea buckthorn may help with burns, but evidence for other uses is weak or missing. If you take blood pressure medications or blood thinners, you'll want to check your exact drugs with your pharmacist before starting this supplement.

Even though it's a plant extract, supplement doses aren't well studied, so it's worth a conversation with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phyto-Gen Sea Buckthorn Bud, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 883196119417
Net contents 0.5 fl. Oz.; 15 mL
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 231003
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phyto-Gen Sea Buckthorn Bud by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.28 mL
Maximum serving Sizes:
0.28 mL
Servings per container
53
UPC/BARCODE
883196119417
IngredientAmount% DV
Sea Buckthorn (Hippophae rhamnoides) bud extract0.28 mL--

Other ingredients: purified Water, Ethanol, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Dose: Take 10 drops once daily or as recommended by your health professional. Invert bottle to 45 degrees and shake lightly allowing drops to fall directly into mouth or in 1/4 oz of water.

Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

This product was sealed for your protection. Do not use if box or contents are open or damaged.

Use only if safety seal is intact.

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

General Statements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our quality excellence

For warnings and additional information, see outer box.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phyto-Gen Sea Buckthorn Bud by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phyto-Gen Sea Buckthorn Bud label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phyto-Gen Sea Buckthorn Bud by Genestra Brands

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.28 mL Dosage formLiquid Servings per container53 Amounts shown are per serving.

Sea Buckthorn (Hippophae rhamnoides) bud extract

Interacts with
289 drugs
0.28 mL per serving

Sea buckthorn is a berry-bearing shrub rich in vitamins, carotenoids, and fatty acids that people use for skin, eye, digestive, and heart health. Earl...

Sea Buckthorn (Hippophae rhamnoides) bud extract monograph & interactions

Other (inactive) ingredients: Purified Water, Ethanol, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phyto-Gen Sea Buckthorn Bud by Genestra Brands Drug Interactions

Want to check YOUR meds against Phyto-Gen Sea Buckthorn Bud?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Sea Buckthorn (Hippophae rhamnoides) bud extract 289

Individual Drug Interactions

The ingredients in Phyto-Gen Sea Buckthorn Bud interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in Phyto-Gen Sea Buckthorn Bud interact with drugs. Each result below shows which ingredient is responsible. Sea Buckthorn (Hippophae rhamnoides) bud extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Phyto-Gen Sea Buckthorn Bud with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sea Buckthorn (Hippophae rhamnoides) bud extract2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that sea buckthorn fruit extracts can inhibit platelet aggregation and adhesion to collagen and fibrinogen.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.
Taking sea buckthorn appears to reduce blood pressure in some patients.

Likelihood Possible Evidence D
Sea Buckthorn (Hippophae rhamnoides) bud extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phyto-Gen Sea Buckthorn Bud, from the product label.

Genestra Brands

Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
seroyal.com
Pharmacist Counseling Corner

Phyto-Gen Sea Buckthorn Bud by Genestra Brands: Common Questions

Does Phyto-Gen Sea Buckthorn Bud by Genestra Brands interact with any medications?
Yes. Based on its ingredients, Phyto-Gen Sea Buckthorn Bud has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phyto-Gen Sea Buckthorn Bud contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will sea buckthorn actually help my skin or wounds?
Research suggests it may help with burns. For eczema, though, the evidence points to it probably not working. For anti-aging or other skin concerns, there isn't enough reliable data yet to say either way.
Can I take this with my blood pressure or blood thinner medication?
You need to check with your pharmacist or doctor first. Sea buckthorn can lower blood pressure and may increase bleeding risk, so combining it with your medications could be a problem depending on what you take and at what dose.
What are the side effects I should watch for?
At normal doses, it's usually well tolerated. At very high doses, your skin might turn yellow temporarily. If you use it on your skin, watch for dryness, redness, irritation, or rash—rash showed up in a small number of people in one study.
Is it safe to take while I'm breastfeeding?
There isn't enough reliable safety data on supplement doses for breastfeeding, so use caution. Talk with your doctor or pharmacist about whether it's right for you in this situation.
What's actually in this liquid?
It's one active ingredient—sea buckthorn bud extract—mixed with water, ethanol (alcohol), and glycerin to preserve and stabilize it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phyto-Gen Sea Buckthorn Bud is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phyto-Gen Sea Buckthorn Bud label
Go deeper

The Full Monographs Behind Phyto-Gen Sea Buckthorn Bud’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sea Buckthorn

Interacts with 289 drugs

Sea buckthorn is a berry-bearing shrub rich in vitamins, carotenoids, and fatty acids that people use for skin, eye, digestive, and heart health. Early research is promising for a few uses l...

Read the full Sea Buckthorn monograph →
Sources

Sources & How We Checked

Phyto-Gen Sea Buckthorn Bud's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sea Buckthorn 7 references
  1. Johansson AK, Korte H, Yang B, et al. Sea buckthorn berry oil inhibits platelet aggregation. J Nutr Biochem 2000;11:491-5.. PubMed
  2. Grad, S. C., Muresan, I., and Dumitrascu, D. L. Generalized yellow skin caused by high intake of sea buckthorn. Forsch.Komplementmed. 2012;19(3):153-156. PubMed
  3. Vlasov, V. V. [Hippophae oil in the treatment of superficial skin burns]. Vestn.Dermatol Venerol. 1970;44(6):69-72.
  4. Chang BB, Wang F Xu TY Zhang QQ He J Zhang XJ Li J. Total flavones of Hippophae rhamnoides L. for essential hypertension: a systematic review of randomized controlled trials. Chinese Journal of Evidence-Based Medicine. 2009;9(11):1207-1213. DOI
  5. Olas B, Kontek B, Szczesna M, et al. Inhibition of blood platelet adhesion by phenolics rich fraction of Hippophae rhamnoides L. fruits. J Physiol Pharmacol. 2017;68(2):223-9.
  6. Larmo P, Järvinen R, Laihia J, et al. Effects of a sea buckthorn oil spray emulsion on dry eye. Cont Lens Anterior Eye. 2019;42(4):428-433. PubMed
  7. De Seta F, Caruso S, Di Lorenzo G, Romano F, Mirandola M, Nappi RE. Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study. Ma PubMed

See these in context on the Sea Buckthorn monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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