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Dietary supplement

TestoPlex Plus Ingredients & Drug Interactions

by XYMOGEN

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

TestoPlex Plus is a dietary supplement by XYMOGEN with 2 active ingredients. Its ingredients are commonly taken for fatigue and low energy, male fertility and testosterone support, general vitality and aging.Based on those ingredients, 333 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are LJ100, PrimaVie. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of TestoPlex Plus by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

TestoPlex Plus contains 2 active ingredients. PrimaVie is a purified form of shilajit, a mineral-rich compound traditionally used in ayurvedic medicine.

LJ100 is eurycoma longifolia (also called Tongkat Ali), an herbal extract from the roots of the plant. The product also includes several inactive ingredients — hypromellose, microcrystalline cellulose, dicalcium phosphate dihydrate, ascorbyl palmitate (a form of vitamin C), silica, and water — which serve as capsule material, binders, and preservatives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support vitality and physical mental well-being.
  • We looked for evidence on: Age-related testosterone deficiency, Athletic performance, Muscle strength, Male Infertility, Sexual desire, Sexual dysfunction — and 4 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Muscle strength, Age-related testosterone deficiency, Male Infertility.

The evidence for what these ingredients actually do is mixed and limited. For eurycoma longifolia, sexual desire is rated possibly effective — some studies support its use for that purpose.

However, athletic performance is rated possibly ineffective. For shilajit (PrimaVie), we don't have enough reliable evidence to rate it for sexual dysfunction, athletic performance, Alzheimer disease, benign prostatic hyperplasia, or osteopenia.

Neither ingredient has solid proof it works for the conditions this product implies it treats, so talk with your pharmacist about what the research actually shows for your specific goal.

The evidence, ingredient by ingredient Shilajit Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Shilajit is generally well tolerated, but there's an important caveat: unpurified products may contain heavy metals or contaminants, so stick with purified, tested brands only — XYMOGEN products are typically third-party tested, which is good. Eurycoma longifolia is also generally well tolerated in short-term studies, though long-term safety is uncertain.

The main rare side effects documented are allergy (including a reported case of anaphylaxis) and headache with shilajit. Because eurycoma longifolia may raise testosterone, there's a theoretical risk of testosterone-related side effects — acne, insulin resistance, liver stress — if your levels climb too high.

During pregnancy, shilajit should be avoided due to contamination risk and insufficient safety data; a case report links it to severe high blood pressure (mineralocorticoid-excess syndrome) in one pregnant woman. Eurycoma longifolia should also be avoided in pregnancy because of insufficient data and possible hormonal effects.

While breastfeeding, safety data for shilajit is unknown, so avoid it; eurycoma longifolia has no reliable safety information either, so it's best avoided as well.

Side effects, ingredient by ingredient Shilajit Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Eurycoma Longifolia, Shilajit.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 333 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take TestoPlex Plus, check with your pharmacist if you're on antidiabetes drugs (like metformin or glibenclamide) — shilajit may lower your blood sugar further. Also flag propranolol (Inderal) or other beta-blockers, since eurycoma longifolia can weaken their effect.

Less commonly, if you take drugs metabolized by CYP1A2, CYP2C19, or CYP2A6 enzymes, or if you're on testosterone therapy, mention this product as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

TestoPlex Plus is most relevant if you're interested in sexual function support and willing to accept that evidence is sparse. If you take diabetes medication or propranolol, you need to talk with your pharmacist before starting this product — the interactions are real and could affect how your drugs work.

Avoid it entirely during pregnancy or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TestoPlex Plus, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 871149002121
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 303854
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TestoPlex Plus by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
871149002121
IngredientAmount% DV
PrimaVie500 mg--
LJ100200 mg--

Other ingredients: Hypromellose, Water, Microcrystalline Cellulose, Dicalcium Phosphate Dihydrate, Ascorbyl Palmitate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take two capsules in the morning, or as directed by your healthcare professional.

Precautions

Consult your healthcare professional prior to use.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Do not use if tamper seal is damaged. The labeling on this product does not comply with California's Proposition 65. Therefore, this product may not be sold in California.

Storage: Keep closed in a cool, dry place out of reach of children.

Formulation

TestoPlex Plus features two safe, clinically-tested, standardized, and patented ingredients designed to support vitality and general physical and mental well-being in men and women. Numerous studies have demonstrated that PrimaVie shilajit and LJ100 Eurycoma longifolia support healthy androgen biosynthesis, which includes modulating the influence of sex hormone-binding globulin.

Formulated to exclude: Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, or artificial sweeteners.

Supports Vitality, Virility, and Vigor

Vegetarian Caps

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Storage: Keep closed in a cool, dry place out of reach of children.

Brand IP Statement(s)

S1. PrimaVie is a registered trademark of Natreon, Inc. and is protected under U.S. patents 6,969,612 and 6,440,712. S2. LJ100 is a registered trademark of HP ingredients. Bioactive Fraction of Eurycoma Longifolia is protected by Worldwide patent WO/02/17946 A1 and U.S. patent 7,132,117. Copyright 2023 XYMOGEN

XYMOGEN Exclusive Professional Formulas

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

ePV (ePedigree Verification) Vegetarian Caps Third-Party GMP Compliant Verified

General Statements

Scan to Learn more! This package is completely recyclable

Formula

Numerous studies have demonstrated that PrimaVie shilajit and LJ100 Eurycoma longifolia support healthy androgen biosynthesis, which includes modulating the influence of sex hormone-binding globulin.

See for yourself

TestoPlex Plus by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in TestoPlex Plus by XYMOGEN

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

PrimaVie

Interacts with
86 drugs
500 mg per serving Form: Shilajit

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and v...

PrimaVie monograph & interactions

LJ100

Interacts with
248 drugs
200 mg per serving Form: Eurycoma longifolia Root Extract

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

LJ100 monograph & interactions

Other (inactive) ingredients: Hypromellose, Water, Microcrystalline Cellulose, Dicalcium Phosphate Dihydrate, Ascorbyl Palmitate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

TestoPlex Plus by XYMOGEN Drug Interactions

Want to check YOUR meds against TestoPlex Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
333Drugs
89 Moderate 244 Minor

Ingredients driving the most interactions

LJ100 248

Each ingredient & the kinds of drugs it affects

For each ingredient in TestoPlex Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

LJ1005 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D

PrimaVie1 drug type · 86 drugs

Antidiabetes Drugs

Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Most human and animal research shows that shilajit can decrease fasting plasma glucose levels. In an animal model, shilajit 100 mg per kg daily enhanced the glucose-lowering ability of both glibenclamide and metformin when given in combination over a 4 week period. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for TestoPlex Plus, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

TestoPlex Plus by XYMOGEN: Common Questions

Does TestoPlex Plus by XYMOGEN interact with any medications?
Yes. Based on its ingredients, TestoPlex Plus has a known interaction with 333 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TestoPlex Plus contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant or breastfeeding?
No. Both active ingredients should be avoided during pregnancy — shilajit due to contamination risk and lack of safety data, and eurycoma longifolia due to insufficient data and possible hormonal effects. While breastfeeding, safety is unknown for both, so it's best to avoid this product. Talk with your doctor or pharmacist about your individual situation.
What is shilajit (PrimaVie), and why is purity important?
Shilajit is a mineral-rich substance used in traditional medicine. The safety caution here is that unpurified shilajit can contain heavy metals or other contaminants, so you should only use purified, tested products like those XYMOGEN makes. If you see a shilajit product without purity certification, skip it.
Can this product actually help with sexual function?
Eurycoma longifolia (LJ100) is rated possibly effective for sexual desire based on some research, so there's some evidence. Shilajit, however, has insufficient reliable evidence for sexual dysfunction — meaning we don't have enough studies to know whether it works. Your mileage may vary.
I take metformin for diabetes. Can I use TestoPlex Plus?
You need to talk with your pharmacist before starting this product. Shilajit can enhance the blood-sugar-lowering effect of metformin, which means your blood sugar could drop lower than expected — that's a moderate-severity interaction. Your dosing might need adjustment, or this product might not be right for you.
What are the most common side effects?
Most people tolerate these ingredients well in short-term use. Headache is reported rarely with shilajit. Eurycoma longifolia is generally well tolerated, but if it raises your testosterone too much, you could theoretically experience acne, insulin resistance, or liver stress. Allergy is rare but serious — one case progressed to anaphylaxis.
Do I need to worry about heavy metals in this product?
Shilajit can pick up heavy metals or contaminants if it isn't purified. XYMOGEN uses PrimaVie, which is a purified, standardized form, so the product should be safe on that front. Just make sure you're buying the genuine XYMOGEN version, not a cheaper unpurified alternative.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TestoPlex Plus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TestoPlex Plus label
Sources

Sources & How We Checked

TestoPlex Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Shilajit 8 references
  1. Sadeghi SMH, Hosseini Khameneh SM, Khodadoost M, et al. Efficacy of momiai in tibia fracture repair: A randomized double-blinded placebo-controlled clinical trial. J Altern Complement Med 2020;26(6):521-528.
  2. Losa F, Deidda M, Firinu D, Martino MLD, Barca MP, Giacco SD. Exercise-induced anaphylaxis with an Ayurvedic drug as cofactor: A case report. World J Clin Cases 2019;7(5):623-627. PubMed
  3. Biswas TK, Pandit S, Mondal S, et al. Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. Andrologia 2010;42(1):48-56. PubMed
  4. Stavropoulos K, Sotiriadis A, Patoulias D, et al. Pseudohyperaldosteronism due to mumijo consumption during pregnancy: a licorice-like syndrome. Gynecol Endocrinol 2018;34(12):1019-1021. PubMed
  5. Ghezelbash B, Shahrokhi N, Khaksari M, Ghaderi-Pakdel F, Asadikaram G. Hepatoprotective effects of shilajit on high fat-diet induced non-alcoholic fatty liver disease (NAFLD) in rats. Horm Mol Biol Clin Investig 2020;41(1):/j/hmbci. PubMed
  6. Ghezelbash B, Shahrokhi N, Khaksari M, Asadikaram G, Shahrokhi M, Shirazpour S. Protective roles of shilajit in modulating resistin, adiponectin, and cytokines in rats with non-alcoholic fatty liver disease. Chin J Integr Med 2022;28(6):531-537. PubMed
  7. Jafari M, Forootanfar H, Ameri A, et al. Antioxidant, cytotoxic and hyperalgesia-suppressing activity of a native Shilajit obtained from Bahr Aseman mountains. Pak J Pharm Sci 2019;32(5):2167-2173. DOI
  8. Trivedi NA, Mazumdar B, Bhatt JD, Hemavathi KG. Effect of shilajit on blood glucose and lipid profile in alloxan-induced diabetic rats. Ind. J. Pharmacol. 2004; 36(6):373-376.

See these in context on the Shilajit monograph →

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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