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Dietary supplement

Phyto-Gen Vrl-gen Ingredients & Drug Interactions

by Genestra Brands

Phyto-Gen Vrl-gen label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phyto-Gen Vrl-gen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phyto-Gen Vrl-gen is a dietary supplement by Genestra Brands with 3 active ingredients. Its ingredients are commonly taken for dry eyes and eye strain, joint pain and inflammation, immune and general wellness support.Based on those ingredients, 309 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sea Buckthorn (Hippophae rhamnoides) bud extract, Black Currant (Ribes nigrum) bud extract, Black Alder (Alnus glutinosa) bud extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phyto-Gen Vrl-gen by Genestra Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with Phyto-Gen Vrl-gen by Genestra Brands — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phyto-Gen Vrl-gen by Genestra Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Phyto-Gen Vrl-gen contains 3 active ingredients in liquid form: black currant bud extract, black alder bud extract, and sea buckthorn bud extract. These are all plant-derived extracts intended to provide concentrated compounds from the buds of their respective plants.

The liquid also contains inactive ingredients — purified water, ethanol, and glycerin — which serve as the base and preservative.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

  • Burns via Sea Buckthorn Possibly Effective
Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Burns — rated "Possibly Effective" (Sea Buckthorn) (Natural Medicines).

The evidence for what this product does is mixed and limited. Sea buckthorn shows possibly effective support for burns, though it's rated possibly ineffective for eczema.

Black currant and black alder have insufficient reliable evidence for the conditions listed in our data — including Alzheimer disease, liver disease, common cold, cough, and eczema. Sea buckthorn also lacks solid evidence for dyslipidemia (high cholesterol), aging skin, and cancer.

If you're considering this supplement for a specific condition, talk with your doctor or pharmacist about whether the evidence supports its use.

The evidence, ingredient by ingredient Black Currant Black Alder Sea Buckthorn

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Black currant is generally well tolerated as a food, but concentrated supplements are less studied — use cautiously. In a large trial of black currant seed oil, a small number of participants taking 1.8 grams twice daily reported mild diarrhea 2–10 days after starting.

Black alder has limited safety data and may cause nausea or stomach upset; the facts advise against its use during pregnancy and note that breastfeeding safety is unknown. Sea buckthorn is generally well tolerated as a food, but supplement safety has not been fully studied, and high doses may cause yellow staining of the skin (one reported case involved 100 grams daily for 6 months).

Topical sea buckthorn oil has been associated with dryness, irritation, redness, and rash in about 4% of trial participants.

Side effects, ingredient by ingredient Black Currant Black Alder Sea Buckthorn

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Black Alder, Sea Buckthorn, Black Currant.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 309 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking Phyto-Gen Vrl-gen if you're on blood thinners or antiplatelet drugs (like warfarin or aspirin), blood pressure medications, phenothiazine antipsychotics, or the chemotherapy drugs cisplatin or doxorubicin. Moderate-severity interactions are documented for all these drug types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Phyto-Gen Vrl-gen is a three-herb liquid supplement with limited evidence for most of its intended uses and significant interactions with blood thinners, heart and blood pressure medications, certain antipsychotics, and chemotherapy drugs. If you take any prescription medication — especially for bleeding, heart, blood pressure, mental health, or cancer — check with your doctor or pharmacist before starting this product.

Pregnant women should avoid black alder; others should discuss concentrated herbal supplements with their own healthcare provider before use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phyto-Gen Vrl-gen, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 883196117215
Net contents 0.5 fl. Oz.; 15 mL
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 230897
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phyto-Gen Vrl-gen by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.28 mL
Maximum serving Sizes:
0.28 mL
Servings per container
53
UPC/BARCODE
883196117215
IngredientAmount% DV
Black Currant (Ribes nigrum) bud extract0.09 mL--
Black Alder (Alnus glutinosa) bud extract0.09 mL--
Sea Buckthorn (Hippophae rhamnoides) bud extract0.09 mL--

Other ingredients: purified Water, Ethanol, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Dose: Take 10 drops once daily or as recommended by your health professional. Invert bottle to 45 degrees and shake lightly allowing drops to fall directly into mouth or in 1/4 oz of water.

General Statements

For warnings and additional information, see outer box.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Scan to learn about our quality excellence

Precautions

Keep out of the reach of children.

Use only if safety seal is intact.

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

This product was sealed for your protection. Do not use if box or contents are open or damaged.

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Formula

Black Currant Sea Buckthorn Black Alder

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phyto-Gen Vrl-gen by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phyto-Gen Vrl-gen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phyto-Gen Vrl-gen by Genestra Brands

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.28 mL Dosage formLiquid Servings per container53 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Black Currant (Ribes nigrum) bud extract

Interacts with
140 drugs
0.09 mL per serving

Black currant is a nutritious berry that is rich in vitamin C and antioxidants, and its seed oil contains the omega-6 fatty acid GLA. While it is enjo...

Black Currant (Ribes nigrum) bud extract monograph & interactions

Black Alder (Alnus glutinosa) bud extract

Interacts with
2 drugs
0.09 mL per serving

Black Alder is a European tree whose bark and leaves have a long history in folk medicine, mainly as an astringent gargle or wound wash. There is very...

Black Alder (Alnus glutinosa) bud extract monograph & interactions

Sea Buckthorn (Hippophae rhamnoides) bud extract

Interacts with
289 drugs
0.09 mL per serving

Sea buckthorn is a berry-bearing shrub rich in vitamins, carotenoids, and fatty acids that people use for skin, eye, digestive, and heart health. Earl...

Sea Buckthorn (Hippophae rhamnoides) bud extract monograph & interactions

Other (inactive) ingredients: Purified Water, Ethanol, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phyto-Gen Vrl-gen by Genestra Brands Drug Interactions

Want to check YOUR meds against Phyto-Gen Vrl-gen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
309Drugs
309 Moderate

Ingredients driving the most interactions

Sea Buckthorn (Hippophae rhamnoides) bud extract 289
Black Currant (Ribes nigrum) bud extract 140
Black Alder (Alnus glutinosa) bud extract 2

Individual Drug Interactions

The ingredients in Phyto-Gen Vrl-gen interact with 309 drugs. Click any drug to see the details.

3 of the 3 ingredients in Phyto-Gen Vrl-gen interact with drugs. Each result below shows which ingredient is responsible. Sea Buckthorn (Hippophae rhamnoides) bud extract Black Currant (Ribes nigrum) bud extract Black Alder (Alnus glutinosa) bud extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Phyto-Gen Vrl-gen with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sea Buckthorn (Hippophae rhamnoides) bud extract2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that sea buckthorn fruit extracts can inhibit platelet aggregation and adhesion to collagen and fibrinogen.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.
Taking sea buckthorn appears to reduce blood pressure in some patients.

Likelihood Possible Evidence D
Sea Buckthorn (Hippophae rhamnoides) bud extract full monograph & interactions

Black Currant (Ribes nigrum) bud extract2 drug types · 140 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black currant seed oil might increase the risk of bleeding if used in combination with anticoagulant or antiplatelet drugs.
Gamma-linolenic acid (GLA), a constituent of black currant seed oil, appears to have antiplatelet effects.

Likelihood Possible Evidence D
Phenothiazines

Theoretically, black currant seed oil might increase the risk of seizure in patients receiving phenothiazines.
Black currant seed oil contains gamma-linolenic acid (GLA). There is some concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines, although there is no evidence that black currant seed oil causes seizures. In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with GLA, although none experienced an actual seizure. In another report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose 4 grams daily, which contains GLA, was added. One of these patients had a prior history of seizures.

Likelihood Possible Evidence D
Black Currant (Ribes nigrum) bud extract full monograph & interactions

Black Alder (Alnus glutinosa) bud extract2 drug types · 2 drugs

Cisplatin (Platinol-Aq)

Laboratory research shows that black alder bark extracts can antagonize the chemotherapeutic effects of cisplatin. This interaction has not been evaluated in humans. Until more is known, use this combination with caution.

Likelihood Possible Evidence D
Doxorubicin (Adriamycin, Others)

Laboratory research shows that black alder bark extracts can antagonize the chemotherapeutic effects of doxorubicin. This interaction has not been evaluated in humans. Until more is known, use this combination with caution.

Likelihood Possible Evidence D
Black Alder (Alnus glutinosa) bud extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phyto-Gen Vrl-gen, from the product label.

Genestra Brands

Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
seroyal.com
Pharmacist Counseling Corner

Phyto-Gen Vrl-gen by Genestra Brands: Common Questions

Does Phyto-Gen Vrl-gen by Genestra Brands interact with any medications?
Yes. Based on its ingredients, Phyto-Gen Vrl-gen has a known interaction with 309 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phyto-Gen Vrl-gen contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data for concentrated supplements of these herbs in pregnancy and breastfeeding is insufficient. Black alder should be avoided during pregnancy, and its safety while breastfeeding is unknown. There isn't enough data on the other two ingredients in these conditions either. Talk with your doctor or pharmacist for personalized advice before taking Phyto-Gen Vrl-gen.
What side effects have been reported?
Black currant has caused mild diarrhea in a small number of people taking high doses. Sea buckthorn at very high doses (100 grams daily for months) has been linked to yellow skin staining, and topical sea buckthorn oil has caused dryness, rash, irritation, and redness in some users. Black alder may cause nausea or stomach upset.
Does this product actually work for anything?
Sea buckthorn shows possibly effective evidence for burns, but it's possibly ineffective for eczema. Black currant and black alder have insufficient evidence for the conditions in our data — meaning we don't have solid proof they work for those uses. If you're buying this for a specific reason, check with your pharmacist about what the science actually supports.
Is this safe to use with my medications?
Not without checking first. This product interacts with blood thinners, blood pressure medications, certain antipsychotics, and chemotherapy drugs. Use the interaction checker on this page with your full medication list, then confirm the results with your doctor or pharmacist before you start.
Why is the form a liquid and not a capsule?
This product contains plant bud extracts suspended in a liquid base of water, ethanol, and glycerin. The liquid form allows the extracts to stay blended and preserved. It's a different delivery method than tablets or capsules, but both can work — it depends on the ingredients and how the maker chose to formulate it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phyto-Gen Vrl-gen label
Go deeper

The Full Monographs Behind Phyto-Gen Vrl-gen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Currant

Interacts with 140 drugs

Black currant is a nutritious berry that is rich in vitamin C and antioxidants, and its seed oil contains the omega-6 fatty acid GLA. While it is enjoyed safely as a food and is popular as a...

Read the full Black Currant monograph → Herb & supplement monograph

Black Alder

Interacts with 2 drugs

Black Alder is a European tree whose bark and leaves have a long history in folk medicine, mainly as an astringent gargle or wound wash. There is very little modern human research to confirm...

Read the full Black Alder monograph → Herb & supplement monograph

Sea Buckthorn

Interacts with 289 drugs

Sea buckthorn is a berry-bearing shrub rich in vitamins, carotenoids, and fatty acids that people use for skin, eye, digestive, and heart health. Early research is promising for a few uses l...

Read the full Sea Buckthorn monograph →
Sources

Sources & How We Checked

Phyto-Gen Vrl-gen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Currant 6 references
  1. Guivernau M, Meza N, Barja P, Roman O. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Prostaglandins Leukot Essent Fatty A PubMed
  2. Fa-lin Z, Zhen-yu W, Yan H, et al. Efficacy of blackcurrant oil soft capsule, a Chinese herbal drug, in hyperlipidemia treatment. Phytother Res 2010;24 Suppl 2:S209-13. PubMed
  3. Holman CP and Bell AF. A trial of evening primrose oil in the treatment of chronic schizophrenia. J Orhtomolecular Psych 1983;12:302-304.
  4. Vaddadi KS. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Prostaglandins Med 1981;6(4):375-379. PubMed
  5. Norred, C. L. and Brinker, F. Potential coagulation effects of preoperative complementary and alternative medicines. Alt Ther 2001;7(6):58-67.
  6. Puri BK. The safety of evening primrose oil in epilepsy. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. PubMed

See these in context on the Black Currant monograph →

Black Alder 1 reference
  1. Dinic J, Novakovic M, Podolski-Renic A, et al. Antioxidative activity of diarylheptanoids from the bark of black alder (Alnus glutinosa) and their interaction with anticancer drugs. Planta Med 2014;80(13):1088-96. doi: 10.1055/s-0034-1382993. Epub 2014 Au PubMed

See these in context on the Black Alder monograph →

Sea Buckthorn 7 references
  1. Johansson AK, Korte H, Yang B, et al. Sea buckthorn berry oil inhibits platelet aggregation. J Nutr Biochem 2000;11:491-5.. PubMed
  2. Grad, S. C., Muresan, I., and Dumitrascu, D. L. Generalized yellow skin caused by high intake of sea buckthorn. Forsch.Komplementmed. 2012;19(3):153-156. PubMed
  3. Vlasov, V. V. [Hippophae oil in the treatment of superficial skin burns]. Vestn.Dermatol Venerol. 1970;44(6):69-72.
  4. Chang BB, Wang F Xu TY Zhang QQ He J Zhang XJ Li J. Total flavones of Hippophae rhamnoides L. for essential hypertension: a systematic review of randomized controlled trials. Chinese Journal of Evidence-Based Medicine. 2009;9(11):1207-1213. DOI
  5. Olas B, Kontek B, Szczesna M, et al. Inhibition of blood platelet adhesion by phenolics rich fraction of Hippophae rhamnoides L. fruits. J Physiol Pharmacol. 2017;68(2):223-9.
  6. Larmo P, Järvinen R, Laihia J, et al. Effects of a sea buckthorn oil spray emulsion on dry eye. Cont Lens Anterior Eye. 2019;42(4):428-433. PubMed
  7. De Seta F, Caruso S, Di Lorenzo G, Romano F, Mirandola M, Nappi RE. Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study. Ma PubMed

See these in context on the Sea Buckthorn monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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