Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

PMA Positive Mental Attitude Ingredients & Drug Interactions

by Viva Vitamins

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

PMA Positive Mental Attitude is a dietary supplement by Viva Vitamins with 4 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 440 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are GABA, L-Glutamine, L-Tyrosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of PMA Positive Mental Attitude by Viva Vitamins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

PMA Positive Mental Attitude contains four active ingredients. L-Glutamine is an amino acid used to support recovery from illness and physical stress.

GABA (gamma-aminobutyric acid) is a neurotransmitter your brain uses to promote relaxation. L-Tyrosine is another amino acid that supports brain function and mood.

The product also contains DL-Phenylalanine, which we cannot verify for you. The capsule itself is made from vegetable cellulose.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: mental alertness, focus, mood, and motivation.
  • We looked for evidence on: Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Depression, Fatigue, Memory, Psychological well-being — and 4 related terms.
  • The strongest evidence on file: Tyrosine is rated "Possibly Effective" for Cognitive function (Natural Medicines).
  • Also on file: Tyrosine is rated "Possibly Effective" for Memory.
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Depression, Post-traumatic stress disorder (PTSD), Psychological well-being.

The evidence behind these ingredients is mixed. L-Glutamine is effective for sickle cell disease and shows possible benefit for muscle wasting in HIV/AIDS, recovery after surgery, and critical illness from trauma.

L-Tyrosine is effective for phenylketonuria (PKU) and possibly effective for focus and memory — though it appears ineffective for athletic performance. GABA has insufficient evidence for the conditions it's marketed for, including anxiety, ADHD, and athletic performance.

We hold no effectiveness data for DL-Phenylalanine.

The evidence, ingredient by ingredient Glutamine Gamma-aminobutyric Acid (gaba) Tyrosine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glutamine and L-Tyrosine are generally well tolerated in healthy adults, though people with kidney or liver disease should use L-Glutamine only under medical supervision. Common side effects from L-Glutamine include bloating, constipation, diarrhea, nausea, and headache.

L-Tyrosine may cause fatigue, headache, heartburn, and nausea, especially at higher doses. GABA is often tolerated short-term, but long-term safety isn't well studied.

It may cause drowsiness, nausea, muscle weakness, and minor throat irritation. Rare cases of mania have been reported with high-dose glutamine in people with bipolar disorder.

Side effects, ingredient by ingredient Glutamine Gamma-aminobutyric Acid (gaba) Tyrosine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Gamma-aminobutyric Acid (gaba), Glutamine, Tyrosine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications; Parkinson's medications.
  • For scale: 440 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use anticonvulsant medications (seizure drugs), antihypertensive drugs (blood pressure medications), levodopa (Parkinson's medication), thyroid hormone medications, or CNS depressants (sedatives, sleep aids, anxiety medications). L-Tyrosine and levodopa doses should be separated by at least 2 hours if you take both.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to someone looking for a brain-support blend, but the evidence for most of its ingredients is thin or absent. If you take anticonvulsants, blood pressure medications, Parkinson's medication, thyroid hormone, or any sedating drugs, you'll want to discuss this product with your doctor or pharmacist first — the interaction risks are real, even if some haven't been seen in humans yet.

People with kidney, liver, or bipolar disorder should talk to their healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PMA Positive Mental Attitude, straight from the product label.

Brand Viva Vitamins
Barcode (UPC) 812720016342
Net contents 120 Veggie Cap(s)
Market status On market
Date entered into DSLD Oct 23, 2020
DSLD ID 238864
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PMA Positive Mental Attitude by Viva Vitamins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Cap(s)
Maximum serving Sizes:
1 Veggie Cap(s)
Servings per container
120
UPC/BARCODE
812720016342
IngredientAmount% DV
L-Glutamine100 mg--
GABA100 mg--
L-Tyrosine200 mg--
DL-Phenylalanine250 mg--

Other ingredients: Vegetable Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Direction: As a dietary supplement, take one or more capsules daily, on an empty stomach, or as directed by your health care practitioner.

Formulation

Viva's PMA assists in the maintenance of mental alertness and acuity, while helping to promote motivation, a positive mood, and the ability to focus. The neurotransmitters in our bodies are produced from amino acid building blocks, primarily L-Tyrosine and DL-Phenylalanine. Viva has combined these amino acids with L-glutamine and GABA to help foster proper brain function and mental activity. So be positive with Viva's PMA.

Promotes mental performance Assists feelings of well-being

Contains No: Gluten, sugar, salt, starch, yeast, corn, soy, wheat, lactose, citrus, milk, egg, fish products, artificial coloring, flavoring, or preservatives added.

Made in the USA

Non-GMO

Manufactured in an NSF - GMP Certified facility

Storage

Store in a cool, dry place. Do not refrigerate.

General Statements

Please recycle.

We always use the highest quality ingredients Premium formulas

For more information, visit www.vivavitamins.com

In God we trust

Precautions

Keep out of the reach of children.

Do not use if safety seal under cap is broken or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

2017 Manufactured exclusively for Viva Vitamins

See for yourself

PMA Positive Mental Attitude by Viva Vitamins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in PMA Positive Mental Attitude by Viva Vitamins

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veggie Cap(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
100 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

GABA

Interacts with
419 drugs
100 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

GABA monograph & interactions

L-Tyrosine

Interacts with
21 drugs
200 mg per serving

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...

L-Tyrosine monograph & interactions

DL-Phenylalanine

250 mg per serving

Other (inactive) ingredients: Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

PMA Positive Mental Attitude by Viva Vitamins Drug Interactions

Want to check YOUR meds against PMA Positive Mental Attitude?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
440Drugs
242 Moderate 198 Minor

Ingredients driving the most interactions

GABA 419

Each ingredient & the kinds of drugs it affects

For each ingredient in PMA Positive Mental Attitude with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

GABA2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for PMA Positive Mental Attitude, from the product label.

Viva Vitamins

Name
Viva Vitamins
City
Santa Clarita
State
CA
ZipCode
91355
Web Address
www.vivavitamins.com
Pharmacist Counseling Corner

PMA Positive Mental Attitude by Viva Vitamins: Common Questions

Does PMA Positive Mental Attitude by Viva Vitamins interact with any medications?
Yes. Based on its ingredients, PMA Positive Mental Attitude has a known interaction with 440 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PMA Positive Mental Attitude contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-Glutamine safe if I have kidney disease?
No — if you have kidney or liver disease, you should only use L-Glutamine under close medical supervision. Talk to your doctor before starting this product.
Can I take this while pregnant or breastfeeding?
L-Glutamine is rated likely safe in pregnancy. However, there isn't enough safety data for GABA and L-Tyrosine during pregnancy, and GABA should be avoided while breastfeeding. There's insufficient data for L-Tyrosine while breastfeeding. Talk to your doctor or pharmacist about whether this product is right for you.
Will this actually help my anxiety?
The evidence for GABA to treat anxiety is insufficient — we don't have reliable data showing it works. Your best bet is to discuss anxiety management with your doctor or pharmacist.
What are the most common side effects?
From L-Glutamine you might experience bloating, constipation, diarrhea, nausea, or headache. L-Tyrosine may cause fatigue, headache, heartburn, or nausea. GABA may cause drowsiness, nausea, or muscle weakness.
Can I take this long-term?
L-Glutamine and L-Tyrosine are generally well tolerated, though you should check with your doctor before regular use. GABA's long-term safety hasn't been well studied, so short-term use is what we know most about.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PMA Positive Mental Attitude is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PMA Positive Mental Attitude label
Sources

Sources & How We Checked

PMA Positive Mental Attitude's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 27 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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