Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Potassium Gluconate 550 mg Supplement Ingredients & Drug Interactions

by Nature Made

Potassium Gluconate 550 mg Supplement label
See full label image
Tablet Or Pill Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Potassium Gluconate 550 mg Supplement against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Potassium Gluconate 550 mg Supplement is a dietary supplement by Nature Made with 1 active ingredient. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 62 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Potassium Gluconate 550 mg Supplement by Nature Made

Ask about any prescription or over-the-counter medication and we check it for interactions with Potassium Gluconate 550 mg Supplement by Nature Made — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Potassium Gluconate 550 mg Supplement by Nature Made

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: potassium. It delivers 550 mg of potassium per tablet in the form of potassium gluconate.

The tablet also includes several inactive ingredients—cellulose gel, stearic acid, magnesium stearate, silicon dioxide, and croscarmellose sodium—which are standard binders and flow agents used to hold the tablet together and help it dissolve.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: helps control heart muscle activity.
  • We looked for evidence on: Cardiac function, Arrhythmia, Heart health.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The product facts we hold don't include effectiveness ratings for potassium gluconate as a supplement. If you're considering this for a specific health reason, talk with your doctor or pharmacist about whether the evidence supports it for your situation and whether supplementation is right for you.

The evidence, ingredient by ingredient Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from food is generally safe, but supplements can cause dangerously high blood levels in some people—especially those with kidney disease or taking certain medications. Most people who take it by mouth tolerate it well, though a small number of people report abdominal pain, belching, diarrhea, nausea, and vomiting.

In rare cases, high potassium levels can cause irregular heartbeat, low blood pressure, heart block, mental confusion, or cardiac arrest. For pregnancy, dietary potassium is fine, but use supplements only under medical guidance.

For breastfeeding, dietary potassium is appropriate, but check with your doctor before using a supplement. The supplement form carries different risks than food sources because it can raise blood levels more quickly.

Side effects, ingredient by ingredient Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Potassium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 62 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start this supplement, double-check with your doctor or pharmacist if you take potassium-sparing diuretics, ACE inhibitors, or angiotensin receptor blockers—all carry a Moderate risk of dangerously high blood potassium. These three drug types together affect dozens of common blood pressure medications.

Do not start this supplement without confirming it's safe with your current medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you don't take blood pressure or heart medications and your kidneys work normally, this supplement is worth discussing with your doctor or pharmacist. But if you're on any blood pressure drug—especially ACE inhibitors, ARBs, or potassium-sparing diuretics—you need to confirm with your own healthcare provider before starting it.

Kidney disease is also a red flag. Talk it over with your doctor or pharmacist to make sure it's safe for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Potassium Gluconate 550 mg Supplement, straight from the product label.

Brand Nature Made
Barcode (UPC) 031604017972
Net contents 500 Premium Tablet(s)
Market status On market
Date entered into DSLD Jun 25, 2012
DSLD ID 9198
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Potassium Gluconate 550 mg Supplement by Nature Made, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
031604017972
IngredientAmount% DV
Potassium90 mg3%

Other ingredients: Cellulose Gel, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Croscarmellose Sodium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

VALUE SIZE

Recommended By Pharmacists

ENTER CODE WELLNESS REWARDS CODE VISIT OUR WEBSITE & EARN FREE VITAMINS www.NatureMade.com

HELPS CONTROL ACTIVITY OF THE HEART MUSCLE Potassium Gluconate helps regulate water balance within the body. It works to control the activity of the heart muscle, nervous system and kidneys.

USP has tested and verified ingredients, potency and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org Valid only for U.S. and Puerto Rico residents. Lot.: Exp.:

Supplement

Seals/Symbols

DIETARY SUPPLEMENT USP VERIFIED(TM)

Formulation

No Artificial Colors - No Artificial Flavors - No Preservatives No Chemical Solvents, Yeast or Gluten

Suggested/Recommended/Usage/Directions

SUGGESTED USE: Take one tablet daily with a meal.

Storage

Keep bottle tightly closed.

Precautions

Store in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

List No. 1797 L31AC Cat. 354 5A009

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Potassium Gluconate 550 mg Supplement by Nature Made label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Potassium Gluconate 550 mg Supplement label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Potassium Gluconate 550 mg Supplement by Nature Made

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Potassium

Interacts with
62 drugs
90 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Other (inactive) ingredients: Cellulose Gel, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Croscarmellose Sodium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Potassium Gluconate 550 mg Supplement by Nature Made Drug Interactions

Want to check YOUR meds against Potassium Gluconate 550 mg Supplement?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
62Drugs
62 Moderate

Ingredients driving the most interactions

Potassium 62

Individual Drug Interactions

The ingredients in Potassium Gluconate 550 mg Supplement interact with 62 drugs. Click any drug to see the details.

1 of the 1 ingredient in Potassium Gluconate 550 mg Supplement interact with drugs. Each result below shows which ingredient is responsible. Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Potassium Gluconate 550 mg Supplement with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Potassium Gluconate 550 mg Supplement, from the product label.

Nature Made

See all Nature Made products
Name
Nature Made Nutritional Products
City
Mission Hills
State
CA
ZipCode
91346-9606
Phone Number
1-800-276-2878
Web Address
www.NatureMade.com
Pharmacist Counseling Corner

Potassium Gluconate 550 mg Supplement by Nature Made: Common Questions

Does Potassium Gluconate 550 mg Supplement by Nature Made interact with any medications?
Yes. Based on its ingredients, Potassium Gluconate 550 mg Supplement has a known interaction with 62 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Potassium Gluconate 550 mg Supplement contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have kidney disease?
No—talk with your doctor first. Potassium supplements can cause dangerously high blood levels in people with kidney disease because damaged kidneys can't clear potassium as well. This is a serious safety concern, so get medical guidance before taking this product.
What are the most common side effects?
The most common side effects from taking it by mouth are abdominal pain, belching, diarrhea, flatulence, nausea, and vomiting. Most people tolerate it well, but if your stomach bothers you, let your doctor or pharmacist know.
Is potassium gluconate the only ingredient?
Yes—it's the only active ingredient. The tablet also contains inactive binders like cellulose gel, stearic acid, and magnesium stearate to hold it together, but potassium gluconate is what you're taking it for.
Can I take this while pregnant or breastfeeding?
Dietary potassium from food is fine during both pregnancy and breastfeeding. But if you want to use a supplement, check with your doctor first. They can tell you whether supplementation is right for you and your baby.
What is potassium for?
Potassium is an electrolyte your body needs for heart rhythm, muscle contraction, and fluid balance. You get it naturally from foods like bananas, potatoes, and leafy greens. Supplements are used when your doctor thinks you need extra, but they carry risks if you take certain medications or have kidney problems.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Potassium Gluconate 550 mg Supplement is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Potassium Gluconate 550 mg Supplement label
Go deeper

The Full Monographs Behind Potassium Gluconate 550 mg Supplement’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

Potassium Gluconate 550 mg Supplement's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team