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Dietary supplement

Pregnenolone 10 mg Ingredients & Drug Interactions

by Pure Encapsulations

Pregnenolone 10 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 10 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 10 mg is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 3beta-Hydroxypregn-5-en-20-one. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pregnenolone 10 mg by Pure Encapsulations

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 10 mg by Pure Encapsulations — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone 10 mg by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone (also called 3beta-hydroxypregn-5-en-20-one), a naturally occurring hormone that your body uses as a starting material to make other steroid hormones like estrogen, progesterone, and testosterone. The inactive ingredients are hypoallergenic plant fiber, cellulose, and water — these are just the capsule and filler materials.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for pregnenolone isn't established in the data we hold. Our records show insufficient reliable evidence to rate it for alcohol use disorder, Alzheimer's disease, autism spectrum disorder, back pain, and bipolar disorder.

If you're thinking about using it for one of these conditions, talk with your doctor about whether the research supports it and whether it's right for you.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, but it is a hormone with limited human safety data, so use it only under guidance from a healthcare professional. Reported side effects include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor.

A few people have reported skin abscesses, rashes with burning sensations (possibly related to sun sensitivity), and changes in mood or appetite, though it's not always certain these were caused by pregnenolone itself. The safety data advises against pregnenolone during pregnancy due to unknown risks.

There isn't enough information to know whether it's safe while breastfeeding, so avoid it during that time as well. Because this is a hormone product, talk with your doctor or pharmacist before taking it if you're pregnant, breastfeeding, or planning to become pregnant.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take estrogens, progestins, progesterone, testosterone, or benzodiazepines (sedative medications). All four interact with pregnenolone at Moderate severity — hormonal drugs may be enhanced, while sedatives may be weakened.

These are interactions we've documented; if you're on any of these medication types, a conversation with your healthcare provider is necessary.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone supplement with limited human safety data — only take it under professional guidance. It can enhance the effects of hormone medications (estrogen, progesterone, testosterone, progestin) and may weaken benzodiazepine sedatives, so it's critical to discuss it with your doctor or pharmacist before starting, especially if you take any hormonal or psychiatric medications.

Avoid it in pregnancy and breastfeeding. Run your full medication list through the checker on this page before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 10 mg, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298002200
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 278246
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 10 mg by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
766298002200
IngredientAmount% DV
3beta-Hydroxypregn-5-en-20-one10 mg--

Other ingredients: hypoallergenic Plant Fiber, Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 1 capsule daily, with a meal.

Precautions

Warning: See side panel.

Keep out of the reach of children.

Use only if safety seal is intact.

Warning: Not for use by individuals under the age of 18 years.

Do not use if pregnant or nursing.

Consult a physician or licensed qualified healthcare professional before using this product if you have, or have a family history of, breast cancer, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.

Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified healthcare professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms. To report any adverse event call 1-800-332-1088.

General Statements

Scan to learn about our hypoallergenic supplements

Contents may not fill bottle in order to accommodate required labeling. Please rely on stated quantity.

Seals/Symbols

GFCO.org Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org

Formulation

Hormone precursor to support mood and memory

Gluten-free, Non-GMO & Hypoallergenic

Gluten-free, Non-GMO & Hypoallergenic

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 10 mg by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 10 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 10 mg by Pure Encapsulations

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

3beta-Hydroxypregn-5-en-20-one

Interacts with
82 drugs
10 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

3beta-Hydroxypregn-5-en-20-one monograph & interactions

Other (inactive) ingredients: Hypoallergenic Plant Fiber, Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 10 mg by Pure Encapsulations Drug Interactions

Want to check YOUR meds against Pregnenolone 10 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

3beta-Hydroxypregn-5-en-20-one 82

Individual Drug Interactions

The ingredients in Pregnenolone 10 mg interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone 10 mg interact with drugs. Each result below shows which ingredient is responsible. 3beta-Hydroxypregn-5-en-20-one

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 10 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

3beta-Hydroxypregn-5-en-20-one5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
3beta-Hydroxypregn-5-en-20-one full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 10 mg, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

Pregnenolone 10 mg by Pure Encapsulations: Common Questions

Does Pregnenolone 10 mg by Pure Encapsulations interact with any medications?
Yes. Based on its ingredients, Pregnenolone 10 mg has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 10 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone and what does it do?
Pregnenolone is a naturally occurring hormone your body makes and uses as a building block to create other steroid hormones like estrogen, progesterone, and testosterone. This supplement provides pregnenolone directly, but because it's a hormone with limited safety data in humans, it should only be used under professional guidance.
Does pregnenolone actually work for anything?
The evidence we have isn't established yet. Our records show insufficient reliable evidence to rate pregnenolone for conditions like Alzheimer's disease, autism, back pain, bipolar disorder, or alcohol use disorder. Talk with your doctor if you're interested in it for a specific health goal.
What side effects might I experience?
Most commonly, acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor. A few people have reported skin abscesses, rashes with burning sensations (possibly related to sun exposure), and mood or appetite changes, though it's not always clear these were caused by pregnenolone itself.
Can I take this while pregnant or breastfeeding?
No — the safety data advises against pregnenolone in pregnancy due to unknown risks. There also isn't enough information to know whether it's safe while breastfeeding, so avoid it during that time. Talk with your doctor if you're pregnant, planning to become pregnant, or breastfeeding.
Why does this interact with so many medications?
Because pregnenolone is a precursor — a raw material your body converts into other hormones — it can theoretically enhance the effects of hormone-based medications like estrogens and progesterone. It may also interfere with how sedative medications (benzodiazepines) work in your brain. That's why it's so important to check your specific prescriptions before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pregnenolone 10 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 10 mg label
Go deeper

The Full Monographs Behind Pregnenolone 10 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 10 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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