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Dietary supplement

Pregnenolone 100 mg Ingredients & Drug Interactions

by Best Naturals

Pregnenolone 100 mg label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 100 mg is a dietary supplement by Best Naturals with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone 100 mg by Best Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 100 mg by Best Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone 100 mg by Best Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone, a compound your body naturally produces and uses as a starting point to make other hormones like estrogen, progesterone, and testosterone. The tablet also holds inactive ingredients — dicalcium phosphate, microcrystalline cellulose, silicon dioxide, stearic acid, and magnesium stearate — which are fillers and binders that help hold the tablet together.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports healthy aging, memory and hormonal balance.
  • We looked for evidence on: Aging, Memory.
  • The closest evidence on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Memory (Natural Medicines).
  • Also on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Aging.

The evidence we hold doesn't establish that pregnenolone works reliably for any condition. Our data lists insufficient reliable evidence for autism spectrum disorder, Alzheimer disease, back pain, bipolar disorder, alcohol use disorder, and others.

That means the research so far hasn't been strong enough to say whether it helps. If you're thinking about it for a specific reason, talk it over with your doctor or pharmacist so they can go over what evidence does exist and what might work better.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, but it does come with caveats. It's a hormone with limited human safety data, so it should only be used under guidance from a healthcare professional.

Common side effects reported in people who took it include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor. A few people have also reported skin rashes, skin abscesses, and changes in mood or appetite, though it's not always clear these were caused by the pregnenolone itself.

Pregnancy and breastfeeding are off-limits: the safety data advises against pregnenolone during pregnancy due to unknown risks, and there isn't enough safety information to use it while breastfeeding. If you're pregnant, planning to become pregnant, or nursing, don't take this supplement without talking to your doctor first.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this if you use estrogens, progestins, progesterone, or testosterone (including birth control, hormone replacement therapy, or testosterone therapy). Also double-check if you take benzodiazepines or other sedative medications, as pregnenolone may reduce their calming effect.

These are Moderate-severity concerns, and your healthcare provider needs to know the full picture.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone precursor with very limited proven benefit for any condition, so it's mainly for people who've discussed it with their doctor and have a specific reason to try it. If you take any hormone-related medications — birth control, hormone replacement therapy, testosterone, or sedatives — you need to check with your own doctor or pharmacist before starting, because pregnenolone may alter how those drugs work.

Keep in mind this is a hormone with sparse safety data, so professional guidance is important.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 100 mg, straight from the product label.

Brand Best Naturals
Barcode (UPC) 817716018324
Net contents 120 Tablet(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 270692
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 100 mg by Best Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
120
UPC/BARCODE
817716018324
IngredientAmount% DV
Pregnenolone100 mg--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Silicon Dioxide, Stearic Acid, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Pregnenolone is the starting point from which all steroid hormones are manufactured in our bodies. Its conversion in the body follows different pathways, depending on individual needs. Its main role is as a progenitor hormone for the biosynthesis of other hormones (such as Progesterone, DHEA, cortisol and other sex hormones).

Formulation

Certain research publications indicate that it may help support the following: Supports healthy aging Supports memory and hormonal balance

Premium formula

3rd party lab tested

No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no corn, no soy, no egg, no lactose, no gluten, no wheat, no yeast, no fish.

Precautions

Caution: For adults only, do not use if you are pregnant or nursing. Consult a physician or licensed qualified health care professional before using this product if you have, or have a family history of breast cancer, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.

Caution: For adults only, do not use if you are pregnant or nursing. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in USA

GMP Good Manufacturing Practice Product

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one (1) tablet daily with a meal or as directed by your qualified healthcare professional.

Storage

Keep in cool, dry place.

General Statements

For additional information call 1-877-659-6004

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 100 mg by Best Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 100 mg by Best Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
100 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Silicon Dioxide, Stearic Acid, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 100 mg by Best Naturals Drug Interactions

Want to check YOUR meds against Pregnenolone 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone 100 mg interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone 100 mg interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 100 mg, from the product label.

Best Naturals

See all Best Naturals products
Name
Best Naturals
Street Address
PO Box 394
City
Kenilworth
State
NJ
ZipCode
07033
Phone Number
1-877-659-6004
Web Address
www.shopbestnaturals.com
Pharmacist Counseling Corner

Pregnenolone 100 mg by Best Naturals: Common Questions

Does Pregnenolone 100 mg by Best Naturals interact with any medications?
Yes. Based on its ingredients, Pregnenolone 100 mg has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone?
Pregnenolone is a hormone your body naturally makes. It's a starting material your body uses to produce other hormones like estrogen, progesterone, and testosterone. This supplement is a concentrated dose of that compound.
Can I take pregnenolone if I'm pregnant or breastfeeding?
No. Safety data advises against it during pregnancy because the risks aren't known, and there isn't enough safety information for breastfeeding either. Talk with your doctor before taking this if you're pregnant, planning to become pregnant, or nursing.
What side effects might I see?
Common ones include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor. Less commonly, people have reported skin rashes, skin abscesses, or changes in mood and appetite. Most people tolerate it well, but these are real possibilities.
Does pregnenolone actually work for anything?
We hold insufficient reliable evidence to say it works for autism, Alzheimer disease, back pain, bipolar disorder, alcohol use disorder, or other conditions listed. The research so far hasn't been strong enough to prove a benefit.
Is this safe to take on my own, or do I need a doctor's approval?
Because it's a hormone with limited safety data, it should only be used under guidance from a healthcare professional. Your doctor or pharmacist can tell you whether it makes sense for your situation and whether it interacts with anything you're taking.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pregnenolone 100 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 100 mg label
Go deeper

The Full Monographs Behind Pregnenolone 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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