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Dietary supplement

Pregnenolone 100 mg Ingredients & Drug Interactions

by Klaire Labs

Pregnenolone 100 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 100 mg is a dietary supplement by Klaire Labs with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone, Micronized. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone 100 mg by Klaire Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 100 mg by Klaire Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone 100 mg by Klaire Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone, a micronized form to aid absorption. Pregnenolone is a naturally occurring steroid hormone precursor in your body — it's the starting point your body uses to make other hormones like estrogen, progesterone, testosterone, and cortisol.

The softgel capsule also holds inactive ingredients (hydroxypropyl methylcellulose, water, and microcrystalline cellulose) that serve as the capsule shell and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for pregnenolone is not established in the data we hold. Studies have looked at it for alcohol use disorder, Alzheimer disease, autism spectrum disorder, back pain, and bipolar disorder, but none of these uses have sufficient reliable evidence to rate how well it works.

If you're considering pregnenolone for a specific condition, talk with your doctor about what the current research actually shows.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, but it's a hormone with limited human safety data — use it only under guidance from a healthcare professional. The most commonly reported side effects include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor.

Skin problems like abscess and rash (possibly related to sun sensitivity) and mood or appetite changes have also been reported, though in some cases it's unclear if pregnenolone was the cause. The safety data advises against pregnenolone during pregnancy due to unknown risks, and there isn't enough information to use it while breastfeeding — talk with your doctor or pharmacist for personalized advice on both.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Klaire Labs Pregnenolone, double-check with your doctor or pharmacist if you take estrogens (including birth control pills or HRT), benzodiazepines (like alprazolam or diazepam), progestins, testosterone, or progesterone. Pregnenolone may strengthen the effects of hormonal medications or weaken anxiety drugs — either way, your prescriber needs to know.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone supplement with limited safety data and no well-established effectiveness for the conditions studied so far. It carries Moderate-severity interaction risks with hormonal medications and anti-anxiety drugs.

If you take birth control, HRT, testosterone therapy, progesterone, or benzodiazepines, clear this supplement with your own doctor or pharmacist before starting — don't begin it on your own.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 100 mg, straight from the product label.

Brand Klaire Labs
Barcode (UPC) 817234010329
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 281207
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 100 mg by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
817234010329
IngredientAmount% DV
Pregnenolone, Micronized100 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Water, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free of the following common allergens: Milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, corn and yeast. Contains no artificial colors, flavors, or preservatives.

Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 capsule daily or as directed by a healthcare professional.

Precautions

Do not use if shrinkwrap is broken or missing.

Caution: Not for use by individuals under the age of 18 years.

Do not use if pregnant, may become pregnant, breastfeeding, or have a history of seizures. This product is not intended for long-term daily use. If you have a medical condition (including a family history of breast, uterine, ovarian, prostate or heart disease) have low HDL cholesterol, or are taking prescription drugs, consult your healthcare professional before using this product.

Keep out of reach of children.

Storage

Store in a cool, dry place (59 degrees F - 85 degrees F) away from direct light.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

SFI

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 100 mg by Klaire Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 100 mg by Klaire Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Pregnenolone, Micronized

Interacts with
82 drugs
100 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone, Micronized monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Water, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 100 mg by Klaire Labs Drug Interactions

Want to check YOUR meds against Pregnenolone 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone, Micronized 82

Individual Drug Interactions

The ingredients in Pregnenolone 100 mg interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone 100 mg interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone, Micronized

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone, Micronized5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone, Micronized full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 100 mg, from the product label.

Klaire Labs

See all Klaire Labs products
Name
SFI USA
City
Reno
State
NV
ZipCode
89521
Web Address
Klaire.com
Pharmacist Counseling Corner

Pregnenolone 100 mg by Klaire Labs: Common Questions

Does Pregnenolone 100 mg by Klaire Labs interact with any medications?
Yes. Based on its ingredients, Pregnenolone 100 mg has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take pregnenolone if I'm on birth control?
Probably not without checking first. Pregnenolone may enhance the effects of estrogens and progestins in your birth control, which could raise hormone levels beyond what's intended. Talk with your doctor or pharmacist before adding it.
What are the most common side effects?
Acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor are the most commonly reported. Skin rash and changes in mood or appetite have also been reported, though it's not always clear pregnenolone caused them.
Is pregnenolone safe during pregnancy or breastfeeding?
No. The safety data advises against it during pregnancy due to unknown risks. There also isn't enough information to recommend it while breastfeeding. Talk with your doctor or pharmacist before use if you're pregnant or nursing.
Does pregnenolone actually work for what people take it for?
The evidence isn't established in our data. Studies have looked at it for Alzheimer disease, autism, back pain, bipolar disorder, and alcohol use disorder, but none have sufficient reliable evidence to say whether it works.
What is pregnenolone and what does it do in my body?
Pregnenolone is a hormone your body naturally makes — it's a precursor that converts into other steroid hormones like estrogen, progesterone, testosterone, and cortisol. This product gives you an extra dose as a supplement.
Will pregnenolone make my anti-anxiety medication work better or worse?
Early research suggests chronic pregnenolone use may reduce the calming effects of benzodiazepines like diazepam, meaning they might not work as well. Your doctor or pharmacist should review this before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pregnenolone 100 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 100 mg label
Go deeper

The Full Monographs Behind Pregnenolone 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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