Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Pregnenolone 25 mg Ingredients & Drug Interactions

by Klaire Labs

Pregnenolone 25 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 25 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 25 mg is a dietary supplement by Klaire Labs with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone, Micronized. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pregnenolone 25 mg by Klaire Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 25 mg by Klaire Labs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Pregnenolone 25 mg by Klaire Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: micronized pregnenolone, a hormone precursor your body naturally produces. At 25 mg per capsule, it's the sole active component.

The capsule itself is made with microcrystalline cellulose, hydroxypropyl methylcellulose, water, and ascorbyl palmitate — standard inactive ingredients that help form and stabilize the capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for pregnenolone's effectiveness isn't established in the data we hold. The product facts list several conditions — alcohol use disorder, Alzheimer's disease, autism spectrum disorder, back pain, and bipolar disorder — but all of them carry a rating of insufficient reliable evidence to rate.

That means the research to date isn't strong enough to say whether it actually works for these uses. Before you consider taking it, talk with your doctor or pharmacist about whether the evidence supports its use for your specific situation.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, but it does come with real cautions. Because it's a hormone with limited human safety data, use it only under guidance from a healthcare professional.

The most common side effects reported are acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, sweating, and tremor. Other less common effects include depressive mood, increased appetite, increased motor activity, and a photosensitivity-type rash that cleared on its own.

The safety data advises against use during pregnancy due to unknown risks, and there isn't enough information to recommend it while breastfeeding — talk with your doctor or pharmacist about what's right for you in either situation.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist if you're on estrogens, progestins, progesterone, testosterone, or benzodiazepines. Pregnenolone may enhance the effects of the first four and may blunt the effects of sedatives — all rated Moderate severity.

Your exact medications matter, so use the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone supplement that may interact with birth control, hormone therapy, testosterone, progesterone, and benzodiazepines — so check your medications first. Its effectiveness for the conditions listed isn't established, and it carries real cautions because it's a hormone with limited human safety data.

Use it only under a healthcare professional's guidance, and steer clear during pregnancy or while breastfeeding unless your doctor says otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 25 mg, straight from the product label.

Brand Klaire Labs
Barcode (UPC) 828054016200
Net contents 100 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 322444
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 25 mg by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
828054016200
IngredientAmount% DV
Pregnenolone, Micronized25 mg--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Water, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, and corn. Contains no artificial colors, flavors, or preservatives.

Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.

Suggested/Recommended/Usage/Directions

Suggested Use: Adults: 1 capsule, 1 to 2 times daily with food or as directed by a healthcare professional.

Formula

This product contains pure pregnenolone that has been derived from wild yam and micronized to a very small particle size to facilitate absorption.

Precautions

Do not use if shrinkwrap is broken or missing.

Caution: Not for use by individuals under the age of 18 years. Keep out of reach of children.

Do not use if pregnant, may become pregnant, breastfeeding, or have a history of seizures. If you have a medical condition (including a family history of breast, uterine, ovarian, prostate or heart disease) have low HDL cholesterol, or are taking prescription drugs, consult your physician before using this product.

This product is not intended for long-term daily use.

Storage

Store in a cool, dry place (59 degrees F - 85 degrees F) away from direct light.

FDA Statement of Identity

Dietary Supplement

General Statements

SFI

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 25 mg by Klaire Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 25 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 25 mg by Klaire Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Pregnenolone, Micronized

Interacts with
82 drugs
25 mg per serving Form: Wild Yam

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone, Micronized monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Water, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 25 mg by Klaire Labs Drug Interactions

Want to check YOUR meds against Pregnenolone 25 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone, Micronized 82

Individual Drug Interactions

The ingredients in Pregnenolone 25 mg interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone 25 mg interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone, Micronized

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 25 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone, Micronized5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone, Micronized full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 25 mg, from the product label.

Klaire Labs

See all Klaire Labs products
Name
SFI USA
City
Reno
State
NV
ZipCode
89521
Web Address
Klaire.com
Pharmacist Counseling Corner

Pregnenolone 25 mg by Klaire Labs: Common Questions

Does Pregnenolone 25 mg by Klaire Labs interact with any medications?
Yes. Based on its ingredients, Pregnenolone 25 mg has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 25 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone and what does it do?
Pregnenolone is a hormone your body naturally makes. It acts as a precursor — meaning your body converts it into other steroid hormones like estrogens, progestins, progesterone, and testosterone. The supplement provides an additional source of this hormone, though the evidence for what it actually does for specific health conditions isn't established yet.
Can I take this if I'm on birth control pills?
Not without checking first. Pregnenolone may enhance the effects of estrogens and progestins in birth control, which could change how well it works or how you feel on it. Talk with your pharmacist or doctor before adding this supplement.
What are the most common side effects?
The most frequently reported side effects are acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, sweating, and tremor. Most people tolerate it okay, but these effects can happen — especially with regular use.
Is this safe to take during pregnancy?
No. The safety data advises against use during pregnancy due to unknown risks. If you're pregnant or planning to be, don't take this without explicit approval from your doctor.
Can I take this while breastfeeding?
There isn't enough safety information to recommend it while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you in that situation — they can weigh what's known and what's best for you and your baby.
Does this supplement actually work?
We don't have evidence to say yes. The conditions listed — alcohol use disorder, Alzheimer's disease, autism, back pain, and bipolar disorder — all have insufficient reliable evidence to rate. Before you spend money on it, ask your doctor whether the research supports its use for what you're hoping to treat.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pregnenolone 25 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 25 mg label
Go deeper

The Full Monographs Behind Pregnenolone 25 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 25 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team