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Dietary supplement

Pregnenolone 25 mg Sublingual Ingredients & Drug Interactions

by Douglas Laboratories

Pregnenolone 25 mg Sublingual label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 25 mg Sublingual against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 25 mg Sublingual is a dietary supplement by Douglas Laboratories with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone 25 mg Sublingual by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 25 mg Sublingual by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone 25 mg Sublingual by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone, a hormone precursor your body naturally produces. Pregnenolone can convert into several steroid hormones, including estrogen, progesterone, and testosterone.

The tablet also contains inactive ingredients—mannitol, cellulose, silica, and vegetable stearate—which are excipients that help form and stabilize the tablet.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for pregnenolone's effectiveness in humans is limited. Our data shows insufficient reliable evidence to rate its use for alcohol use disorder, Alzheimer disease, autism spectrum disorder, back pain, or bipolar disorder.

If you're considering this supplement for any of these conditions, the research foundation isn't yet established, and you'd benefit from talking with your doctor about what's actually proven to help.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, but it is a hormone with limited human safety data—use it only under guidance from a healthcare professional. The most commonly reported side effects are acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, and sweating.

Some people have also reported tremor, depressive mood, or changes in appetite. One person developed a rash with burning on the back and sides of the hands, possibly a sun sensitivity reaction, which cleared on its own.

During pregnancy, hormone supplements carry unknown risks and should be avoided. While breastfeeding, there isn't enough safety information, so it should be avoided then too.

If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your own doctor or pharmacist about any benzodiazepines (anti-anxiety or sleep medications), estrogens (including birth control), progestin, testosterone, or progesterone you're taking. Pregnenolone may reduce how well benzodiazepines work and could theoretically strengthen the effects of the hormone medications, though the actual impact varies—especially with testosterone and progesterone.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone may be worth considering if you're exploring hormone support under professional guidance, but the evidence for specific conditions is thin. The main caution is its potential to change how your body responds to hormone-based medications and benzodiazepines.

Pregnant people and those breastfeeding should avoid it. Before you start, run your complete medication list—especially any hormones or anti-anxiety drugs—past your own doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 25 mg Sublingual, straight from the product label.

Brand Douglas Laboratories
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jan 25, 2012
DSLD ID 5212
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 25 mg Sublingual by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
IngredientAmount% DV
Pregnenolone25 mg--

Other ingredients: Mannitol, Cellulose, Silica, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggeted Usage: As a dietary supplement, adults take 1/2 to 1 tablet daily as directed by your healthcare professional ONLY! (May be taken sublingually by allowing tablet to dissolve in mouth or with water or juice.)

Precautions

KEEP OUT OF REACH OF CHILDREN.

DO NOT USE IF PREGNANT OR NURSING.

Consult a physician or licensed qualified health care professional before using this product if you have or have a family history of breast cancer, uterine cancer, ovarian cancer, prostate cancer, prostate enlargement, heart disease, low HDL cholesterol ("good cholesterol"), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not exceed the recommended serving. Exceeding the recommended serving may cause serious adverse health effects. Possible side effects include changes in liver function, acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

Tamper resistant package, do not use if outer seal is missing.

WARNING: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS.

Storage

For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity)

General

Formula #83088

Formulation

This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.

General Statements

To report any adverse events call 1-800-332-1088.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 25 mg Sublingual by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 25 mg Sublingual label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 25 mg Sublingual by Douglas Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.5 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
25 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Mannitol, Cellulose, Silica, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 25 mg Sublingual by Douglas Laboratories Drug Interactions

Want to check YOUR meds against Pregnenolone 25 mg Sublingual?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone 25 mg Sublingual interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone 25 mg Sublingual interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 25 mg Sublingual with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 25 mg Sublingual, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

Pregnenolone 25 mg Sublingual by Douglas Laboratories: Common Questions

Does Pregnenolone 25 mg Sublingual by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, Pregnenolone 25 mg Sublingual has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 25 mg Sublingual contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take pregnenolone if I'm on birth control?
Birth control contains estrogen and progestin. Pregnenolone may theoretically enhance their effects, and research on progesterone shows mixed results depending on the dose. You need to talk with your doctor or pharmacist before combining them, because the interaction depends on your specific medication and dosage.
Will pregnenolone help with Alzheimer disease?
The evidence isn't established yet. Our data shows insufficient reliable evidence to rate pregnenolone for Alzheimer disease, so we can't say whether it works for this condition. Your doctor can discuss whether it might be worth exploring in your situation.
What are the side effects I might notice?
The most common ones are acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, and sweating. Some people report tremor, mood changes, or changes in appetite. One person developed a rash possibly linked to sun sensitivity. These effects are generally temporary, but let your healthcare provider know if they concern you.
Can I take this if I'm pregnant or breastfeeding?
No. Hormone supplements carry unknown risks during pregnancy and should be avoided. There also isn't enough safety information to use it while breastfeeding. If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist.
Why does pregnenolone interact with so many hormones?
Pregnenolone is a precursor—your body converts it into estrogen, testosterone, progesterone, and progestin. Because it feeds into these pathways, taking it can theoretically amplify the effects of those hormones if you're also taking them as medications.
I take diazepam for anxiety. Is pregnenolone safe with it?
Preliminary research shows chronic pregnenolone use may reduce diazepam's calming effects. This is a Moderate interaction. Before combining them, check with your doctor or pharmacist—they'll know whether pregnenolone is appropriate for you alongside your current medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 25 mg Sublingual label
Go deeper

The Full Monographs Behind Pregnenolone 25 mg Sublingual’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 25 mg Sublingual's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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