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Dietary supplement

Pregnenolone 30 mg Ingredients & Drug Interactions

by The Vitamin Shoppe

Pregnenolone 30 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 30 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 30 mg is a dietary supplement by The Vitamin Shoppe with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone 30 mg by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 30 mg by The Vitamin Shoppe — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone 30 mg by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone, a steroid hormone precursor your body naturally makes in small amounts. It's found in the adrenal glands and brain, and it serves as a starting point from which your body can build other hormones like estrogen, progesterone, testosterone, and others.

The capsule also contains rice flour, gelatin, silicon dioxide, and magnesium stearate as inactive ingredients — these are fillers and binders that hold the supplement together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: hormonal support.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for pregnenolone isn't yet established for any of the conditions in our data. We hold ratings for alcohol use disorder, Alzheimer disease, autism spectrum disorder, back pain, and bipolar disorder — all marked as insufficient reliable evidence to rate.

That means the research so far isn't robust enough to say whether it works for these uses or not. If you're considering it for a specific health concern, chat with your doctor about what the current science actually supports.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, but it is a hormone with limited human safety data, so use it only under guidance from a healthcare professional. The most common side effects reported in trials include acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, sweating, and tremor.

A few cases of skin rash with burning sensation on the back and hands have been reported, possibly related to sun sensitivity — these cleared on their own. Some people have also reported depressive mood, increased appetite, or changes in energy and appetite, though it's unclear in all cases whether pregnenolone caused these or something else did.

Based on the safety data available, hormone supplements should be avoided during pregnancy due to unknown risks. Not enough safety information exists about breastfeeding either, so it's best to avoid use while nursing.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before considering this product.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pregnenolone 30 mg, double-check with your doctor or pharmacist if you take any estrogens (like birth control pills or hormone patches), benzodiazepines (sedatives like Valium or Ativan), progestins, progesterone, or testosterone. All are Moderate severity concerns — pregnenolone could amplify hormones or reduce how well sedatives work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone precursor that interacts with several common medication types, most notably birth control, hormone therapies, and sedatives. Because it's a hormone with limited safety data, it really does need oversight from a healthcare professional — this isn't a casual supplement.

If you take any hormonal medications or benzodiazepines, check with your doctor or pharmacist before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 30 mg, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536019496
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2018
DSLD ID 183830
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 30 mg by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
766536019496
IngredientAmount% DV
Pregnenolone30 mg--

Other ingredients: Rice Flour, Gelatin, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Specialty

Hormonal support

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

FDA Statement of Identity

Dietary Supplement

Formulation

Gluten free Dairy free Soy free Nut free

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place.

Precautions

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Warning: Not for use by individuals under the age of 18 years.

Do not use if you are pregnant or nursing. Consult a physician or licensed qualified health care professional before using this product if you have, or have a family history of prostate cancer, prostate enlargement, heart disease, low “good cholesterol” (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.

Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule daily, preferably with a meal.

General

Item No. VS-1949 1318567 ES 37

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 30 mg by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 30 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 30 mg by The Vitamin Shoppe

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
30 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Rice Flour, Gelatin, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 30 mg by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Pregnenolone 30 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone 30 mg interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone 30 mg interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 30 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 30 mg, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-800-223-1216
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Pregnenolone 30 mg by The Vitamin Shoppe: Common Questions

Does Pregnenolone 30 mg by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Pregnenolone 30 mg has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 30 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone and what's it supposed to do?
Pregnenolone is a steroid hormone your body makes naturally in your adrenal glands and brain. It acts as a building block your body uses to create other hormones like estrogen, progesterone, and testosterone. People take it as a supplement hoping it might support mood, memory, or other functions — but the research evidence for any of these claims isn't strong enough yet to confirm it works.
Can I take this while I'm on birth control?
Not without checking with your doctor first. Pregnenolone might enhance the effects of estrogens in birth control pills and patches (a Moderate severity interaction), so your doctor needs to know you're considering it and weigh whether it's safe for you specifically.
What are the most common side effects?
The most frequently reported side effects are acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, sweating, and tremor. A few people have reported skin rashes that seemed to happen with sun exposure. Most side effects occurred in people taking it regularly, and some cleared on their own.
Is it safe to take during pregnancy or while breastfeeding?
No. Hormone supplements should be avoided during pregnancy because the risks aren't known. There's also not enough safety data for breastfeeding, so it's best to skip it while nursing. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking pregnenolone.
Does pregnenolone actually raise testosterone levels?
Theory says it might — pregnenolone is a precursor hormone your body can convert into testosterone — but early research at doses of 30 to 500 mg daily for up to 8 weeks didn't show a measurable effect on testosterone levels. The answer isn't settled yet.
Will this weaken my sedative medications?
Possibly. Early research shows that chronic pregnenolone use can reduce the calming effects of benzodiazepines like diazepam. If you take a sedative or anti-anxiety medication, your doctor needs to know before you start pregnenolone, since they may need to adjust your dose or monitor you more closely.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 30 mg label
Go deeper

The Full Monographs Behind Pregnenolone 30 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 30 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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