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Dietary supplement

Pregnenolone 50 Ingredients & Drug Interactions

by NutriCology

Pregnenolone 50 label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 50 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 50 is a dietary supplement by NutriCology with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone 50 by NutriCology

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 50 by NutriCology — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone 50 by NutriCology

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pregnenolone 50 contains one active ingredient: pregnenolone, a hormone precursor your body naturally makes in small amounts. It's a building block that can be converted into estrogen, progesterone, testosterone, and other steroid hormones.

The tablet also includes several inactive ingredients—microcrystalline cellulose, vegetable oil, vegetable wax, magnesium stearate, vitamin E, and other excipients that make up the tablet itself.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The data we hold rates pregnenolone's effectiveness as insufficient reliable evidence for the conditions listed—alcohol use disorder, Alzheimer's disease, autism spectrum disorder, back pain, bipolar disorder, and others. That means the research so far hasn't been robust enough to say whether it works for these uses.

If you're considering it for a specific reason, that's worth discussing with your doctor or pharmacist.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, pregnenolone is generally well tolerated, but it is a hormone with limited human safety data, so it should only be used under guidance from a healthcare professional. The most common side effects reported in studies include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor.

A small number of users have also reported skin rashes and abscesses, changes in appetite, and mood shifts, though it's not always clear whether pregnenolone was directly responsible. Pregnancy and breastfeeding safety is a concern: hormone supplements should be avoided during pregnancy due to unknown risks, and there isn't enough safety information to use it while breastfeeding.

Talk with your doctor or pharmacist about whether this product is right for you in these situations.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pregnenolone 50, double-check with your doctor or pharmacist if you use estrogens (including birth control pills or hormone replacement therapy), progestins, progesterone, testosterone supplements, or benzodiazepines (anti-anxiety or sedative medications). All of these carry Moderate-severity interaction risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone 50 is a hormone precursor that interacts with birth control, hormone replacement therapy, anti-anxiety medications, and testosterone supplements. Because it's a hormone with limited human safety data, it's important to use it only under guidance from a healthcare professional.

If you take any prescription medications or other hormone products, check them with your doctor or pharmacist before starting. It's not recommended in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 50, straight from the product label.

Brand NutriCology
Barcode (UPC) 713947548107
Net contents 60 scored tablet(s)
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 235415
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 50 by NutriCology, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
713947548107
IngredientAmount% DV
Pregnenolone50 mg--

Other ingredients: Micosolle, Microcrystalline Cellulose, Vegetable oil, Vegetable Wax, Cab-o-sil, Magnesium Stearate, Vitamin E

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Micronized, plant-sourced pregnenolone formulated in a lipid matrix to bypass the liver, with a particle size of less than 50 microns. Derived from non-irradiated and non-ethylene-oxide-treated wild yam.

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, 1 tablet daily with a meal or as directed by a health care professional.

Precautions

Warning: Not for use by individuals under the age of 18 years.

Do not use if pregnant or nursing. Consult a physician or licensed qualified healthcare professional before using this product if you have, or have a family history of, breast cancer, prostate cancer, prostate enlargement, heart disease, low “good” cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.

Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified healthcare professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

Keep out of reach of children.

Pregnenolone may affect levels of other hormones, such as progesterone, estrogen, testosterone, and/or DHEA. Do not take this product if you have a history of seizures. Do not take this product if you have breast cancer, prostate cancer, or other hormone-sensitive diseases. To report any adverse events call 1-800-332-1088.

Storage

Keep in a cool, dry place, tightly capped.

General Statements

NutriCology Innovative Nutrition

Formulation

Micronized Lipid Matrix Hypoallergenic

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 50 by NutriCology label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 50 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 50 by NutriCology

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
50 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Micosolle, Microcrystalline Cellulose, Vegetable oil, Vegetable Wax, Cab-o-sil, Magnesium Stearate, Vitamin E. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 50 by NutriCology Drug Interactions

Want to check YOUR meds against Pregnenolone 50?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone 50 interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone 50 interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 50 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 50, from the product label.

NutriCology

See all NutriCology products
Name
NutriCology
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800.545.9960
Web Address
www.nutricology.com
Pharmacist Counseling Corner

Pregnenolone 50 by NutriCology: Common Questions

Does Pregnenolone 50 by NutriCology interact with any medications?
Yes. Based on its ingredients, Pregnenolone 50 has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 50 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone, and what is it supposed to do?
Pregnenolone is a hormone your body naturally makes in small amounts. It acts as a building block—your body can convert it into estrogen, progesterone, testosterone, and other steroid hormones. The evidence for what it actually does in supplement form isn't strong enough yet to say it works for any of the conditions it's marketed for.
Can I take pregnenolone with birth control pills?
You'll need to check with your doctor or pharmacist first. Pregnenolone may enhance the effects of estrogens, which are in most birth control pills. That could change how the pill works or affect your side effects.
What side effects should I watch for?
The most commonly reported side effects are acne, agitation, diarrhea, drowsiness, hair loss, and sweating. A small number of people have also reported skin rashes, abscesses, or changes in appetite and mood. If you develop any of these, talk with your healthcare provider.
Is pregnenolone safe to take while pregnant or breastfeeding?
No—hormone supplements should be avoided during pregnancy due to unknown risks, and there isn't enough safety data to use it while breastfeeding. Talk with your doctor about your specific situation.
Can I take pregnenolone if I use anti-anxiety medications like Valium?
You should check with your doctor or pharmacist first. Early research suggests pregnenolone may reduce how well benzodiazepines work, but we don't have solid clinical proof yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 50 label
Go deeper

The Full Monographs Behind Pregnenolone 50’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 50's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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