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Dietary supplement

Pregnenolone 50 mg Ingredients & Drug Interactions

by Eurovital Nutraceuticals

Pregnenolone 50 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 50 mg is a dietary supplement by Eurovital Nutraceuticals with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone 50 mg by Eurovital Nutraceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 50 mg by Eurovital Nutraceuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone 50 mg by Eurovital Nutraceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone 50 mg per capsule. Pregnenolone is a naturally occurring steroid hormone precursor — a building block your body can use to make other hormones like estrogen, progesterone, and testosterone.

The remaining ingredients are inert capsule materials and fillers (HPMC capsule, rice flour, and magnesium stearate).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence supporting pregnenolone for any specific condition is not established in the data we hold. Effectiveness ratings for conditions including Alzheimer disease, autism spectrum disorder, back pain, bipolar disorder, and alcohol use disorder all show insufficient reliable evidence to rate — meaning the research so far is too limited or weak to draw firm conclusions.

You'd want to talk with your doctor about whether the research available elsewhere supports its use for your particular situation.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, but it is a hormone with limited human safety data, so use only under guidance from a healthcare professional. Common side effects reported in users include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor.

A few people have reported skin abscesses, skin rashes with burning sensations on the hands (possibly light-sensitive reactions), depressive feelings, and changes in appetite — though in some cases it's unclear if pregnenolone was responsible. Pregnancy and breastfeeding: Safety data advises against pregnenolone during pregnancy due to unknown risks.

There isn't enough safety information to use it while breastfeeding — talk with your doctor or pharmacist about your specific situation.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pregnenolone 50 mg, double-check with your doctor or pharmacist if you take estrogens, progestins, progesterone, or testosterone — pregnenolone may enhance their effects. Also confirm if you use benzodiazepines (anti-anxiety or sleep medications), as pregnenolone may reduce how well they work.

No interactions are documented for the other ingredients we hold data on.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone supplement with limited human safety data and several documented interactions with hormone therapies and sedative medications. It may be worth considering only under close guidance from your doctor or pharmacist, especially if you take estrogens, progestins, testosterone, progesterone, or benzodiazepines.

Before you start, check your exact medications with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 50 mg, straight from the product label.

Brand Eurovital Nutraceuticals
Barcode (UPC) 871230002511
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 22, 2016
DSLD ID 66091
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 50 mg by Eurovital Nutraceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
871230002511
IngredientAmount% DV
Pregnenolone50 mg--

Other ingredients: HPMC Capsule, Rice Flour, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Made in USA

Formulation

Vegan product

No yeast, corn, milk, egg, soy, artificial colors or flavors, added sugar or preservatives.

Formula

3Beta-hydroxypregn-5-en-20-one

Suggested/Recommended/Usage/Directions

Suggested Daily Intake: Take 1 capsule daily.

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: If you are pregnant, lactating or have any health condition, consult a health care professional before using this product.

Do not use this product if the safety seal on the bottle is broken.

Keep out of reach of children.

Storage

Store in a cool, dry place.

General

K15

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 50 mg by Eurovital Nutraceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 50 mg by Eurovital Nutraceuticals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
50 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: HPMC Capsule, Rice Flour, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 50 mg by Eurovital Nutraceuticals Drug Interactions

Want to check YOUR meds against Pregnenolone 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone 50 mg interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone 50 mg interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 50 mg, from the product label.

Eurovital Nutraceuticals

See all Eurovital Nutraceuticals products
Name
Eurovital
Web Address
www.eurovital.com
Pharmacist Counseling Corner

Pregnenolone 50 mg by Eurovital Nutraceuticals: Common Questions

Does Pregnenolone 50 mg by Eurovital Nutraceuticals interact with any medications?
Yes. Based on its ingredients, Pregnenolone 50 mg has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 50 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone and what is it supposed to do?
Pregnenolone is a steroid hormone your body naturally makes. It acts as a building block for other hormones like estrogen, progesterone, and testosterone. It's studied for various conditions, but we don't have strong evidence it works for any of them yet.
What are the most common side effects?
The most frequently reported side effects are acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor. Most people tolerate it fairly well, but these effects do occur in some users.
Can I take this if I'm pregnant or breastfeeding?
No — pregnenolone should be avoided during pregnancy because the risks aren't known. It should also be avoided while breastfeeding due to insufficient safety information. Talk with your doctor or pharmacist if you're planning pregnancy or are nursing.
Why is this called a hormone supplement if it's not a hormone itself?
Pregnenolone is a steroid hormone, but it works by being a precursor — meaning your body converts it into other hormones. That's why it can interact with hormone therapies and why it carries the same caution as a hormone product.
Will this interact with my birth control?
Possibly — if your birth control contains estrogens or progestins, pregnenolone may enhance their effects. Check with your doctor or pharmacist before adding pregnenolone to your routine.
I take a benzodiazepine for anxiety. Is this safe to add?
Early research suggests pregnenolone may reduce how well benzodiazepines work over time, so this combination needs careful oversight. Talk with your doctor before starting pregnenolone.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 50 mg label
Go deeper

The Full Monographs Behind Pregnenolone 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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