Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Pregnenolone 50 mg Ingredients & Drug Interactions

by Superior Source

Pregnenolone 50 mg label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 50 mg is a dietary supplement by Superior Source with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pregnenolone 50 mg by Superior Source

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 50 mg by Superior Source — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Pregnenolone 50 mg by Superior Source

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone at 50 mg per tablet. Pregnenolone is a hormone your body naturally produces; it serves as a starting point from which your body manufactures other steroid hormones, including estrogen, progesterone, testosterone, and others.

The tablet also contains inactive ingredients—lactose and acacia—which are fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on pregnenolone's effectiveness is insufficient to rate it reliably. The data covers uses including alcohol use disorder, Alzheimer disease, autism spectrum disorder, back pain, and bipolar disorder, but the research on each is too limited to draw firm conclusions.

If you're considering pregnenolone for a specific health concern, talk it over with your doctor or pharmacist about what the current evidence actually shows.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, but it is a hormone with limited human safety data—use only under guidance from your healthcare professional. The most common side effects reported in trials include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor.

Some people have also reported skin rashes, depressive mood, and changes in appetite, though it's not always clear if pregnenolone was the cause. During pregnancy, hormone supplements should be avoided due to unknown risks.

There isn't enough safety information to recommend it while breastfeeding either. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take estrogens (including hormonal birth control), benzodiazepines (sedative medications), progestins, testosterone, or progesterone. Pregnenolone may enhance the effects of estrogens, progestins, testosterone, and progesterone, while it may reduce how well benzodiazepines work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a naturally occurring hormone precursor with potential Moderate interactions involving estrogens, benzodiazepines, and hormonal medications like progestins and progesterone. It's generally well tolerated, though acne, mood changes, and other side effects have been reported, and the evidence for most health claims is still too thin to rely on.

Before you start, check your medications—especially any hormonal birth control, hormone therapy, sedatives, or testosterone—with your doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 50 mg, straight from the product label.

Brand Superior Source
Net contents 50 MicroLingual(R) Instant Dissolve Tablet(s)
Market status On market
Date entered into DSLD Feb 24, 2017
DSLD ID 70879
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 50 mg by Superior Source, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 MicroLingual(R) Tablet(s)
Maximum serving Sizes:
1 MicroLingual(R) Tablet(s)
Servings per container
50
IngredientAmount% DV
Pregnenolone50 mg--

Other ingredients: Lactose, Acacia

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Our instant Dissolve MicroLingual tablets may be small but they are full potency! Typical tablets and capsules need to be swallowed and are inefficiently absorbed in the digestive system. MicroLingual tablets dissolve immediately under the tongue heading straight into the body.

General Statements

Our proprietary hydrodrying process results in fewer inactive binders and fillers and a higher ratio of nutritional ingredients - hence the small size. They efficiently provide your body with the nutrients you need right now.

To report any adverse events call 1-800-322-1088

"Less is more" Simplicity Purity Efficiency No pills to swallow

Dissolves on contact

Chewing leads to smooth and better absorption Tablet color, taste and texture may vary slightly form batch to batch. Potency is not affected by these natural variances. Please read all label information

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, dissolve one MIcroLingual tablet under the tongue as directed by your healthcare provider. This product may also be swallowed.

Place on or under the tongue

Seals/Symbols

GMO free

Made in USA

Precautions

California Health & Safety Code Requires The Following Warning: Warning: Not for use by individuals under the age of 18 years.

Do not use if pregnant or nursing. Consult a physician or licensed qualified health care professional before using this product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.

Keep out of reach of children.

Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increase levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

Storage

Keep in cool and dry place.

Formulation

GMO and preservative free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 50 mg by Superior Source label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 50 mg by Superior Source

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 MicroLingual(R) Tablet(s) Dosage formTablet Or Pill Servings per container50 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
50 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Lactose, Acacia. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 50 mg by Superior Source Drug Interactions

Want to check YOUR meds against Pregnenolone 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone 50 mg interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone 50 mg interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 50 mg, from the product label.

Superior Source

See all Superior Source products
Name
Superior Source
City
Los Angeles
State
CA
Phone Number
(800) 421-6175
Web Address
www.superiorsourcevitamins.com
Pharmacist Counseling Corner

Pregnenolone 50 mg by Superior Source: Common Questions

Does Pregnenolone 50 mg by Superior Source interact with any medications?
Yes. Based on its ingredients, Pregnenolone 50 mg has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 50 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take pregnenolone if I'm on birth control?
That depends on what type of birth control you use. If it contains estrogen or progestin, pregnenolone may theoretically enhance their effects, which could change how well your birth control works or alter side effects. Check with your doctor or pharmacist before combining them—don't start without confirming it's safe for your specific situation.
What are the most common side effects?
The most commonly reported side effects are acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor. A few people have also reported skin rashes and mood changes. Most people tolerate it well, but if you notice any of these, talk it over with your healthcare provider.
Is pregnenolone safe during pregnancy or breastfeeding?
No. Hormone supplements should be avoided during pregnancy because the risks aren't known, and there isn't enough safety information to recommend it while breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking this product.
Does pregnenolone actually work for the conditions on the label?
The evidence we have is too limited to say it reliably works for any of them—whether that's Alzheimer disease, back pain, autism, or others. If you're considering it for a specific reason, your doctor or pharmacist can walk you through what research actually exists.
Why does pregnenolone interact with so many hormonal medications?
Because pregnenolone is a precursor—your body uses it as a raw material to build estrogen, progesterone, testosterone, and other steroid hormones. When you add pregnenolone, you're potentially boosting the raw supply your body has available, which can enhance the effects of those same hormones when you're also taking them as medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pregnenolone 50 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 50 mg label
Go deeper

The Full Monographs Behind Pregnenolone 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team