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Dietary supplement

Pregnenolone Ingredients & Drug Interactions

by Ortho Molecular Products

Pregnenolone label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone is a dietary supplement by Ortho Molecular Products with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone by Ortho Molecular Products

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone by Ortho Molecular Products — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone by Ortho Molecular Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone, a hormone precursor your body naturally makes in small amounts. It serves as a starting point for the synthesis of several other steroid hormones, including estrogens, progestins, progesterone, and testosterone.

The tablet also contains several inactive ingredients — isomalt, cane sugar, citric acid, croscarmellose sodium, potassium bicarbonate, natural cherry flavor, sodium stearyl fumarate, stearic acid, silicon dioxide, and cranberry powder — which help form and flavor the tablet but don't contribute to its active effect.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Memory and cognitive support, stress and mood.
  • We looked for evidence on: Memory, Stress, Depression, Aging, Fatigue, Cognitive function — and 1 related terms.
  • The closest evidence on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Depression (Natural Medicines).
  • Also on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Fatigue, Memory, Stress, Aging.

The evidence for pregnenolone's effectiveness is not established in the data we hold. Our information rates its use for alcohol use disorder, Alzheimer disease, autism spectrum disorder, back pain, and bipolar disorder as having insufficient reliable evidence to make a rating.

If you're considering pregnenolone for any of these or other conditions, talk with your doctor about what the research actually supports and whether it's the right choice for you.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, but it is a hormone with limited human safety data, so use only under guidance from a healthcare professional. Common side effects reported in trials include acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, sweating, and tremor.

Less common reports include skin rash (possibly from sun sensitivity, though it cleared on its own), depressive mood, and increased appetite; agitation and increased motor activity have also been reported, though it's unclear if pregnenolone was responsible. Pregnancy and breastfeeding: The safety data advises against use during pregnancy due to unknown risks.

There is not enough safety information for breastfeeding, so avoid it while nursing. Because this is a hormone, talk with your doctor or pharmacist before taking it if you are pregnant, planning pregnancy, or breastfeeding.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking pregnenolone, double-check with your doctor or pharmacist if you take benzodiazepines (anti-anxiety or sedating drugs like diazepam) — pregnenolone may reduce how well they work. You should also verify any estrogens, progestins, progesterone, or testosterone medications or supplements, as pregnenolone may theoretically enhance their effects.

These are Moderate-severity interactions and need a conversation with your own healthcare provider before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone precursor with limited human safety data and no established evidence for most claimed uses. It carries documented risks with hormonal medications (birth control, hormone replacement, testosterone) and may reduce the sedative effects of anti-anxiety drugs.

If you're taking any hormonal or nervous-system medications, or if you're pregnant or nursing, check with your doctor or pharmacist before starting this supplement.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone, straight from the product label.

Brand Ortho Molecular Products
Barcode (UPC) 615033005917
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Jun 25, 2018
DSLD ID 174700
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone by Ortho Molecular Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
100
UPC/BARCODE
615033005917
IngredientAmount% DV
Pregnenolone10 mg--

Other ingredients: Isomalt, Cane Sugar, Natural, Citric Acid, Croscarmellose Sodium, Potassium Bicarbonate, natural Cherry flavor, Sodium Stearyl Fumarate, Stearic Acid, Silicon Dioxide, Cranberry powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: 1 or more tablets per day or as recommended by your health care professional.

Formulation

Formulated To Be Free Of Allergens Derived From: Gluten, yeast, artificial colors and flavors.

Precautions

Do not consume this product if you are pregnant or nursing. Consult your physician for further information.

As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have negative reactions upon ingestion.

Caution: This product contains a desiccant. For best results, keep the desiccant in the bottle until all contents are consumed. Do not eat desiccant.

Keep out of reach of children.

This product was sealed for your protection. Do not use if outer logoed neck seal or inner-seal is missing or damaged.

Do not accept if label shows signs of tampering

Storage

For best results, keep the desiccant in the bottle until all contents are consumed.

Keep container tightly closed. Store at room temperature.

General

Product #591100 Label ID L-OMP100-591100-L V4

General Statements

Learn more

Micronized

Endocrine health

Professional Strength: Not for sale through Amazon.com

Brand IP Statement(s)

VitaSecure

Because efficacy matters

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone by Ortho Molecular Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone by Ortho Molecular Products

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
10 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Isomalt, Cane Sugar, Natural, Citric Acid, Croscarmellose Sodium, Potassium Bicarbonate, Natural Cherry flavor, Sodium Stearyl Fumarate, Stearic Acid, Silicon Dioxide, Cranberry powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone by Ortho Molecular Products Drug Interactions

Want to check YOUR meds against Pregnenolone?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone, from the product label.

Ortho Molecular Products

See all Ortho Molecular Products products
Name
Ortho Molecular Products, Inc.
Street Address
1991 Duncan Place
City
Woodstock
State
IL
ZipCode
60098
Web Address
OrthoMolecularProducts.com
Pharmacist Counseling Corner

Pregnenolone by Ortho Molecular Products: Common Questions

Does Pregnenolone by Ortho Molecular Products interact with any medications?
Yes. Based on its ingredients, Pregnenolone has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone and what does it do in the body?
Pregnenolone is a hormone your body naturally produces. It acts as a precursor — a building block — that your body converts into other hormones like estrogens, progestins, progesterone, and testosterone. This supplement provides pregnenolone in tablet form, but evidence for its effectiveness in treating specific conditions is not established in our data.
Can I take pregnenolone if I'm on birth control or hormone replacement therapy?
Because pregnenolone can theoretically enhance the effects of estrogens and progestins — both common in birth control and hormone replacement — this is a significant interaction you need to discuss with your doctor or pharmacist before starting. They can assess whether it's safe for your situation and adjust your doses if needed.
What are the most common side effects?
Acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, sweating, and tremor have been reported with pregnenolone use. Skin rash with a burning sensation (possibly from sun sensitivity) has also occurred, though it cleared on its own. If you experience any of these, talk with your healthcare provider.
Is pregnenolone safe to use during pregnancy or breastfeeding?
No — the safety data advises against use during pregnancy because the risks are unknown. There is also not enough safety information for breastfeeding, so avoid it while nursing. If you are pregnant, planning pregnancy, or breastfeeding, talk with your doctor before considering this product.
Can pregnenolone interact with my anti-anxiety medication?
Yes. Early research shows that chronic pregnenolone use may reduce the sedative (calming) effects of benzodiazepines like diazepam. If you take any anti-anxiety or sleep medication, check with your doctor or pharmacist before starting pregnenolone.
Does pregnenolone actually raise testosterone levels?
That's unclear. While pregnenolone is a precursor for testosterone, some early research found that taking 30–500 mg daily for up to 8 weeks did not change testosterone levels in people. However, we can't rule out effects at different doses or longer use. Talk with your doctor if testosterone is your goal.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone label
Go deeper

The Full Monographs Behind Pregnenolone’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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