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Dietary supplement

Pregnenolone Cherry Flavored 25 mg Ingredients & Drug Interactions

by Source Naturals

Pregnenolone Cherry Flavored 25 mg label
See full label image
Lozenge Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone Cherry Flavored 25 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone Cherry Flavored 25 mg is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone Cherry Flavored 25 mg by Source Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone Cherry Flavored 25 mg by Source Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone Cherry Flavored 25 mg by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: pregnenolone, a hormone precursor your body naturally produces. It's a lozenge formulation that dissolves in your mouth, flavored with cherry.

The inactive ingredients are mannitol, sorbitol, hydroxypropyl methylcellulose, natural cherry flavor, cellulose gum, silica, stearic acid, and magnesium stearate — these are the binders, sweeteners, and other materials that give the lozenge its form and taste.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence supporting pregnenolone for any specific condition is insufficient to rate. The data we hold shows it's been studied for alcohol use disorder, Alzheimer's disease, autism spectrum disorder, back pain, and bipolar disorder, but in each case the reliable evidence is too limited to say whether it works.

If you're considering it for one of these conditions or another use, talk with your doctor about what the current evidence actually shows and whether it makes sense for you.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth. However, it is a hormone with limited human safety data, so use only under guidance from a healthcare professional.

The most commonly reported side effects include acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, and sweating. A few cases have also reported tremor, depressive mood, increased appetite, or skin rash with a burning sensation (possibly related to sun sensitivity); the rash cleared on its own.

Do not use this product during pregnancy due to unknown risks, and avoid it while breastfeeding — there isn't enough safety information.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before combining pregnenolone with estrogens, progestins, testosterone replacement, progesterone, or benzodiazepines (anti-anxiety medications like diazepam) — all have documented interactions rated Moderate severity. Estrogens, progestins, testosterone, and progesterone may be enhanced; benzodiazepines may become less effective.

Your doctor or pharmacist can weigh whether the benefit outweighs the risk for your situation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone supplement that may interact with estrogens, progestins, testosterone, progesterone, and benzodiazepines. It's generally well tolerated but can cause acne, agitation, and hair loss in some people, and comes with limited safety data.

If you take any hormone medications or anti-anxiety drugs, or if you're pregnant or breastfeeding, talk with your doctor or pharmacist before using it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone Cherry Flavored 25 mg, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078007531
Net contents 120 Lozenge(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 296154
Product type Non-nutrient/non-botanical
Supplement form Lozenge
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone Cherry Flavored 25 mg by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 Lozenge(s)
Maximum serving Sizes:
1 Lozenge(s)
Servings per container
120
UPC/BARCODE
021078007531
IngredientAmount% DV
Pregnenolone25 mg--

Other ingredients: Mannitol, Sorbitol, Hydroxypropyl Methylcellulose, natural Cherry flavor, Cellulose Gum, Silica, Stearic Acid, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Not for use by individuals under the age of 18 years.

Do not use if pregnant, may become pregnant, or breastfeeding. Consult a physician or licensed qualified healthcare professional before using this product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.

Do not exceed recommended serving. Exceeding recommended serving size may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

Have your blood hormone (estrogen, testosterone, DHEA) levels regularly assessed by your physician. Using pregnenolone may elevate your DHEA levels, and DHEA can increase estrogen and testosterone levels. Read entire label before using. Do not use if tamper-evident seal is broken or missing.

Keep out of the reach of children.

Suggested/Recommended/Usage/Directions

Directions: 1 lozenge 1 to 2 times daily. Start with one lozenge per day (one-half lozenge may be sufficient for some persons) and gradually increase to 2 lozenges over several days, as desired. Do not exceed 50 mg daily. Do not take more than 30 days.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Copyright Source Naturals, INC.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone Cherry Flavored 25 mg by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone Cherry Flavored 25 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone Cherry Flavored 25 mg by Source Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.5 Lozenge(s) Dosage formLozenge Servings per container120 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
25 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Mannitol, Sorbitol, Hydroxypropyl Methylcellulose, Natural Cherry flavor, Cellulose Gum, Silica, Stearic Acid, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone Cherry Flavored 25 mg by Source Naturals Drug Interactions

Want to check YOUR meds against Pregnenolone Cherry Flavored 25 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone Cherry Flavored 25 mg interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone Cherry Flavored 25 mg interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone Cherry Flavored 25 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone Cherry Flavored 25 mg, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

Pregnenolone Cherry Flavored 25 mg by Source Naturals: Common Questions

Does Pregnenolone Cherry Flavored 25 mg by Source Naturals interact with any medications?
Yes. Based on its ingredients, Pregnenolone Cherry Flavored 25 mg has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone Cherry Flavored 25 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take pregnenolone if I'm pregnant or breastfeeding?
No. The safety data advises against use during pregnancy due to unknown risks. Avoid it while breastfeeding as well — there isn't enough safety information. If you're considering it and you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist first.
What side effects might I experience?
The most common ones reported are acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, and sweating. A few people have also reported tremor, mood changes, changes in appetite, or a rash (possibly related to sun sensitivity). Most side effects have been mild and have cleared on their own.
Does pregnenolone actually work for Alzheimer's disease or bipolar disorder?
The evidence in our data is insufficient to rate it for those conditions, or for back pain, autism, or alcohol use disorder. There simply isn't enough reliable research to say whether it works. Your doctor can tell you more about what current studies show for your specific situation.
Why is this a hormone supplement and not a vitamin?
Pregnenolone is a steroid hormone your body naturally produces — not a vitamin or mineral. Because it's a hormone with limited human safety data, it should only be used under guidance from a healthcare professional. That's why it's important to check with your doctor or pharmacist before starting.
Can pregnenolone raise my testosterone levels?
Theory suggests pregnenolone might enhance testosterone effects because your body can convert it into testosterone. However, clinical research at doses of 30–500 mg daily for up to 8 weeks showed no actual change in testosterone levels. The effect may depend on your individual body chemistry and dosage.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pregnenolone Cherry Flavored 25 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone Cherry Flavored 25 mg label
Go deeper

The Full Monographs Behind Pregnenolone Cherry Flavored 25 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone Cherry Flavored 25 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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