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Dietary supplement

Pregnenolone Micronized Ingredients & Drug Interactions

by NHC Natural Healthy Concepts

Pregnenolone Micronized label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone Micronized against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone Micronized is a dietary supplement by NHC Natural Healthy Concepts with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone Micronized by NHC Natural Healthy Concepts

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone Micronized by NHC Natural Healthy Concepts — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone Micronized by NHC Natural Healthy Concepts

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone, a hormone precursor found naturally in the body. Pregnenolone sits at the top of the pathway that produces other steroid hormones, including DHEA, progesterone, testosterone, estrogen, and cortisol.

The tablet also contains several inactive ingredients—isomalt, cane sugar, citric acid, croscarmellose sodium, potassium bicarbonate, cherry flavor, sodium stearyl fumarate, stearic acid, and silicon dioxide—which serve as sweeteners, binders, and tablet aids.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for pregnenolone's effectiveness is insufficient to rate for the conditions listed here—alcohol use disorder, Alzheimer's disease, autism spectrum disorder, back pain, and bipolar disorder. That means the data we hold doesn't establish that it works for these uses.

If you're considering it for one of these reasons, talk it over with your doctor or pharmacist about what the current evidence actually supports.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated by mouth, but it is a hormone with limited human safety data, so it should be used only under guidance from a healthcare professional. The most commonly reported side effects include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor.

A small number of users have reported skin rashes with a burning sensation, possibly a light-sensitivity reaction, though the rash cleared on its own. Depressive mood, increased appetite, increased agitation, and changes in motor activity have also been reported, though it isn't certain these were caused by pregnenolone itself.

Hormone supplements should be avoided during pregnancy due to unknown risks. There isn't enough safety data to use this product while breastfeeding, so talk with your doctor or pharmacist about whether it's right for you in that situation.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take estrogens, progestins, testosterone, progesterone, or any hormone-based medication—pregnenolone may enhance their effects. Also verify if you take benzodiazepines (anti-anxiety or sleep medications), as pregnenolone may reduce how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone may be worth considering if you and your healthcare provider think it fits your needs—but because it's a hormone with limited safety data and real interactions with hormone-based medications and anti-anxiety drugs, it's not a take-on-your-own decision. Check your exact medications with your doctor or pharmacist before you start, especially if you take birth control, hormone replacement, testosterone therapy, or benzodiazepines.

Avoid it in pregnancy and while breastfeeding unless your doctor advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone Micronized, straight from the product label.

Brand NHC Natural Healthy Concepts
Barcode (UPC) 647732925111
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Nov 19, 2021
DSLD ID 256205
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone Micronized by NHC Natural Healthy Concepts, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
100
UPC/BARCODE
647732925111
IngredientAmount% DV
Pregnenolone10 mg--

Other ingredients: Isomalt, Cane Sugar, Natural, Citric Acid, Croscarmellose Sodium, Potassium Bicarbonate, natural Cherry flavor, Sodium Stearyl Fumarate, Stearic Acid, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: 1 or more tablets per day or as recommended by your health care professional.

Formulation

Formulated to be free of allergens derived from: gluten, corn, yeast, artificial colors and flavors.

Precautions

Do not consume this product if you are pregnant or nursing.

Consult your physician for further information.

As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredients panel carefully prior to ingestion. Cease taking this product and consult physician if you have negative reactions upon ingestion.

Caution: This product contains a desiccant. For best results, keep the desiccant in the bottle until all contents are consumed. Do not eat desiccant.

Keep out of reach of children.

Keep out of reach of children.

This product was sealed for your protection. Do not use if outer logoed neck seal or inner-seal is missing or damaged.

Storage

Keep container tightly closed. Store at room temperature.

FDA Statement of Identity

Dietary Supplement

General Statements

Professional use only

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone Micronized by NHC Natural Healthy Concepts label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone Micronized label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone Micronized by NHC Natural Healthy Concepts

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
10 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Isomalt, Cane Sugar, Natural, Citric Acid, Croscarmellose Sodium, Potassium Bicarbonate, Natural Cherry flavor, Sodium Stearyl Fumarate, Stearic Acid, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone Micronized by NHC Natural Healthy Concepts Drug Interactions

Want to check YOUR meds against Pregnenolone Micronized?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone Micronized interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone Micronized interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone Micronized with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone Micronized, from the product label.

NHC Natural Healthy Concepts

See all NHC Natural Healthy Concepts products
Name
NHC
Street Address
310 N Westhill Blvd.
City
Appleton
State
WI
ZipCode
54914
Pharmacist Counseling Corner

Pregnenolone Micronized by NHC Natural Healthy Concepts: Common Questions

Does Pregnenolone Micronized by NHC Natural Healthy Concepts interact with any medications?
Yes. Based on its ingredients, Pregnenolone Micronized has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone Micronized contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone and what does it do?
Pregnenolone is a hormone your body makes naturally. It's a precursor—a building block—for other steroid hormones, including progesterone, testosterone, estrogen, DHEA, and cortisol. The body converts pregnenolone into these other hormones as needed.
Can I take this if I'm pregnant or breastfeeding?
No. Hormone supplements should be avoided during pregnancy due to unknown risks. There also isn't enough safety information to use this product while breastfeeding. Talk with your doctor or pharmacist about what's right for your situation.
What side effects does pregnenolone cause?
Pregnenolone is generally well tolerated by mouth, but common side effects include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor. A small number of users have reported skin rashes, possibly related to light sensitivity. Mood changes, appetite changes, and increased agitation have also been reported, though it's unclear if pregnenolone was the cause.
Does it work for Alzheimer's disease, back pain, or bipolar disorder?
The evidence isn't established in the data we hold for any of those uses—Alzheimer's disease, back pain, bipolar disorder, autism spectrum disorder, and alcohol use disorder all have insufficient reliable evidence to rate. Talk with your doctor about what research actually supports for your specific condition.
Will this interact with my birth control or hormone replacement?
Possibly. Pregnenolone is a precursor to estrogens and progestins, so it may enhance the effects of those medications. Check your exact medications with your doctor or pharmacist before you start this product.
Will this interact with my anti-anxiety or sleep medication?
It may. Early research suggests pregnenolone can reduce the sedative effects of benzodiazepines (like diazepam). Verify with your doctor or pharmacist if you take any anti-anxiety or sleep medications before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pregnenolone Micronized is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone Micronized label
Go deeper

The Full Monographs Behind Pregnenolone Micronized’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone Micronized's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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