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Dietary supplement

Pregnenolone Powder 20 mg Ingredients & Drug Interactions

by BulkSupplements.com

Pregnenolone Powder 20 mg label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone Powder 20 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone Powder 20 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone Powder 20 mg by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone Powder 20 mg by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone Powder 20 mg by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone at 20 mg per serving. Pregnenolone is a steroid hormone precursor — your body can convert it into several other hormones, including estrogens, progesterone, testosterone, and DHEA.

There are no inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for pregnenolone isn't established in the data we hold. We have insufficient reliable evidence to rate it for alcohol use disorder, Alzheimer disease, autism spectrum disorder, back pain, or bipolar disorder.

If you're considering it for a specific condition, talk with your pharmacist about what the current research actually shows.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, though it's a hormone with limited human safety data, so use it only under guidance from a healthcare professional. The most common side effects reported in trials include acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, sweating, and tremor.

A few cases of skin rash with burning sensation on the hands have also been reported, possibly tied to light sensitivity; those rashes cleared on their own. Some people have also reported depressive mood or increased appetite, though it's unclear whether pregnenolone caused these.

Pregnancy safety advises against hormone supplements due to unknown risks. There isn't enough safety information to use it while breastfeeding — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking pregnenolone, double-check with your pharmacist or doctor if you take estrogens (including birth control pills), progestins, progesterone, testosterone, or benzodiazepines. All four types may be affected.

No interactions are documented for other drug classes in the data we hold, but your exact medications need to be verified with the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone precursor with moderate interactions involving several medication types, especially hormonal birth control, progesterone, testosterone, and benzodiazepines. It's generally well tolerated but comes with limited human safety data, so it's not a casual supplement — work with your healthcare provider.

Check your exact medications before you start, and mention this product to your pharmacist if you're on any hormone therapy or sedative.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone Powder 20 mg, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X003B8GP3P
Net contents 500 Gram(s); 17.6 Ounce(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 330357
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone Powder 20 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
20 mg
Maximum serving Sizes:
50 mg
Servings per container
25000
UPC/BARCODE
X003B8GP3P
IngredientAmount% DV
Pregnenolone20 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Pregnenolone Powder 20 mg per serving

Brand IP Statement(s)

BulkSupplements.com Clean & Pure Bulk Supplements

Storage

Store in a dry, cool place Contents are sold by weight, not volume. Settling may occur.

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Do not exceed 50 mg per day. Do not take for more than 30 days without the approval of a healthcare professional.

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 20 mg once or twice daily, or as directed by a physician.

General Statements

Use an accurate milligram scale. New

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone Powder 20 mg by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone Powder 20 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone Powder 20 mg by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size20 mg Dosage formPowder Servings per container25000 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
20 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions
Interaction report

Pregnenolone Powder 20 mg by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Pregnenolone Powder 20 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone Powder 20 mg interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone Powder 20 mg interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone Powder 20 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone Powder 20 mg, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Pregnenolone Powder 20 mg by BulkSupplements.com: Common Questions

Does Pregnenolone Powder 20 mg by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Pregnenolone Powder 20 mg has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone Powder 20 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is pregnenolone, and what does it do?
Pregnenolone is a steroid hormone that your body can convert into other hormones like estrogen, progesterone, testosterone, and DHEA. It's a precursor — a building block — rather than one of those hormones itself. We don't have strong evidence that it works for any specific condition yet.
Can I take this if I'm on birth control?
Not without checking first. Pregnenolone may enhance the effects of estrogens and progestins in birth control, so the risk and benefit need to be discussed with your prescriber. Don't start it on your own.
What side effects should I watch for?
The most common ones reported are acne, agitation, drowsiness, diarrhea, tremor, sweating, hair loss, and skin abscess. A few people have had skin rashes with burning on the hands, possibly from light sensitivity. Most went away on their own. If you notice mood changes or strange skin reactions, stop and call your pharmacist or doctor.
Is it safe during pregnancy or breastfeeding?
No — the safety data advises against hormone supplements in pregnancy due to unknown risks. There also isn't enough information to use it while breastfeeding. Talk with your doctor or pharmacist about your individual situation if pregnancy or breastfeeding applies to you.
I take a benzodiazepine for anxiety. Can I use pregnenolone too?
This is a moderate interaction you need to discuss with your prescriber first. Pregnenolone may reduce how well your benzodiazepine works, so your doctor needs to know if you're considering it. Do not add it without talking to them.
Does pregnenolone actually raise testosterone levels?
It's unclear. While pregnenolone might theoretically enhance testosterone effects, early research at doses up to 500 mg daily for eight weeks did not actually show an increase in testosterone levels in people. The theory and the real-world result don't match — yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone Powder 20 mg label
Go deeper

The Full Monographs Behind Pregnenolone Powder 20 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone Powder 20 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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