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Dietary supplement

Premier Pregnenolone Ingredients & Drug Interactions

by Premier Research Labs

Premier Pregnenolone label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Premier Pregnenolone against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Premier Pregnenolone is a dietary supplement by Premier Research Labs with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Premier Pregnenolone by Premier Research Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Premier Pregnenolone by Premier Research Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Premier Pregnenolone by Premier Research Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone, a hormone precursor your body naturally produces. Pregnenolone sits at the top of your steroid hormone pathway — your body can convert it into estrogen, progesterone, testosterone, and other hormones depending on what it needs.

The capsule also contains three inactive ingredients: brown rice protein, cellulose (a plant fiber used as a binder), and water.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Hormone support and precursor function.
  • We looked for evidence on: Aging, Fatigue, Memory, Stress, Adrenal support, Hormonal balance.
  • The closest evidence on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Fatigue (Natural Medicines).
  • Also on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Memory, Stress, Aging.

The data we hold on pregnenolone shows insufficient reliable evidence to rate it for any condition — including alcohol use disorder, Alzheimer disease, autism spectrum disorder, back pain, and bipolar disorder. That doesn't mean it doesn't work; it means the research isn't there yet to say one way or the other.

If you're considering it for a specific reason, talk it over with your doctor or pharmacist about what evidence exists outside our data.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth. The most common side effects reported in studies are acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin abscess, sweating, and tremor.

A few people have reported skin rashes with a burning sensation, possibly related to sun sensitivity; one case cleared on its own. Some have also reported changes in mood, appetite, and energy levels, though it's unclear if pregnenolone was the cause.

Because pregnenolone is a hormone with limited human safety data, use it only under the guidance of a healthcare professional. The safety information advises against it during pregnancy due to unknown risks, and there isn't enough data to know if it's safe while breastfeeding — talk with your doctor or pharmacist before using it if you're pregnant, trying to conceive, or nursing.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this supplement, double-check with your doctor or pharmacist if you take estrogens, progestins, testosterone, progesterone, or benzodiazepines. These medications may have their effects enhanced (or in the case of benzodiazepines, potentially reduced) by pregnenolone.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Premier Pregnenolone is a hormone precursor with interactions across multiple medication types, most notably estrogens and anti-anxiety medications. If you're on hormone therapy, birth control, benzodiazepines, or testosterone therapy, you'll want to check with your doctor or pharmacist before starting this.

The evidence for its effectiveness in treating specific conditions isn't established in the data we hold, so clarify your goals with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Premier Pregnenolone, straight from the product label.

Brand Premier Research Labs
Barcode (UPC) 807735025304
Net contents 60 Plant-Source Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 297564
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Premier Pregnenolone by Premier Research Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
807735025304
IngredientAmount% DV
Pregnenolone100 mg--

Other ingredients: Brown Rice Protein, Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule daily or as directed by a health professional.

Formula

Pregnenolone is a precursor to many important hormones. This product features premier quality pregnenolone in a natural base of rice protein.

Precautions

Tamper Seal: Use only if seal is intact. Do not take this product if you have a history of seizures. As with all hormone related products, consult your health professional before taking this or any other product.

Keep out of reach of children.

Warning: Not for use by individuals under the age of 18 years.

Do not use if pregnant or nursing. Consult a physician or licensed qualified health-care professional before using this product if you have, or have a family history of, breast cancer, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.

Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified healthcare professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Premier Hormone Support

PRL's Quality Guarantee Plant-Based Identity by HPLC Heavy Metal Tested FDA-Monitored cGMP Facility

Non-GMO Gluten Free Soy Free Casein Free No added magnesium stearate

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Premier Pregnenolone by Premier Research Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Premier Pregnenolone label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Premier Pregnenolone by Premier Research Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
100 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Brown Rice Protein, Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Premier Pregnenolone by Premier Research Labs Drug Interactions

Want to check YOUR meds against Premier Pregnenolone?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Premier Pregnenolone interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Premier Pregnenolone interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Premier Pregnenolone with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Premier Pregnenolone, from the product label.

Premier Research Labs

See all Premier Research Labs products
Name
Premier Research Labs
Pharmacist Counseling Corner

Premier Pregnenolone by Premier Research Labs: Common Questions

Does Premier Pregnenolone by Premier Research Labs interact with any medications?
Yes. Based on its ingredients, Premier Pregnenolone has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Premier Pregnenolone contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is pregnenolone safe to take if I'm on birth control?
Not without checking first. Birth control pills contain estrogens and progestins, and pregnenolone may enhance their effects since it's a precursor for both hormones. Talk with your doctor or pharmacist before adding this to your routine.
What are the most common side effects?
Acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor have all been reported. A few people have also experienced changes in mood and appetite, though it's not certain pregnenolone was the cause.
Can I take this while pregnant or breastfeeding?
The safety data advises against it during pregnancy due to unknown risks. There's also not enough data to know if it's safe while breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're pregnant, trying to conceive, or nursing.
Does pregnenolone actually boost testosterone levels?
The research is mixed. Pregnenolone is a precursor for testosterone, so theoretically it might enhance testosterone effects, but studies show it doesn't consistently raise testosterone levels — the effect may depend on the dose.
Will this help with my anxiety or sleep?
Early research suggests chronic pregnenolone use might actually reduce the calming and sedative effects of anti-anxiety medications like diazepam. If you're on benzodiazepines, definitely check with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Premier Pregnenolone label
Go deeper

The Full Monographs Behind Premier Pregnenolone’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Premier Pregnenolone's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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