Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

PRO-Kids Tangy Orange Ingredients & Drug Interactions

by Hyperbiotics

PRO-Kids Tangy Orange label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PRO-Kids Tangy Orange against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PRO-Kids Tangy Orange is a dietary supplement by Hyperbiotics with 5 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L. acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against PRO-Kids Tangy Orange by Hyperbiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with PRO-Kids Tangy Orange by Hyperbiotics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of PRO-Kids Tangy Orange by Hyperbiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (57.20 mg) without saying how much of each component you get.

PRO-Kids Tangy Orange is a 5-ingredient kids' probiotic tablet with a proprietary blend of beneficial bacteria (including L. acidophilus, B. longum infantis, L. plantarum, and B. animalis lactis), plus fructooligosaccharides, a prebiotic fiber that feeds the good bacteria. The rest is inactive ingredients—cellulose, pectin, gum, and other binding and flavoring agents—to hold it together and make it taste like tangy orange.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Gut health support for children.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Fructo-oligosaccharides (fos) is rated "Insufficient Reliable Evidence To Rate" for Constipation.

L. acidophilus is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, and helicobacter pylori infection, and possibly effective for bacterial vaginosis. The evidence for fructooligosaccharides is less clear — studies haven't yet established solid proof that it works for constipation, blood sugar control, bone health, or cholesterol.

The other probiotic strains in this product don't have effectiveness ratings in our data.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Fructo-oligosaccharides (fos)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L. acidophilus is generally well tolerated in healthy children, though mild stomach discomfort, bloating, or gas can happen when you first start any probiotic. Fructooligosaccharides can cause bloating, gas, and abdominal pain, especially at higher doses, though studies suggest that lower doses (under 10 grams daily) are generally mild.

Because supplement-level doses of FOS aren't well studied, check with your child's doctor before using this product. For B. longum infantis, L. plantarum, and B. animalis lactis, safety data during pregnancy or breastfeeding isn't on file here.

L. acidophilus is rated possibly safe in pregnancy.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Fructo-oligosaccharides (fos)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check antibiotic drugs with your child's doctor or pharmacist before starting this product. Space antibiotics several hours away from PRO-Kids Tangy Orange so they don't interfere with each other.

No other medication interactions are documented for the ingredients we could check, though we don't have interaction data for several of the probiotic strains in the blend.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This kids' probiotic may help with certain digestive issues if your child is on the right medication schedule. The main thing to watch is timing with antibiotics — space them out so the antibiotic doesn't kill the good bacteria.

Talk with your child's doctor or pharmacist before starting, especially if your child is taking antibiotics or has any health concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PRO-Kids Tangy Orange, straight from the product label.

Brand Hyperbiotics
Barcode (UPC) 9506000058528
Net contents 60 Chewable, Time-Release Micro-Pearl(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 306767
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PRO-Kids Tangy Orange by Hyperbiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Pearl Tablet(s)
Maximum serving Sizes:
1 Pearl Tablet(s)
Servings per container
60
UPC/BARCODE
9506000058528
IngredientAmount% DV
Total Carbohydrates0 Gram(s)1%, 1%
Added Sugars0 Gram(s)1%, 1%
Total Sugars0 Gram(s)--
Proprietary Probiotic Blend57.2 mg--
Fructooligosaccharides25 mg--
L. acidophilus0 NP--
B. longum infantis0 NP--
L. plantarum0 NP--
B. animalis lactis0 NP--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Pectin, Stearic Acid, Sodium Carbonate, natural Orange extract, Stevia, Guar Gum, Turmeric

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

For more information on gut health and to reorder, visit hyperbiotics.com

BIO-Tract vs. instant release formulations under in vitro test conditions. BIO-tract is a registered trademark of Probi USA, Inc.

Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 pearl tablet once per day.

Storage

No refrigeration necessary. Store in a cool, dry place.

Precautions

Keep out of reach of children. Warning: Choking hazard. For children of safe chewing age and older. Adult supervision required.

Use only if safety seal is intact.

Formulation

Free of dairy, gluten, soy, peanut, tree nut, egg, fish, shellfish, active yeast, preservatives, artificial flavors and colors, and added sugar, and is non-GMO.

Gut and immune support

Sugar free Dairy free Gluten free

Vegan

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

3 Billion CFU At manufacture. Minimum of 1 billion CFU at expiration. 4 Strains 15x More Survivability

FDA Statement of Identity

Premium Probiotic Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PRO-Kids Tangy Orange by Hyperbiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PRO-Kids Tangy Orange label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PRO-Kids Tangy Orange by Hyperbiotics

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Pearl Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

57.2 mg per serving
  • › L. acidophilus
  • › B. longum infantis
  • › L. plantarum
  • › B. animalis lactis

Fructooligosaccharides

No known
interactions
25 mg per serving

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are gener...

Fructooligosaccharides monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Pectin, Stearic Acid, Sodium Carbonate, Natural Orange extract, Stevia, Guar Gum, Turmeric. These complete the product’s ingredient list but are not active constituents.

Interaction report

PRO-Kids Tangy Orange by Hyperbiotics Drug Interactions

Want to check YOUR meds against PRO-Kids Tangy Orange?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

L. acidophilus 182

Individual Drug Interactions

The ingredients in PRO-Kids Tangy Orange interact with 182 drugs. Click any drug to see the details.

1 of the 5 ingredients in PRO-Kids Tangy Orange interact with drugs. Each result below shows which ingredient is responsible. L. acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in PRO-Kids Tangy Orange with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L. acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
L. acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PRO-Kids Tangy Orange, from the product label.

Hyperbiotics

See all Hyperbiotics products
Name
Hyperbiotics
Street Address
45 Kenneth Dooley Drive
City
Middletown
State
CT
ZipCode
06457
Web Address
hyperbiotics.com
Pharmacist Counseling Corner

PRO-Kids Tangy Orange by Hyperbiotics: Common Questions

Does PRO-Kids Tangy Orange by Hyperbiotics interact with any medications?
Yes. Based on its ingredients, PRO-Kids Tangy Orange has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PRO-Kids Tangy Orange contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can my child take this while on antibiotics?
Not at the same time. Antibiotics kill the live bacteria in probiotics, so they won't work. Ask your child's doctor or pharmacist how far apart to take them—typically a few hours is recommended.
What's fructooligosaccharides and why is it in here?
It's a fiber that feeds the good bacteria in the probiotic, helping them thrive. It's generally well tolerated, but it can cause bloating and gas, especially when your child first starts taking it.
Will this help my child's digestion?
L. acidophilus may help with certain digestive issues like irritable bowel syndrome or diarrhea, especially if caused by antibiotics. The evidence is strongest for those specific conditions; results vary from child to child.
What side effects might my child have?
Mild stomach discomfort, bloating, gas, or diarrhea can happen when starting any probiotic—these usually settle down. Serious side effects are rare in healthy kids.
Is it safe for my baby during pregnancy or breastfeeding?
L. acidophilus is rated possibly safe in pregnancy. For the other probiotic strains and for breastfeeding safety, we don't have enough data. Talk with your doctor or midwife before using this during pregnancy or while nursing.
Does this product have fillers?
Yes—it contains microcrystalline cellulose, pectin, gum, and other binders to hold the tablet together and give it flavor. Those are standard inactive ingredients in most supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PRO-Kids Tangy Orange is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PRO-Kids Tangy Orange label
Go deeper

The Full Monographs Behind PRO-Kids Tangy Orange’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph →
Sources

Sources & How We Checked

PRO-Kids Tangy Orange's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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